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VYTORIN

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Vytorin Adverse Events Reported to the FDA Over Time

How are Vytorin adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Vytorin, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Vytorin is flagged as the suspect drug causing the adverse event.

Most Common Vytorin Adverse Events Reported to the FDA

What are the most common Vytorin adverse events reported to the FDA?

Rhabdomyolysis
559 (4.26%)
Myalgia
521 (3.97%)
Blood Creatine Phosphokinase Increa...
251 (1.91%)
Pain In Extremity
210 (1.6%)
Asthenia
204 (1.56%)
Pain
189 (1.44%)
Muscle Spasms
183 (1.4%)
Muscular Weakness
180 (1.37%)
Arthralgia
170 (1.3%)
Myocardial Infarction
140 (1.07%)
Nausea
140 (1.07%)
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Fatigue
137 (1.05%)
Renal Failure Acute
135 (1.03%)
Chest Pain
117 (.89%)
Cerebrovascular Accident
113 (.86%)
Renal Failure
111 (.85%)
Diarrhoea
106 (.81%)
Alanine Aminotransferase Increased
105 (.8%)
Gait Disturbance
105 (.8%)
Dizziness
100 (.76%)
Aspartate Aminotransferase Increase...
99 (.76%)
Back Pain
97 (.74%)
Dyspnoea
95 (.72%)
Drug Ineffective
90 (.69%)
Fall
89 (.68%)
Anxiety
88 (.67%)
Pancreatitis
88 (.67%)
Drug Interaction
85 (.65%)
Headache
81 (.62%)
Vomiting
81 (.62%)
Hepatic Enzyme Increased
80 (.61%)
Oedema Peripheral
66 (.5%)
Adverse Event
65 (.5%)
Arterial Occlusive Disease
59 (.45%)
Blood Cholesterol Increased
57 (.43%)
Malaise
57 (.43%)
Muscle Disorder
56 (.43%)
Arteriosclerosis
55 (.42%)
Cardiac Disorder
55 (.42%)
Weight Decreased
55 (.42%)
Depression
54 (.41%)
Insomnia
54 (.41%)
Abasia
53 (.4%)
Abdominal Pain
52 (.4%)
Rash
52 (.4%)
Myopathy
50 (.38%)
Feeling Abnormal
49 (.37%)
Pyrexia
48 (.37%)
Death
47 (.36%)
Paraesthesia
47 (.36%)
Myositis
46 (.35%)
Hypertension
45 (.34%)
Abdominal Pain Upper
44 (.34%)
Blood Creatinine Increased
44 (.34%)
Cholelithiasis
44 (.34%)
Liver Function Test Abnormal
44 (.34%)
Hepatitis
43 (.33%)
Pneumonia
43 (.33%)
Musculoskeletal Pain
42 (.32%)
Wrong Technique In Drug Usage Proce...
42 (.32%)
Anorexia
40 (.31%)
Movement Disorder
40 (.31%)
Hyperhidrosis
39 (.3%)
Pruritus
39 (.3%)
Palpitations
38 (.29%)
Amnesia
36 (.27%)
Constipation
36 (.27%)
Angina Pectoris
35 (.27%)
Muscle Atrophy
35 (.27%)
Blood Glucose Increased
34 (.26%)
Coronary Artery Disease
34 (.26%)
Anaemia
33 (.25%)
Hepatic Failure
32 (.24%)
Hypoaesthesia
32 (.24%)
Syncope
32 (.24%)
Alopecia
31 (.24%)
Dehydration
30 (.23%)
Hepatic Steatosis
30 (.23%)
Memory Impairment
29 (.22%)
Pancreatitis Acute
29 (.22%)
Vision Blurred
29 (.22%)
Blood Alkaline Phosphatase Increase...
28 (.21%)
Blood Bilirubin Increased
28 (.21%)
Convulsion
28 (.21%)
Influenza Like Illness
28 (.21%)
Loss Of Consciousness
28 (.21%)
Musculoskeletal Stiffness
28 (.21%)
Urinary Tract Infection
28 (.21%)
Dysphagia
27 (.21%)
International Normalised Ratio Incr...
27 (.21%)
Urticaria
27 (.21%)
Activities Of Daily Living Impaired
26 (.2%)
Chromaturia
26 (.2%)
Joint Swelling
26 (.2%)
Liver Disorder
26 (.2%)
Medication Error
26 (.2%)
Overdose
26 (.2%)
Renal Disorder
26 (.2%)
Weight Increased
26 (.2%)
Acute Myocardial Infarction
25 (.19%)
Blood Pressure Increased
25 (.19%)

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This graph shows the top adverse events submitted to the FDA for Vytorin, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Vytorin is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Vytorin

What are the most common Vytorin adverse events reported to the FDA?

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This graph shows the top categories of adverse events submitted to the FDA for Vytorin, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Vytorin is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Common Uses of Vytorin According to Those Reporting Adverse Events

Why are people taking Vytorin, according to those reporting adverse events to the FDA?

Blood Cholesterol Increased
1712
Blood Cholesterol
641
Hypercholesterolaemia
639
Product Used For Unknown Indication
570
Hyperlipidaemia
508
Drug Use For Unknown Indication
355
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Dyslipidaemia
158
Blood Cholesterol Abnormal
103
Acute Coronary Syndrome
102
Coronary Artery Disease
58
Blood Triglycerides Increased
56
Hypertension
48
Low Density Lipoprotein Increased
44
Lipids Increased
30
Cardiac Disorder
29
Type Iia Hyperlipidaemia
20
Blood Cholesterol Decreased
12
Hypertriglyceridaemia
12
Blood Pressure
10
Myocardial Infarction
10
Metabolic Disorder
10
Ill-defined Disorder
9
Low Density Lipoprotein
9
Blood Triglycerides Abnormal
8
Blood Pressure Increased
7
Diabetes Mellitus
7
Cerebrovascular Accident Prophylaxi...
6
Aortic Stenosis
5
Arteriosclerosis
5
Coronary Angioplasty
5
Lipids
5
Prophylaxis
5
Blood Triglycerides
4
Mixed Hyperlipidaemia
4
Cardiac Operation
4
Carotid Artery Disease
3
Neoplasm Malignant
3
Cardiovascular Event Prophylaxis
3
High Density Lipoprotein Decreased
3
Low Density Lipoprotein Decreased
3
Lipids Abnormal
3
Unevaluable Event
3
Coronary Arterial Stent Insertion
3
Drug Level
2
Renal Disorder
2
Ischaemic Heart Disease Prophylaxis
2
Transient Ischaemic Attack
2
Arteriosclerosis Coronary Artery
2
Coronary Artery Bypass
2
Protein Urine
2
Depression
2

Drug Labels

LabelLabelerEffective
VytorinLake Erie Medical DBA Quality Care Products LLC27-AUG-10
VytorinLake Erie Medical DBA Quality Care Products LLC01-NOV-10
VytorinRebel Distributors Corp01-DEC-10
VytorinPD-Rx Pharmaceuticals, Inc.01-NOV-11
VytorinPD-Rx Pharmaceuticals, Inc.24-JAN-12
VytorinPhysicians Total Care, Inc.06-SEP-12
VytorinMerck Sharp & Dohme Corp.13-FEB-13

Vytorin Case Reports

What Vytorin safety concerns are being reported by doctors and researchers in the medical literature?

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About Results

This report contains aggregated drug side effects and adverse events for Vytorin. The data has been pulled from the United States Food and Drug Administration's (US FDA) Adverse Event Reporting System (AERS), a database containing more than 4,000,000 adverse event reports.

DrugCite expands your query using the Unified Medical Language System (UMLS) to include generic drugs and primary active ingredients. While the core of DrugCite's advanced drug filtering algorithm is based on the industry standard UMLS, DrugCite's proprietary filtering system also includes dozens of additional steps to reconcile malformed drug names in the FDA's data.

DrugCite only counts a drug if the submitter of the adverse event indicates that the drug is suspected to have caused the adverse event.

Depending on how the data is aggregated, different counts may occur. When someone submits an adverse event to the FDA, the submitter can attribute multiple adverse events to one or more drugs. For example, an individual taking Paxil could submit the adverse events "anxiety" and "suicidal ideation" for the same individual safety report (ISR). This means when DrugCite aggregates by adverse event, two distinct adverse events are counted in the adverse event graph; once for "anxiety" and again for "suicidal ideation". However, when DrugCite aggregates by individual safety reports irrespective of the details of the adverse events contained within the safety report, the report is only counted once.

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