PENTOXIFYLLINE

Pentoxifylline Adverse Events Reported to the FDA Over Time

How are Pentoxifylline adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Pentoxifylline, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Pentoxifylline is flagged as the suspect drug causing the adverse event.

Most Common Pentoxifylline Adverse Events Reported to the FDA

What are the most common Pentoxifylline adverse events reported to the FDA?

International Normalised Ratio Incr...	17 (1.74%)
Renal Failure Acute	16 (1.64%)
Drug Ineffective	14 (1.44%)
Drug Interaction	12 (1.23%)
Gastrointestinal Haemorrhage	12 (1.23%)
Hypotension	12 (1.23%)
Interstitial Lung Disease	12 (1.23%)
Anaemia	11 (1.13%)
Asthenia	11 (1.13%)
Dizziness	11 (1.13%)
Pyrexia	11 (1.13%)
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Alanine Aminotransferase Increased	10 (1.03%)
Overdose	10 (1.03%)
Thrombocytopenia	10 (1.03%)
Coma	9 (.92%)
Dehydration	9 (.92%)
Pulmonary Fibrosis	9 (.92%)
Cardiac Failure	8 (.82%)
Confusional State	8 (.82%)
Petechiae	8 (.82%)
Epistaxis	7 (.72%)
Haemoglobin Decreased	7 (.72%)
Oedema Peripheral	7 (.72%)
Sepsis	7 (.72%)
Cerebrovascular Accident	6 (.62%)
Condition Aggravated	6 (.62%)
Convulsion	6 (.62%)
Haematuria	6 (.62%)
Lung Disorder	6 (.62%)
Metabolic Acidosis	6 (.62%)
Mitral Valve Incompetence	6 (.62%)
Peripheral Vascular Disorder	6 (.62%)
Rectal Haemorrhage	6 (.62%)
Renal Failure	6 (.62%)
Blood Creatinine Increased	5 (.51%)
Cardiac Tamponade	5 (.51%)
Cerebral Haemorrhage	5 (.51%)
Contusion	5 (.51%)
Creatinine Renal Clearance Decrease...	5 (.51%)
Deafness	5 (.51%)
Dry Skin	5 (.51%)
Gingival Disorder	5 (.51%)
Haematoma	5 (.51%)
Intentional Overdose	5 (.51%)
Mental Status Changes	5 (.51%)
Pain In Extremity	5 (.51%)
Pleural Effusion	5 (.51%)
Prostate Cancer Recurrent	5 (.51%)
Respiratory Failure	5 (.51%)
Sinusitis	5 (.51%)
Syncope	5 (.51%)
Vasculitis	5 (.51%)
Adrenal Adenoma	4 (.41%)
Aortic Valve Incompetence	4 (.41%)
Bladder Mass	4 (.41%)
Blood Glucose Increased	4 (.41%)
Blood Pressure Increased	4 (.41%)
Chest Pain	4 (.41%)
Cough	4 (.41%)
Deep Vein Thrombosis	4 (.41%)
Dyspnoea	4 (.41%)
Fall	4 (.41%)
Gamma-glutamyltransferase Increased	4 (.41%)
Gastrointestinal Disorder	4 (.41%)
Headache	4 (.41%)
Hypokalaemia	4 (.41%)
Hyponatraemia	4 (.41%)
Liver Function Test Abnormal	4 (.41%)
Malaise	4 (.41%)
Medication Error	4 (.41%)
Muscle Haemorrhage	4 (.41%)
Muscle Spasms	4 (.41%)
Nasopharyngitis	4 (.41%)
Nuclear Magnetic Resonance Imaging ...	4 (.41%)
Pain	4 (.41%)
Pulmonary Arterial Hypertension	4 (.41%)
Pulmonary Embolism	4 (.41%)
Respiratory Distress	4 (.41%)
Sedation	4 (.41%)
Urinary Tract Infection	4 (.41%)
Uveitis	4 (.41%)
Abdominal Discomfort	3 (.31%)
Abdominal Pain	3 (.31%)
Abdominal Wall Haematoma	3 (.31%)
Agitation	3 (.31%)
Anticonvulsant Drug Level Below The...	3 (.31%)
Cholestasis	3 (.31%)
Crepitations	3 (.31%)
Cytolytic Hepatitis	3 (.31%)
Drug Exposure During Pregnancy	3 (.31%)
Drug Level Increased	3 (.31%)
Dyspnoea Exertional	3 (.31%)
Electrocardiogram Qt Prolonged	3 (.31%)
General Physical Health Deteriorati...	3 (.31%)
Haematocrit Decreased	3 (.31%)
Haemorrhage	3 (.31%)
Hypertension	3 (.31%)
Hypoxia	3 (.31%)
Inflammation	3 (.31%)
International Normalised Ratio Decr...	3 (.31%)
Lethargy	3 (.31%)

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This graph shows the top adverse events submitted to the FDA for Pentoxifylline, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Pentoxifylline is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Pentoxifylline

What are the most common Pentoxifylline adverse events reported to the FDA?

Hematology Investigations	52 (5.33%)
Neurological	47 (4.82%)
Respiratory	35 (3.59%)
Therapeutic And Nontherapeutic Effe...	31 (3.18%)
Lower Respiratory Tract Disorders	29 (2.97%)
Epidermal And Dermal Conditions	26 (2.67%)
Infections - Pathogen Unspecified	26 (2.67%)
Renal Disorders	26 (2.67%)
Gastrointestinal Hemorrhages	21 (2.15%)
Hepatobiliary	21 (2.15%)
Central Nervous System Vascular	20 (2.05%)
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Electrolyte And Fluid Balance Condi...	20 (2.05%)
Medication Errors	20 (2.05%)
Decreased And Nonspecific Blood Pre...	17 (1.74%)
Skin Vascular Abnormalities	17 (1.74%)
Cardiac And Vascular Investigations	16 (1.64%)
Renal And Urinary Tract Investigati...	16 (1.64%)
Anemias Nonhemolytic And Marrow Dep...	15 (1.54%)
Cardiac Valve	15 (1.54%)
Injuries	15 (1.54%)
Gastrointestinal Signs	14 (1.44%)
Body Temperature Conditions	11 (1.13%)
Cardiac Arrhythmias	11 (1.13%)
Deliria	11 (1.13%)
Hepatic And Hepatobiliary	10 (1.03%)
Mental Impairment	10 (1.03%)
Muscle	10 (1.03%)
Platelet	10 (1.03%)
Upper Respiratory Tract Disorders	10 (1.03%)
Metabolic, Nutritional And Blood Ga...	9 (.92%)
Musculoskeletal And Connective Tiss...	9 (.92%)
Pericardial	9 (.92%)
Heart Failures	8 (.82%)
Ocular Infections, Irritations And ...	8 (.82%)
Pulmonary Vascular	8 (.82%)
Vascular Hemorrhagic	8 (.82%)
Acid-base	7 (.72%)
Gastrointestinal Conditions	7 (.72%)
Psychiatric	7 (.72%)
Seizures	7 (.72%)
Toxicology And Therapeutic Drug Mon...	7 (.72%)
Urinary Tract Signs	7 (.72%)
Vascular	7 (.72%)
Vision	7 (.72%)
Movement Disorders	6 (.62%)
Myocardial	6 (.62%)
Vascular Inflammations	6 (.62%)
White Blood Cell	6 (.62%)
Anxiety Disorders	5 (.51%)
Dental And Gingival Conditions	5 (.51%)
Embolism And Thrombosis	5 (.51%)
Gastrointestinal Motility And Defec...	5 (.51%)
Hearing	5 (.51%)
Pleural	5 (.51%)
Reproductive Neoplasms Male Maligna...	5 (.51%)
Allergic Conditions	4 (.41%)
Bacterial Infectious	4 (.41%)
Bladder And Bladder Neck Disorders	4 (.41%)
Bone And Joint Injuries	4 (.41%)
Chemical Injury And Poisoning	4 (.41%)
Endocrine Neoplasms Benign	4 (.41%)
Headaches	4 (.41%)
Investigations, Imaging And Histopa...	4 (.41%)
Abdominal Hernias And Other Abdomin...	3 (.31%)
Appetite And General Nutritional	3 (.31%)
Bronchial Disorders	3 (.31%)
Cardiac And Vascular Disorders Cong...	3 (.31%)
Coronary Artery	3 (.31%)
Disturbances In Thinking	3 (.31%)
Encephalopathies	3 (.31%)
Fatal Outcomes	3 (.31%)
Gastrointestinal Inflammatory Condi...	3 (.31%)
Gastrointestinal Ulceration And Per...	3 (.31%)
Lifestyle Issues	3 (.31%)
Neonatal And Perinatal Conditions	3 (.31%)
Nephropathies	3 (.31%)
Physical Examination Topics	3 (.31%)
Skin Appendage Conditions	3 (.31%)
Suicidal And Self-injurious Behavio...	3 (.31%)
Therapeutic Procedures And Supporti...	3 (.31%)
Vascular Hypertensive	3 (.31%)
Water, Electrolyte And Mineral	3 (.31%)
Angiedema And Urticaria	2 (.21%)
Arteriosclerosis, Stenosis, Vascula...	2 (.21%)
Bone, Calcium, Magnesium And Phosph...	2 (.21%)
Cardiac Disorder Signs	2 (.21%)
Coagulopathies And Bleeding Diathes...	2 (.21%)
Exocrine Pancreas Conditions	2 (.21%)
Glucose Metabolism Disorders	2 (.21%)
Immune	2 (.21%)
Immunology And Allergy	2 (.21%)
Increased Intracranial Pressure And...	2 (.21%)
Joint	2 (.21%)
Renal And Urinary Tract Neoplasms M...	2 (.21%)
Retina, Choroid And Vitreous Hemorr...	2 (.21%)
Sleep Disturbances	2 (.21%)
Structural Brain	2 (.21%)
Thoracic Disorders	2 (.21%)
Tissue	2 (.21%)
Administration Site Reactions	1 (.1%)
Aural	1 (.1%)

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This graph shows the top categories of adverse events submitted to the FDA for Pentoxifylline, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Pentoxifylline is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.