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MARCUMAR

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Marcumar Adverse Events Reported to the FDA Over Time

How are Marcumar adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Marcumar, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Marcumar is flagged as the suspect drug causing the adverse event.

Most Common Marcumar Adverse Events Reported to the FDA

What are the most common Marcumar adverse events reported to the FDA?

Drug Interaction
76 (3.53%)
International Normalised Ratio Incr...
72 (3.34%)
Gastrointestinal Haemorrhage
38 (1.76%)
Prothrombin Time Prolonged
36 (1.67%)
Anaemia
32 (1.49%)
Melaena
22 (1.02%)
Prothrombin Time Shortened
21 (.98%)
Toxic Epidermal Necrolysis
21 (.98%)
Abdominal Pain
20 (.93%)
Haemoglobin Decreased
20 (.93%)
Haemorrhagic Anaemia
20 (.93%)
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Hypotension
20 (.93%)
Epistaxis
19 (.88%)
Pneumonia
19 (.88%)
Fall
18 (.84%)
Suicide Attempt
18 (.84%)
Fatigue
17 (.79%)
Pulmonary Embolism
17 (.79%)
Haematemesis
16 (.74%)
Thrombocytopenia
16 (.74%)
Aspartate Aminotransferase Increase...
15 (.7%)
Haemorrhage
15 (.7%)
Hypertension
15 (.7%)
Somnolence
15 (.7%)
Stevens-johnson Syndrome
15 (.7%)
Bradycardia
14 (.65%)
Dizziness
14 (.65%)
Muscle Haemorrhage
14 (.65%)
Renal Failure
14 (.65%)
Alanine Aminotransferase Increased
13 (.6%)
Atrial Fibrillation
13 (.6%)
Gastric Ulcer
13 (.6%)
General Physical Health Deteriorati...
13 (.6%)
Rhabdomyolysis
13 (.6%)
Coagulopathy
12 (.56%)
Haematoma
12 (.56%)
Hepatic Failure
12 (.56%)
Pruritus
12 (.56%)
Pyrexia
12 (.56%)
Renal Failure Acute
12 (.56%)
International Normalised Ratio Decr...
11 (.51%)
Transaminases Increased
11 (.51%)
Asthenia
10 (.46%)
Cardiac Failure
10 (.46%)
Cerebral Haemorrhage
10 (.46%)
Gamma-glutamyltransferase Increased
10 (.46%)
Nausea
10 (.46%)
Oedema Peripheral
10 (.46%)
Vomiting
10 (.46%)
Blister
9 (.42%)
Blood Bilirubin Increased
9 (.42%)
Coagulation Test Abnormal
9 (.42%)
Gastritis Erosive
9 (.42%)
Hepatotoxicity
9 (.42%)
Hyponatraemia
9 (.42%)
Malaise
9 (.42%)
Skin Disorder
9 (.42%)
Activated Partial Thromboplastin Ti...
8 (.37%)
Blood Pressure Decreased
8 (.37%)
Confusional State
8 (.37%)
Diarrhoea
8 (.37%)
Hepatitis
8 (.37%)
Hepatocellular Injury
8 (.37%)
Intentional Overdose
8 (.37%)
Upper Gastrointestinal Haemorrhage
8 (.37%)
Urinary Tract Infection
8 (.37%)
Blood Potassium Increased
7 (.33%)
Delirium
7 (.33%)
Drug Exposure During Pregnancy
7 (.33%)
Gastric Haemorrhage
7 (.33%)
Hiatus Hernia
7 (.33%)
Hypoglycaemia
7 (.33%)
Metabolic Acidosis
7 (.33%)
Multi-organ Failure
7 (.33%)
Oedema
7 (.33%)
Overdose
7 (.33%)
Syncope
7 (.33%)
Anuria
6 (.28%)
Blood Creatinine Increased
6 (.28%)
Cardiac Arrest
6 (.28%)
Cardiovascular Disorder
6 (.28%)
Circulatory Collapse
6 (.28%)
Colonic Polyp
6 (.28%)
Drug Ineffective
6 (.28%)
Haematocrit Decreased
6 (.28%)
Haemorrhage Intracranial
6 (.28%)
Inflammation
6 (.28%)
International Normalised Ratio Abno...
6 (.28%)
Multiple Drug Overdose Intentional
6 (.28%)
Retroperitoneal Haematoma
6 (.28%)
Retroperitoneal Haemorrhage
6 (.28%)
Sepsis
6 (.28%)
Agitation
5 (.23%)
Alopecia
5 (.23%)
Arthralgia
5 (.23%)
Autoimmune Hepatitis
5 (.23%)
Blood Alkaline Phosphatase Increase...
5 (.23%)
Blood Lactate Dehydrogenase Increas...
5 (.23%)
Blood Pressure Increased
5 (.23%)
Cardiomegaly
5 (.23%)
Death
5 (.23%)

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This graph shows the top adverse events submitted to the FDA for Marcumar, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Marcumar is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Marcumar

What are the most common Marcumar adverse events reported to the FDA?

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This graph shows the top categories of adverse events submitted to the FDA for Marcumar, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Marcumar is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Common Uses of Marcumar According to Those Reporting Adverse Events

Why are people taking Marcumar, according to those reporting adverse events to the FDA?

Atrial Fibrillation
267
Drug Use For Unknown Indication
175
Product Used For Unknown Indication
156
Thrombosis Prophylaxis
91
Pulmonary Embolism
65
Anticoagulant Therapy
62
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Thrombosis
45
Atrial Flutter
40
Deep Vein Thrombosis
29
Arrhythmia
25
Aortic Valve Replacement
18
Prophylaxis
16
Heart Valve Replacement
16
Pulmonary Arterial Hypertension
16
Coagulopathy
11
Coronary Artery Disease
10
Suicide Attempt
8
Venous Thrombosis
8
Ill-defined Disorder
8
Cerebrovascular Accident
7
Embolism Venous
7
Mitral Valve Replacement
6
Arterial Occlusive Disease
6
Pulmonary Hypertension
6
Peripheral Arterial Occlusive Disea...
4
Tachyarrhythmia
4
Antiphospholipid Syndrome
4
Cardiac Disorder
3
Embolism
3
Atrial Thrombosis
3
Rheumatoid Arthritis
3
Peripheral Vascular Disorder
2
Post Thrombotic Syndrome
2
Cardiomyopathy
2
Antiplatelet Therapy
2
Aortic Valve Incompetence
2
Platelet Aggregation
2
International Normalised Ratio
2
Maternal Drugs Affecting Foetus
2
Coronary Artery Bypass
2
Heart Valve Operation
2
Activated Protein C Resistance
2
Venous Thrombosis Limb
2
Endocarditis
2
Mitral Valve Stenosis
2
Cerebral Infarction
2
Mitral Valve Repair
2
Transient Ischaemic Attack
2
Mesenteric Vein Thrombosis
2
Varicose Vein
2
Cardiac Failure
2

Marcumar Case Reports

What Marcumar safety concerns are being reported by doctors and researchers in the medical literature?

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About Results

This report contains aggregated drug side effects and adverse events for Marcumar. The data has been pulled from the United States Food and Drug Administration's (US FDA) Adverse Event Reporting System (AERS), a database containing more than 4,000,000 adverse event reports.

DrugCite expands your query using the Unified Medical Language System (UMLS) to include generic drugs and primary active ingredients. While the core of DrugCite's advanced drug filtering algorithm is based on the industry standard UMLS, DrugCite's proprietary filtering system also includes dozens of additional steps to reconcile malformed drug names in the FDA's data.

DrugCite only counts a drug if the submitter of the adverse event indicates that the drug is suspected to have caused the adverse event.

Depending on how the data is aggregated, different counts may occur. When someone submits an adverse event to the FDA, the submitter can attribute multiple adverse events to one or more drugs. For example, an individual taking Paxil could submit the adverse events "anxiety" and "suicidal ideation" for the same individual safety report (ISR). This means when DrugCite aggregates by adverse event, two distinct adverse events are counted in the adverse event graph; once for "anxiety" and again for "suicidal ideation". However, when DrugCite aggregates by individual safety reports irrespective of the details of the adverse events contained within the safety report, the report is only counted once.

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