ZICAM

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Zicam Adverse Events Reported to the FDA Over Time

How are Zicam adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Zicam, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Zicam is flagged as the suspect drug causing the adverse event.

Most Common Zicam Adverse Events Reported to the FDA

What are the most common Zicam adverse events reported to the FDA?

Anosmia	4235 (20.07%)
Ageusia	2919 (13.83%)
Dysgeusia	454 (2.15%)
Nasal Discomfort	341 (1.62%)
Hyposmia	340 (1.61%)
Hypogeusia	253 (1.2%)
Burning Sensation	247 (1.17%)
Completed Suicide	239 (1.13%)
Drug Toxicity	212 (1%)
Overdose	172 (.82%)
Drug Abuse	161 (.76%)
	Show More
Parosmia	156 (.74%)
Intentional Drug Misuse	136 (.64%)
Intentional Overdose	129 (.61%)
Drug Dependence	123 (.58%)
Dyspnoea	120 (.57%)
Cardiac Arrest	112 (.53%)
Headache	112 (.53%)
Drug Interaction	107 (.51%)
Vomiting	103 (.49%)
Respiratory Arrest	100 (.47%)
Blood Pressure Increased	99 (.47%)
Convulsion	95 (.45%)
Multiple Injuries	94 (.45%)
Agitation	89 (.42%)
Cardio-respiratory Arrest	86 (.41%)
Heart Rate Increased	86 (.41%)
Pain	78 (.37%)
Dysarthria	77 (.36%)
Drug Ineffective	75 (.36%)
Loss Of Consciousness	75 (.36%)
Nasal Congestion	74 (.35%)
Serotonin Syndrome	74 (.35%)
Suicide Attempt	74 (.35%)
Death	71 (.34%)
Incorrect Dose Administered	70 (.33%)
Rhinalgia	69 (.33%)
Toxic Anterior Segment Syndrome	69 (.33%)
Dizziness	68 (.32%)
Nausea	67 (.32%)
Psychotic Disorder	67 (.32%)
Aggression	66 (.31%)
Medication Error	64 (.3%)
Product Quality Issue	64 (.3%)
Confusional State	62 (.29%)
Condition Aggravated	61 (.29%)
Depression	61 (.29%)
Incorrect Drug Administration Durat...	60 (.28%)
Palpitations	60 (.28%)
Disturbance In Attention	59 (.28%)
Hypertension	59 (.28%)
Accidental Overdose	58 (.27%)
Abnormal Behaviour	56 (.27%)
Anxiety	56 (.27%)
Pyrexia	56 (.27%)
Cardiac Disorder	55 (.26%)
Hypersensitivity	54 (.26%)
Tachycardia	53 (.25%)
Suicidal Ideation	52 (.25%)
Epistaxis	50 (.24%)
Flat Affect	50 (.24%)
Insomnia	50 (.24%)
Lacrimation Increased	50 (.24%)
Somnolence	50 (.24%)
Atrioventricular Block	48 (.23%)
Ventricular Extrasystoles	48 (.23%)
Heart Rate Irregular	47 (.22%)
Mydriasis	47 (.22%)
Hallucination	46 (.22%)
Pulmonary Oedema	44 (.21%)
Rhabdomyolysis	44 (.21%)
Rhinorrhoea	44 (.21%)
Tangentiality	44 (.21%)
Lethargy	42 (.2%)
Tremor	42 (.2%)
Multiple Drug Overdose	41 (.19%)
Sinus Disorder	41 (.19%)
Blood Creatine Phosphokinase Increa...	40 (.19%)
Extrasystoles	40 (.19%)
Feeling Abnormal	40 (.19%)
Hypotension	40 (.19%)
Malaise	40 (.19%)
Poisoning	40 (.19%)
Wrong Drug Administered	40 (.19%)
Cardiotoxicity	39 (.18%)
Disorientation	38 (.18%)
Drug Exposure During Pregnancy	38 (.18%)
Hallucination, Visual	38 (.18%)
Nasopharyngitis	38 (.18%)
Endophthalmitis	37 (.18%)
Fall	37 (.18%)
Pneumonia	36 (.17%)
Hyperhidrosis	35 (.17%)
Inflammation	34 (.16%)
Multiple Drug Overdose Intentional	34 (.16%)
Chest Pain	33 (.16%)
Coma	33 (.16%)
Drug Abuser	33 (.16%)
Drug Hypersensitivity	33 (.16%)
Euphoric Mood	33 (.16%)
Alcohol Problem	32 (.15%)

Share/Embed Graph Export Data

This graph shows the top adverse events submitted to the FDA for Zicam, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Zicam is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Zicam

What are the most common Zicam adverse events reported to the FDA?

Cranial Nerve Disorders	4751 (22.51%)
Neurological	4564 (21.63%)
Respiratory	920 (4.36%)
Medication Errors	868 (4.11%)
Psychiatric	516 (2.45%)
Cardiac Arrhythmias	505 (2.39%)
Suicidal And Self-injurious Behavio...	391 (1.85%)
Cardiac And Vascular Investigations	378 (1.79%)
Chemical Injury And Poisoning	332 (1.57%)
Upper Respiratory Tract Disorders	300 (1.42%)
Infections - Pathogen Unspecified	290 (1.37%)
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Therapeutic And Nontherapeutic Effe...	286 (1.36%)
Gastrointestinal Signs	272 (1.29%)
Disturbances In Thinking	250 (1.18%)
Injuries	248 (1.18%)
Epidermal And Dermal Conditions	226 (1.07%)
Anxiety Disorders	208 (.99%)
Cardiac Disorder Signs	179 (.85%)
Headaches	145 (.69%)
Muscle	131 (.62%)
Lower Respiratory Tract Disorders	130 (.62%)
Seizures	129 (.61%)
Allergic Conditions	128 (.61%)
Mood Disorders	128 (.61%)
Procedural And Device Related Injur...	122 (.58%)
Deliria	118 (.56%)
Eye	117 (.55%)
Mental Impairment	117 (.55%)
Fatal Outcomes	113 (.54%)
Metabolic, Nutritional And Blood Ga...	101 (.48%)
Depressed Mood Disorders	100 (.47%)
Hepatic And Hepatobiliary	99 (.47%)
Lifestyle Issues	94 (.45%)
Neuromuscular	94 (.45%)
Movement Disorders	91 (.43%)
Vision	91 (.43%)
Product Quality Issues	85 (.4%)
Personality Disorders	78 (.37%)
Ocular Neuromuscular	77 (.36%)
Schizophrenia And Other Psychotic	77 (.36%)
Oral Soft Tissue Conditions	74 (.35%)
Psychiatric And Behavioural Symptom...	70 (.33%)
Coronary Artery	68 (.32%)
Vascular Hypertensive	68 (.32%)
Ocular Infections, Irritations And ...	67 (.32%)
Decreased And Nonspecific Blood Pre...	66 (.31%)
Physical Examination Topics	66 (.31%)
Sleep Disorders	66 (.31%)
Body Temperature Conditions	65 (.31%)
Enzyme	63 (.3%)
Musculoskeletal And Connective Tiss...	61 (.29%)
Toxicology And Therapeutic Drug Mon...	60 (.28%)
Hematology Investigations	58 (.27%)
Electrolyte And Fluid Balance Condi...	57 (.27%)
Appetite And General Nutritional	55 (.26%)
Renal Disorders	54 (.26%)
Tongue Conditions	52 (.25%)
Skin Appendage Conditions	48 (.23%)
Central Nervous System Vascular	45 (.21%)
Water, Electrolyte And Mineral	43 (.2%)
Bronchial Disorders	41 (.19%)
Hepatobiliary	40 (.19%)
Therapeutic Procedures And Supporti...	40 (.19%)
Encephalopathies	39 (.18%)
Vascular	36 (.17%)
Angiedema And Urticaria	35 (.17%)
Gastrointestinal Motility And Defec...	35 (.17%)
Urinary Tract Signs	35 (.17%)
Acid-base	33 (.16%)
Heart Failures	33 (.16%)
Administration Site Reactions	32 (.15%)
Changes In Physical Activity	31 (.15%)
Injuries By Physical Agents	29 (.14%)
Renal And Urinary Tract Investigati...	28 (.13%)
Tissue	28 (.13%)
Myocardial	26 (.12%)
Viral Infectious	26 (.12%)
Salivary Gland Conditions	25 (.12%)
Bacterial Infectious	23 (.11%)
Gastrointestinal Inflammatory Condi...	22 (.1%)
Legal Issues	22 (.1%)
Neonatal And Perinatal Conditions	22 (.1%)
Aural	21 (.1%)
Bone And Joint Injuries	21 (.1%)
Gastrointestinal Hemorrhages	19 (.09%)
Joint	19 (.09%)
Arteriosclerosis, Stenosis, Vascula...	18 (.09%)
Increased Intracranial Pressure And...	18 (.09%)
Neurological, Special Senses And Ps...	18 (.09%)
Skin Vascular Abnormalities	17 (.08%)
Dental And Gingival Conditions	16 (.08%)
Hearing	16 (.08%)
Inner Ear And Viiith Cranial Nerve	16 (.08%)
Abortions And Stillbirth	14 (.07%)
Glucose Metabolism Disorders	13 (.06%)
Placental, Amniotic And Cavity Diso...	13 (.06%)
Pleural	13 (.06%)
Dissociative	12 (.06%)
Maternal Complications Of Labour An...	12 (.06%)
Obstetric And Gynecological Therape...	12 (.06%)
Platelet	12 (.06%)

Share/Embed Graph Export Data

This graph shows the top categories of adverse events submitted to the FDA for Zicam, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Zicam is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Common Uses of Zicam According to Those Reporting Adverse Events

Why are people taking Zicam, according to those reporting adverse events to the FDA?

Nasopharyngitis	1731
Drug Use For Unknown Indication	387
Product Used For Unknown Indication	335
Nasal Congestion	328
Cough	289
Upper Respiratory Tract Infection	84
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Preoperative Care	83
Influenza	80
Prophylaxis	78
Sinus Congestion	66
Hypersensitivity	62
Hypotension	61
Mydriasis	54
Suicide Attempt	54
Sinus Disorder	51
Sinusitis	45
Cataract Operation	42
Multiple Allergies	37
Drug Abuse	31
Rhinorrhoea	30
Seasonal Allergy	30
Ill-defined Disorder	29
Intentional Overdose	29
Influenza Like Illness	23
Oropharyngeal Pain	23
Anosmia	23
Pyrexia	22
Insomnia	21
Ophthalmological Examination	21
Dyspnoea	19
Off Label Use	18
Headache	17
Accidental Exposure	17
Bronchitis	16
Sinus Headache	15
Anaesthesia	14
Reversible Ischaemic Neurological D...	14
Blood Pressure Management	13
Malaise	13
Intentional Drug Misuse	13
Pharyngolaryngeal Pain	12
Drug Exposure During Pregnancy	11
Sleep Disorder	11
Antitussive Therapy	11
Pain	11
Respiratory Tract Infection	10
Viral Infection	10
Sneezing	10
Feeling Cold	9
Euphoric Mood	9
Upper Respiratory Tract Inflammatio...	8

Drug Labels

Label	Labeler	Effective
Zicam	Matrixx Initiatives, Inc.	21-DEC-09
Zicam	Matrixx Initiatives, Inc.	21-DEC-09
Zicam	Matrixx Initiatives, Inc.	28-DEC-09
Zicam	Matrixx Initiatives, Inc.	28-DEC-09
Zicamcough Max	Matrixx Initiatives, Inc.	28-DEC-09
Zicam	Matrixx Initiatives, Inc.	28-DEC-09
Zicam	Matrixx Initiatives, Inc.	28-DEC-09
Zicam	Matrixx Initiatives, Inc.	28-DEC-09
Zicam	Matrixx Initiatives, Inc.	28-DEC-09
Zicam	Matrixx Initiatives, Inc.	29-DEC-09
Zicam	Matrixx Initiatives, Inc.	29-DEC-09
Zicam Allergy Relief	Matrixx Initiatives, Inc.	29-JUN-10
Zicamnaturals Cough Suppressant	Matrixx Initiatives, Inc.	19-NOV-10
Zicam	Matrixx Initiatives, Inc.	29-DEC-10
Zicamcold Remedy	Matrixx Initiatives, Inc.	29-DEC-10
Zicam	Matrixx Initiatives, Inc.	29-DEC-10
Zicam	Matrixx Initiatives, Inc.	30-DEC-10
Zicamcold Remedy Zavors	Matrixx Initiatives, Inc.	30-DEC-10
Zicam	Matrixx Initiatives, Inc.	06-JAN-11
Zicam	Matrixx Initiatives, Inc.	12-JAN-11
Zicam Naturals Cough Suppressant	Matrixx Initiatives, Inc.	03-FEB-11
Zicam	Matrixx Initiatives, Inc.	15-FEB-11
Zicam Cold Remedy Rapidmelts With Echinacea	Matrixx Initiatives, Inc.	12-SEP-11
Zicamcold Remedy Rapidmelts Citrus	Matrixx Initiatives, Inc.	20-SEP-11
Zicam Cold Remedy Ultra Rapidmelts	Matrixx Initiatives, Inc.	07-OCT-11
Zicamcold Remedy Ultra Rapidmelts	Matrixx Initiatives, Inc.	07-OCT-11
Zicam Ultra Cold Remedy	Matrixx Initiatives, Inc.	08-JUN-12
Zicam Cold Remedy Rapidmelts	Matrixx Initiatives, Inc.	09-JUL-12
Zicam Allergy Relief	Matrixx Initiatives, Inc.	19-JUL-12
Zicam Cold Remedy Plus Mist	Matrixx Initiatives, Inc.	20-JUL-12
Zicam Ultra Cold Remedy	Matrixx Initiatives, Inc.	23-JUL-12
Zicam Naturals Cough Suppressant	Matrixx Initiatives, Inc.	23-JUL-12
Zicam Ultra Cold Remedy Rapidmelts	Matrixx Initiatives, Inc.	16-AUG-12
Zicam Ultra Cold Remedy Rapidmelts	Matrixx Initiatives, Inc.	16-AUG-12
Zicam Cold Remedy Ultra Rapidmelts	Matrixx Initiatives, Inc.	26-FEB-13
Zicam Cold Remedy Liqui-loz	Matrixx Initiatives, Inc.	27-FEB-13
Zicam Cold Remedy Rapidmelts	Matrixx Initiatives, Inc.	27-FEB-13
Zicam Cold Remedy Ultra Rapidmelts	Matrixx Initiatives, Inc.	20-MAR-13
Zicam Cold Remedy Oral Mist	Matrixx Initiatives, Inc.	29-MAR-13
Zicam Cold Remedy Oral Mist	Matrixx Initiatives, Inc.	29-MAR-13
Zicam	Matrixx Initiatives, Inc.	04-APR-13
Zicam Naturals Cough Suppressant	Matrixx Initiatives, Inc.	04-APR-13
Zicam Allergy Relief	Matrixx Initiatives, Inc.	04-APR-13
Zicam	Matrixx Initiatives, Inc.	04-APR-13

Zicam Case Reports

What Zicam safety concerns are being reported by doctors and researchers in the medical literature?

About Results

This report contains aggregated drug side effects and adverse events for Zicam. The data has been pulled from the United States Food and Drug Administration's (US FDA) Adverse Event Reporting System (AERS), a database containing more than 4,000,000 adverse event reports.

DrugCite expands your query using the Unified Medical Language System (UMLS) to include generic drugs and primary active ingredients. While the core of DrugCite's advanced drug filtering algorithm is based on the industry standard UMLS, DrugCite's proprietary filtering system also includes dozens of additional steps to reconcile malformed drug names in the FDA's data.

DrugCite only counts a drug if the submitter of the adverse event indicates that the drug is suspected to have caused the adverse event.

Depending on how the data is aggregated, different counts may occur. When someone submits an adverse event to the FDA, the submitter can attribute multiple adverse events to one or more drugs. For example, an individual taking Paxil could submit the adverse events "anxiety" and "suicidal ideation" for the same individual safety report (ISR). This means when DrugCite aggregates by adverse event, two distinct adverse events are counted in the adverse event graph; once for "anxiety" and again for "suicidal ideation". However, when DrugCite aggregates by individual safety reports irrespective of the details of the adverse events contained within the safety report, the report is only counted once.

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