PROPOXYPHENE

Propoxyphene Adverse Events Reported to the FDA Over Time

How are Propoxyphene adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Propoxyphene, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Propoxyphene is flagged as the suspect drug causing the adverse event.

Most Common Propoxyphene Adverse Events Reported to the FDA

What are the most common Propoxyphene adverse events reported to the FDA?

Cardio-respiratory Arrest	2181 (9.5%)
Myocardial Infarction	2110 (9.19%)
Arrhythmia	2106 (9.18%)
Cardiac Disorder	2103 (9.16%)
Cardiovascular Disorder	2039 (8.88%)
Sudden Cardiac Death	886 (3.86%)
Completed Suicide	692 (3.01%)
Cardiac Arrest	352 (1.53%)
Respiratory Arrest	332 (1.45%)
Injury	232 (1.01%)
Dizziness	175 (.76%)
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Death	171 (.75%)
Drug Ineffective	144 (.63%)
Drug Toxicity	129 (.56%)
Pain	128 (.56%)
Nausea	127 (.55%)
Dyspnoea	116 (.51%)
Palpitations	109 (.47%)
Atrial Fibrillation	107 (.47%)
Chest Pain	104 (.45%)
Multiple Drug Overdose	99 (.43%)
Intentional Drug Misuse	95 (.41%)
Multiple Drug Overdose Intentional	91 (.4%)
Nervous System Disorder	88 (.38%)
Overdose	86 (.37%)
Vomiting	86 (.37%)
Movement Disorder	84 (.37%)
Poisoning	84 (.37%)
Loss Of Consciousness	78 (.34%)
Drug Abuse	76 (.33%)
Somnolence	76 (.33%)
Confusional State	68 (.3%)
Cerebrovascular Accident	66 (.29%)
Fall	66 (.29%)
Asthenia	62 (.27%)
Fatigue	61 (.27%)
Weight Decreased	59 (.26%)
Depression	58 (.25%)
Drug Interaction	58 (.25%)
Hypotension	56 (.24%)
Headache	54 (.24%)
Heart Rate Irregular	53 (.23%)
Anhedonia	50 (.22%)
Emotional Distress	48 (.21%)
Heart Rate Increased	48 (.21%)
Alanine Aminotransferase Increased	47 (.2%)
Back Pain	47 (.2%)
Hallucination	47 (.2%)
Abdominal Pain Upper	46 (.2%)
Economic Problem	46 (.2%)
Drug Hypersensitivity	45 (.2%)
Product Quality Issue	45 (.2%)
Malaise	44 (.19%)
Tachycardia	44 (.19%)
Tremor	44 (.19%)
Aspartate Aminotransferase Increase...	42 (.18%)
Deformity	42 (.18%)
Medication Error	42 (.18%)
Pruritus	42 (.18%)
Bradycardia	41 (.18%)
Diarrhoea	41 (.18%)
Feeling Abnormal	41 (.18%)
Hyperhidrosis	41 (.18%)
Hyponatraemia	41 (.18%)
Syncope	41 (.18%)
Pulmonary Oedema	40 (.17%)
Fear Of Death	39 (.17%)
Rash	39 (.17%)
Cardiac Failure Congestive	38 (.17%)
Insomnia	38 (.17%)
Amnesia	37 (.16%)
Blood Alkaline Phosphatase Increase...	37 (.16%)
Pain In Extremity	37 (.16%)
Anxiety	36 (.16%)
Family Stress	36 (.16%)
General Physical Health Deteriorati...	36 (.16%)
Constipation	35 (.15%)
Gait Disturbance	33 (.14%)
Disorientation	32 (.14%)
Drug Abuser	32 (.14%)
Oedema Peripheral	31 (.14%)
Intentional Overdose	30 (.13%)
Weight Increased	30 (.13%)
Arthralgia	29 (.13%)
Blood Pressure Increased	29 (.13%)
Suicidal Ideation	29 (.13%)
Accidental Overdose	28 (.12%)
Multiple Injuries	28 (.12%)
Pyrexia	28 (.12%)
Road Traffic Accident	28 (.12%)
Convulsion	27 (.12%)
Abdominal Discomfort	26 (.11%)
Condition Aggravated	26 (.11%)
Myalgia	26 (.11%)
Mitral Valve Incompetence	25 (.11%)
Sudden Death	25 (.11%)
Ventricular Extrasystoles	25 (.11%)
Cardiac Failure	24 (.1%)
Contusion	24 (.1%)
Drug Dependence	24 (.1%)
Gamma-glutamyltransferase Increased	24 (.1%)

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This graph shows the top adverse events submitted to the FDA for Propoxyphene, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Propoxyphene is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Propoxyphene

What are the most common Propoxyphene adverse events reported to the FDA?

Cardiac Arrhythmias	5031 (21.92%)
Cardiac Disorder Signs	4261 (18.56%)
Coronary Artery	2152 (9.38%)
Fatal Outcomes	1106 (4.82%)
Suicidal And Self-injurious Behavio...	742 (3.23%)
Neurological	680 (2.96%)
Respiratory	593 (2.58%)
Injuries	473 (2.06%)
Medication Errors	468 (2.04%)
Gastrointestinal Signs	342 (1.49%)
Psychiatric	262 (1.14%)
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Therapeutic And Nontherapeutic Effe...	259 (1.13%)
Chemical Injury And Poisoning	257 (1.12%)
Cardiac And Vascular Investigations	240 (1.05%)
Epidermal And Dermal Conditions	217 (.95%)
Anxiety Disorders	182 (.79%)
Hepatic And Hepatobiliary	167 (.73%)
Hepatobiliary	151 (.66%)
Movement Disorders	150 (.65%)
Lifestyle Issues	139 (.61%)
Infections - Pathogen Unspecified	129 (.56%)
Deliria	123 (.54%)
Musculoskeletal And Connective Tiss...	122 (.53%)
Depressed Mood Disorders	118 (.51%)
Disturbances In Thinking	114 (.5%)
Lower Respiratory Tract Disorders	112 (.49%)
Physical Examination Topics	107 (.47%)
Central Nervous System Vascular	103 (.45%)
Mental Impairment	102 (.44%)
Sleep Disorders	101 (.44%)
Gastrointestinal Motility And Defec...	92 (.4%)
Mood Disorders	92 (.4%)
Hematology Investigations	86 (.37%)
Electrolyte And Fluid Balance Condi...	81 (.35%)
Allergic Conditions	80 (.35%)
Decreased And Nonspecific Blood Pre...	78 (.34%)
Cardiac Valve	77 (.34%)
Joint	73 (.32%)
Appetite And General Nutritional	69 (.3%)
Muscle	68 (.3%)
Skin Appendage Conditions	65 (.28%)
Urinary Tract Signs	65 (.28%)
Myocardial	64 (.28%)
Product Quality Issues	64 (.28%)
Bone And Joint Injuries	63 (.27%)
Headaches	63 (.27%)
Heart Failures	63 (.27%)
Toxicology And Therapeutic Drug Mon...	55 (.24%)
Gastrointestinal Inflammatory Condi...	52 (.23%)
Enzyme	51 (.22%)
Renal Disorders	48 (.21%)
Economic And Housing Issues	47 (.2%)
Renal And Urinary Tract Investigati...	47 (.2%)
Metabolic, Nutritional And Blood Ga...	46 (.2%)
Gastrointestinal Conditions	45 (.2%)
Body Temperature Conditions	44 (.19%)
Family Issues	38 (.17%)
Cardiac Therapeutic Procedures	37 (.16%)
Water, Electrolyte And Mineral	36 (.16%)
Musculoskeletal And Connective Tiss...	35 (.15%)
Vision	35 (.15%)
Gastrointestinal Hemorrhages	34 (.15%)
Peripheral Neuropathies	33 (.14%)
Personality Disorders	33 (.14%)
Seizures	32 (.14%)
Psychiatric And Behavioural Symptom...	31 (.14%)
Gastrointestinal Ulceration And Per...	30 (.13%)
Encephalopathies	29 (.13%)
Bacterial Infectious	28 (.12%)
Therapeutic Procedures And Supporti...	28 (.12%)
Ocular Neuromuscular	27 (.12%)
Procedural And Device Related Injur...	27 (.12%)
Inner Ear And Viiith Cranial Nerve	25 (.11%)
Bone And Joint Therapeutic Procedur...	24 (.1%)
Glucose Metabolism Disorders	24 (.1%)
Angiedema And Urticaria	22 (.1%)
Bronchial Disorders	21 (.09%)
Lipid Analyses	21 (.09%)
Pleural	21 (.09%)
Pulmonary Vascular	20 (.09%)
Tissue	20 (.09%)
Vascular Hypertensive	20 (.09%)
Anemias Nonhemolytic And Marrow Dep...	19 (.08%)
Bladder And Bladder Neck Disorders	19 (.08%)
Bone Disorders	19 (.08%)
Administration Site Reactions	18 (.08%)
Salivary Gland Conditions	18 (.08%)
Acid-base	17 (.07%)
Venous Varices	17 (.07%)
Viral Infectious	16 (.07%)
White Blood Cell	16 (.07%)
Skin Vascular Abnormalities	15 (.07%)
Vascular	15 (.07%)
Vascular Therapeutic Procedures	15 (.07%)
Arteriosclerosis, Stenosis, Vascula...	14 (.06%)
Increased Intracranial Pressure And...	14 (.06%)
Sexual Function And Fertility	14 (.06%)
Coagulopathies And Bleeding Diathes...	13 (.06%)
Eye	13 (.06%)
Embolism And Thrombosis	12 (.05%)
Gallbladder	12 (.05%)

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This graph shows the top categories of adverse events submitted to the FDA for Propoxyphene, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Propoxyphene is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.