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NOXAFIL

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Noxafil Adverse Events Reported to the FDA Over Time

How are Noxafil adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Noxafil, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Noxafil is flagged as the suspect drug causing the adverse event.

Most Common Noxafil Adverse Events Reported to the FDA

What are the most common Noxafil adverse events reported to the FDA?

Drug Interaction
40 (2.88%)
Drug Ineffective
20 (1.44%)
Condition Aggravated
19 (1.37%)
Aspergillosis
18 (1.3%)
Sinoatrial Block
18 (1.3%)
Cardiac Arrest
16 (1.15%)
Atrioventricular Block Second Degre...
13 (.94%)
Renal Failure Acute
13 (.94%)
Hepatotoxicity
12 (.87%)
Convulsion
11 (.79%)
Nodal Arrhythmia
11 (.79%)
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Respiratory Failure
11 (.79%)
Sinus Tachycardia
11 (.79%)
Acute Hepatic Failure
10 (.72%)
Arrhythmia
10 (.72%)
Blood Alkaline Phosphatase Increase...
10 (.72%)
Death
10 (.72%)
Rash
10 (.72%)
Sepsis
10 (.72%)
Septic Shock
10 (.72%)
Thrombocytopenia
10 (.72%)
Bradycardia
9 (.65%)
Bronchopulmonary Aspergillosis
9 (.65%)
Congestive Cardiomyopathy
9 (.65%)
Diarrhoea
9 (.65%)
Fusarium Infection
9 (.65%)
Gamma-glutamyltransferase Increased
9 (.65%)
Graft Versus Host Disease
9 (.65%)
Headache
9 (.65%)
Neutropenia
9 (.65%)
Pyrexia
9 (.65%)
Sinus Bradycardia
9 (.65%)
Vomiting
9 (.65%)
Atrial Fibrillation
8 (.58%)
Fungal Infection
8 (.58%)
Gastrointestinal Haemorrhage
8 (.58%)
Neuropathy Peripheral
8 (.58%)
Overdose
8 (.58%)
Pancytopenia
8 (.58%)
Respiratory Arrest
8 (.58%)
Tinnitus
8 (.58%)
Cardiotoxicity
7 (.5%)
Confusional State
7 (.5%)
Cytolytic Hepatitis
7 (.5%)
Drug Toxicity
7 (.5%)
Gastrointestinal Disorder
7 (.5%)
Hypertension
7 (.5%)
Hypoacusis
7 (.5%)
Leukopenia
7 (.5%)
No Therapeutic Response
7 (.5%)
Pancreatitis
7 (.5%)
Candidiasis
6 (.43%)
Cardiac Failure Acute
6 (.43%)
Disease Progression
6 (.43%)
Epilepsy
6 (.43%)
Febrile Neutropenia
6 (.43%)
General Physical Health Deteriorati...
6 (.43%)
Guillain-barre Syndrome
6 (.43%)
Haematuria
6 (.43%)
Haemoglobin Decreased
6 (.43%)
Infection
6 (.43%)
Liver Function Test Abnormal
6 (.43%)
Loss Of Consciousness
6 (.43%)
Myalgia
6 (.43%)
Myositis
6 (.43%)
Necrotising Ulcerative Gingivostoma...
6 (.43%)
Pseudomonas Infection
6 (.43%)
Renal Failure
6 (.43%)
Arthralgia
5 (.36%)
Cardiac Failure
5 (.36%)
Cholestasis
5 (.36%)
Dizziness
5 (.36%)
Drug Intolerance
5 (.36%)
Drug Level Increased
5 (.36%)
Hypokalaemia
5 (.36%)
Intestinal Obstruction
5 (.36%)
Muscular Weakness
5 (.36%)
Myoclonus
5 (.36%)
Nausea
5 (.36%)
Neurotoxicity
5 (.36%)
Polyneuropathy
5 (.36%)
Somnolence
5 (.36%)
Zygomycosis
5 (.36%)
Aplasia
4 (.29%)
Arrhythmia Supraventricular
4 (.29%)
Aspartate Aminotransferase Increase...
4 (.29%)
Blindness
4 (.29%)
Blood Bilirubin Increased
4 (.29%)
Blood Pressure Increased
4 (.29%)
Bradyarrhythmia
4 (.29%)
Catheter Site Infection
4 (.29%)
Cytomegalovirus Infection
4 (.29%)
Disease Recurrence
4 (.29%)
Drug Level Decreased
4 (.29%)
Electrocardiogram Qt Prolonged
4 (.29%)
Grand Mal Convulsion
4 (.29%)
Hyperbilirubinaemia
4 (.29%)
Hypomagnesaemia
4 (.29%)
Leukaemia Recurrent
4 (.29%)
Memory Impairment
4 (.29%)
Metabolic Disorder
4 (.29%)

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This graph shows the top adverse events submitted to the FDA for Noxafil, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Noxafil is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Noxafil

What are the most common Noxafil adverse events reported to the FDA?

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This graph shows the top categories of adverse events submitted to the FDA for Noxafil, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Noxafil is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Common Uses of Noxafil According to Those Reporting Adverse Events

Why are people taking Noxafil, according to those reporting adverse events to the FDA?

Drug Use For Unknown Indication
86
Prophylaxis
77
Fungal Infection
55
Antifungal Prophylaxis
47
Product Used For Unknown Indication
42
Aspergillosis
41
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Hepatosplenic Candidiasis
39
Bronchopulmonary Aspergillosis
32
Zygomycosis
12
Lung Infection
10
Antifungal Treatment
9
Candidiasis
8
Infection Prophylaxis
6
Mucormycosis
6
Pneumonia Fungal
5
Transplant
4
Infection
4
Chronic Granulomatous Disease
4
Acute Myeloid Leukaemia
4
Fusarium Infection
4
Scedosporium Infection
3
Pseudomonas Infection
3
Hepatic Candidiasis
3
Pulmonary Mycosis
2
Neutropenia
2
Sinusitis Fungal
2
Meningitis Cryptococcal
2
Chronic Lymphocytic Leukaemia
2
Prophylaxis Against Transplant Reje...
2
Oral Lichen Planus
2
Haematological Malignancy
2
Histoplasmosis
2
Graft Versus Host Disease
2
Salvage Therapy
2
Lung Disorder
2
Coccidioidomycosis
2
Oesophageal Candidiasis
2
Respiratory Tract Infection Fungal
2
Hepatic Infection
1
Skin Graft
1
Respiratory Failure
1
Pancytopenia
1
Febrile Bone Marrow Aplasia
1
Drug Resistance
1
Bronchopneumonia
1
Lung Transplant
1
Sinusitis
1
Fungal Skin Infection
1
Aspergilloma
1
Pneumonia Primary Atypical
1
Lower Respiratory Tract Infection F...
1

Drug Labels

LabelLabelerEffective
NoxafilMerck Sharp & Dohme Corp.12-DEC-12

Noxafil Case Reports

What Noxafil safety concerns are being reported by doctors and researchers in the medical literature?

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About Results

This report contains aggregated drug side effects and adverse events for Noxafil. The data has been pulled from the United States Food and Drug Administration's (US FDA) Adverse Event Reporting System (AERS), a database containing more than 4,000,000 adverse event reports.

DrugCite expands your query using the Unified Medical Language System (UMLS) to include generic drugs and primary active ingredients. While the core of DrugCite's advanced drug filtering algorithm is based on the industry standard UMLS, DrugCite's proprietary filtering system also includes dozens of additional steps to reconcile malformed drug names in the FDA's data.

DrugCite only counts a drug if the submitter of the adverse event indicates that the drug is suspected to have caused the adverse event.

Depending on how the data is aggregated, different counts may occur. When someone submits an adverse event to the FDA, the submitter can attribute multiple adverse events to one or more drugs. For example, an individual taking Paxil could submit the adverse events "anxiety" and "suicidal ideation" for the same individual safety report (ISR). This means when DrugCite aggregates by adverse event, two distinct adverse events are counted in the adverse event graph; once for "anxiety" and again for "suicidal ideation". However, when DrugCite aggregates by individual safety reports irrespective of the details of the adverse events contained within the safety report, the report is only counted once.

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