ZOSYN

Adverse Events

Drug Profile

Learn More

Reference

About Results

Comments

Zosyn Adverse Events Reported to the FDA Over Time

How are Zosyn adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Zosyn, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Zosyn is flagged as the suspect drug causing the adverse event.

Most Common Zosyn Adverse Events Reported to the FDA

What are the most common Zosyn adverse events reported to the FDA?

Pyrexia	282 (2.15%)
Renal Failure Acute	261 (1.99%)
Thrombocytopenia	200 (1.52%)
Rash	188 (1.43%)
Drug Rash With Eosinophilia And Sys...	144 (1.1%)
Neutropenia	142 (1.08%)
Alanine Aminotransferase Increased	141 (1.07%)
Toxic Epidermal Necrolysis	133 (1.01%)
Aspartate Aminotransferase Increase...	123 (.94%)
Sepsis	120 (.91%)
Pruritus	110 (.84%)
	Show More
Stevens-johnson Syndrome	110 (.84%)
Condition Aggravated	109 (.83%)
Diarrhoea	109 (.83%)
Pancytopenia	109 (.83%)
Hepatic Function Abnormal	98 (.75%)
Renal Failure	97 (.74%)
Death	96 (.73%)
Pneumonia	96 (.73%)
Drug Interaction	92 (.7%)
Multi-organ Failure	90 (.68%)
Acute Respiratory Distress Syndrome	87 (.66%)
Hypotension	87 (.66%)
Rash Maculo-papular	84 (.64%)
Septic Shock	83 (.63%)
Agranulocytosis	80 (.61%)
Interstitial Lung Disease	79 (.6%)
Rash Erythematous	79 (.6%)
Dyspnoea	77 (.59%)
Eosinophilia	74 (.56%)
Platelet Count Decreased	74 (.56%)
Leukopenia	73 (.56%)
Blood Creatinine Increased	72 (.55%)
Respiratory Failure	72 (.55%)
Liver Disorder	69 (.53%)
White Blood Cell Count Decreased	68 (.52%)
Gamma-glutamyltransferase Increased	67 (.51%)
Blood Alkaline Phosphatase Increase...	65 (.49%)
Cholestasis	65 (.49%)
Renal Impairment	65 (.49%)
Tubulointerstitial Nephritis	64 (.49%)
Drug Hypersensitivity	63 (.48%)
Erythema	63 (.48%)
Disseminated Intravascular Coagulat...	60 (.46%)
Clostridial Infection	59 (.45%)
Paraesthesia	58 (.44%)
Drug Ineffective	57 (.43%)
Blood Bilirubin Increased	56 (.43%)
Hepatic Failure	56 (.43%)
Anaemia	55 (.42%)
Chills	55 (.42%)
Encephalopathy	54 (.41%)
Jaundice	52 (.4%)
Tachycardia	52 (.4%)
Hypoglycaemia	51 (.39%)
Haemorrhage Intracranial	50 (.38%)
Clostridium Difficile Colitis	49 (.37%)
Anaphylactic Reaction	48 (.37%)
Cytolytic Hepatitis	48 (.37%)
Nausea	46 (.35%)
Vomiting	46 (.35%)
Blood Pressure Decreased	45 (.34%)
Oedema Peripheral	45 (.34%)
Urticaria	44 (.33%)
Bone Marrow Failure	42 (.32%)
Convulsion	41 (.31%)
Hypersensitivity	41 (.31%)
Liver Function Test Abnormal	41 (.31%)
Haemoglobin Decreased	40 (.3%)
Rash Generalised	40 (.3%)
Febrile Neutropenia	39 (.3%)
Rash Pruritic	39 (.3%)
Renal Tubular Necrosis	39 (.3%)
Blister	38 (.29%)
Cardio-respiratory Arrest	38 (.29%)
Pain	38 (.29%)
Cardiac Arrest	37 (.28%)
Cardiac Failure	37 (.28%)
Skin Exfoliation	37 (.28%)
Weight Decreased	37 (.28%)
Anaphylactic Shock	36 (.27%)
Drug Eruption	36 (.27%)
Haemolytic Anaemia	36 (.27%)
Lung Disorder	36 (.27%)
Blood Lactate Dehydrogenase Increas...	35 (.27%)
Confusional State	35 (.27%)
Hepatic Enzyme Increased	35 (.27%)
Nephropathy Toxic	35 (.27%)
Dialysis	34 (.26%)
Haemodialysis	34 (.26%)
Decreased Appetite	33 (.25%)
Pleural Effusion	33 (.25%)
Pneumonia Aspiration	33 (.25%)
Renal Disorder	33 (.25%)
Dehydration	32 (.24%)
Dermatitis Exfoliative	32 (.24%)
Hypokalaemia	32 (.24%)
Toxic Skin Eruption	32 (.24%)
Blood Urea Increased	31 (.24%)
International Normalised Ratio Incr...	31 (.24%)
Rhabdomyolysis	31 (.24%)

Share/Embed Graph Export Data

This graph shows the top adverse events submitted to the FDA for Zosyn, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Zosyn is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Zosyn

What are the most common Zosyn adverse events reported to the FDA?

Epidermal And Dermal Conditions	1457 (11.09%)
Hepatic And Hepatobiliary	629 (4.79%)
Infections - Pathogen Unspecified	606 (4.61%)
Renal Disorders	554 (4.22%)
Hepatobiliary	497 (3.78%)
White Blood Cell	458 (3.49%)
Bacterial Infectious	441 (3.36%)
Hematology Investigations	405 (3.08%)
Respiratory	377 (2.87%)
Neurological	321 (2.44%)
Body Temperature Conditions	298 (2.27%)
	Show More
Lower Respiratory Tract Disorders	284 (2.16%)
Anemias Nonhemolytic And Marrow Dep...	242 (1.84%)
Cardiac Arrhythmias	231 (1.76%)
Platelet	231 (1.76%)
Allergic Conditions	224 (1.7%)
Therapeutic And Nontherapeutic Effe...	213 (1.62%)
Gastrointestinal Signs	179 (1.36%)
Renal And Urinary Tract Investigati...	157 (1.19%)
Gastrointestinal Motility And Defec...	151 (1.15%)
Nephropathies	144 (1.1%)
Decreased And Nonspecific Blood Pre...	141 (1.07%)
Electrolyte And Fluid Balance Condi...	122 (.93%)
Cardiac And Vascular Investigations	120 (.91%)
Enzyme	111 (.84%)
Fatal Outcomes	102 (.78%)
Fungal Infectious	97 (.74%)
Coagulopathies And Bleeding Diathes...	91 (.69%)
Muscle	91 (.69%)
Seizures	89 (.68%)
Central Nervous System Vascular	88 (.67%)
Hematological And Lymphoid Tissue T...	82 (.62%)
Movement Disorders	81 (.62%)
Gastrointestinal Hemorrhages	79 (.6%)
Skin Vascular Abnormalities	75 (.57%)
Oral Soft Tissue Conditions	73 (.56%)
Encephalopathies	68 (.52%)
Physical Examination Topics	68 (.52%)
Medication Errors	67 (.51%)
Administration Site Reactions	65 (.49%)
Glucose Metabolism Disorders	63 (.48%)
Angiedema And Urticaria	62 (.47%)
Hemolyses And Related Conditions	59 (.45%)
Injuries	59 (.45%)
Procedural And Device Related Injur...	59 (.45%)
Viral Infectious	59 (.45%)
Appetite And General Nutritional	58 (.44%)
Gastrointestinal Ulceration And Per...	57 (.43%)
Microbiology And Serology	57 (.43%)
Deliria	55 (.42%)
Pleural	52 (.4%)
Musculoskeletal And Connective Tiss...	51 (.39%)
Heart Failures	50 (.38%)
Vascular	48 (.37%)
Cardiac Disorder Signs	46 (.35%)
Urinary Tract Signs	46 (.35%)
Metabolic, Nutritional And Blood Ga...	43 (.33%)
Product Quality Issues	43 (.33%)
Bronchial Disorders	42 (.32%)
Peritoneal And Retroperitoneal Cond...	41 (.31%)
Lifestyle Issues	39 (.3%)
Water, Electrolyte And Mineral	38 (.29%)
Ocular Infections, Irritations And ...	37 (.28%)
Neuromuscular	36 (.27%)
Spleen, Lymphatic And Reticulendoth...	36 (.27%)
Toxicology And Therapeutic Drug Mon...	35 (.27%)
Joint	34 (.26%)
Exocrine Pancreas Conditions	33 (.25%)
Skin Appendage Conditions	32 (.24%)
Bile Duct	31 (.24%)
Chemical Injury And Poisoning	31 (.24%)
Pericardial	30 (.23%)
Protein And Chemistry Analyses	30 (.23%)
Anxiety Disorders	29 (.22%)
Pulmonary Vascular	29 (.22%)
Upper Respiratory Tract Disorders	29 (.22%)
Vascular Hypertensive	29 (.22%)
Acid-base	28 (.21%)
Headaches	28 (.21%)
Tongue Conditions	25 (.19%)
Gallbladder	24 (.18%)
Gastrointestinal Inflammatory Condi...	24 (.18%)
Immunology And Allergy	24 (.18%)
Disturbances In Thinking	23 (.18%)
Mental Impairment	23 (.18%)
Vascular Hemorrhagic	21 (.16%)
Embolism And Thrombosis	20 (.15%)
Increased Intracranial Pressure And...	20 (.15%)
Vision	20 (.15%)
Skin And Subcutaneous Tissue	19 (.14%)
Therapeutic Procedures And Supporti...	19 (.14%)
Cognitive And Attention Disorders	18 (.14%)
Coronary Artery	18 (.14%)
Gastrointestinal Therapeutic Proced...	18 (.14%)
Investigations, Imaging And Histopa...	18 (.14%)
Peripheral Neuropathies	18 (.14%)
Vulvovaginal Disorders	18 (.14%)
Eye	17 (.13%)
Gastrointestinal Stenosis And Obstr...	17 (.13%)
Immune	17 (.13%)
Leukemias	17 (.13%)

Share/Embed Graph Export Data

This graph shows the top categories of adverse events submitted to the FDA for Zosyn, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Zosyn is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Common Uses of Zosyn According to Those Reporting Adverse Events

Why are people taking Zosyn, according to those reporting adverse events to the FDA?

Pneumonia	592
Product Used For Unknown Indication	469
Infection	280
Drug Use For Unknown Indication	239
Sepsis	236
Pyrexia	158
	Show More
Pneumonia Aspiration	115
Urinary Tract Infection	108
Febrile Neutropenia	105
Infection Prophylaxis	101
Osteomyelitis	90
Cellulitis	75
Pseudomonas Infection	69
Prophylaxis	69
Antibiotic Therapy	60
Antibiotic Prophylaxis	53
Pyelonephritis	50
Bacteraemia	47
Abdominal Infection	45
Pneumonia Bacterial	41
Lung Disorder	35
Cystic Fibrosis	34
Bacterial Infection	32
Septic Shock	32
Lung Infection	28
Peritonitis	27
Bronchopneumonia	26
Staphylococcal Infection	25
Liver Abscess	24
Urosepsis	24
Ill-defined Disorder	21
Lower Respiratory Tract Infection	21
Antifungal Prophylaxis	20
Wound Infection	20
Cholecystitis	19
Evidence Based Treatment	19
Abscess	19
Pyelonephritis Acute	18
Pneumonia Mycoplasmal	17
Upper Respiratory Tract Infection	17
Lung Infection Pseudomonal	15
Bronchitis	15
Skin Infection	14
Abdominal Abscess	14
Respiratory Tract Infection	14
Anti-infective Therapy	14
Drug Therapy	14
Interstitial Lung Disease	14
Neutropenic Sepsis	14
Empyema	12
Condition Aggravated	11

Drug Labels

Label	Labeler	Effective
Zosyn	Cardinal Health	07-JUN-11
Zosyn In Galaxy Containers	Pfizer Pharmaceuticals LLC, Pfizer Pharmaceutical LLC - Piperacillin	08-JUN-12
Zosyn Pharmacy Bulk Package	Pfizer Pharmaceuticals LLC, Pfizer Pharmaceutical LLC - Piperacillin	08-JUN-12
Zosyn	Pfizer Pharmaceuticals LLC, Pfizer Pharmaceutical LLC - Piperacillin	02-JUL-12
Zosyn Pharmacy Bulk Package	Wyeth Piperacillin Division of Wyeth Holdings Corporation, a subsidiary of Pfizer	20-SEP-12
Zosyn	Wyeth Piperacillin Division of Wyeth Holdings Corporation, a subsidiary of Pfizer	20-SEP-12
Zosyn In Galaxy Containers	Wyeth Piperacillin Division of Wyeth Holdings Corporation, a subsidiary of Pfizer	21-SEP-12

Zosyn Case Reports

What Zosyn safety concerns are being reported by doctors and researchers in the medical literature?

About Results

This report contains aggregated drug side effects and adverse events for Zosyn. The data has been pulled from the United States Food and Drug Administration's (US FDA) Adverse Event Reporting System (AERS), a database containing more than 4,000,000 adverse event reports.

DrugCite expands your query using the Unified Medical Language System (UMLS) to include generic drugs and primary active ingredients. While the core of DrugCite's advanced drug filtering algorithm is based on the industry standard UMLS, DrugCite's proprietary filtering system also includes dozens of additional steps to reconcile malformed drug names in the FDA's data.

DrugCite only counts a drug if the submitter of the adverse event indicates that the drug is suspected to have caused the adverse event.

Depending on how the data is aggregated, different counts may occur. When someone submits an adverse event to the FDA, the submitter can attribute multiple adverse events to one or more drugs. For example, an individual taking Paxil could submit the adverse events "anxiety" and "suicidal ideation" for the same individual safety report (ISR). This means when DrugCite aggregates by adverse event, two distinct adverse events are counted in the adverse event graph; once for "anxiety" and again for "suicidal ideation". However, when DrugCite aggregates by individual safety reports irrespective of the details of the adverse events contained within the safety report, the report is only counted once.

Comments

Share your experience with Zosyn.