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Locol Adverse Events Reported to the FDA Over Time

How are Locol adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Locol, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Locol is flagged as the suspect drug causing the adverse event.

Most Common Locol Adverse Events Reported to the FDA

What are the most common Locol adverse events reported to the FDA?

Gamma-glutamyltransferase Increased
29 (2.56%)
Myalgia
23 (2.03%)
Blood Creatine Phosphokinase Increa...
21 (1.86%)
Rhabdomyolysis
20 (1.77%)
Blood Creatinine Increased
16 (1.41%)
Aspartate Aminotransferase Increase...
15 (1.33%)
Blood Alkaline Phosphatase Increase...
15 (1.33%)
Blood Lactate Dehydrogenase Increas...
14 (1.24%)
C-reactive Protein Increased
14 (1.24%)
Vomiting
14 (1.24%)
Alanine Aminotransferase Increased
13 (1.15%)
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Diarrhoea
13 (1.15%)
Drug Interaction
13 (1.15%)
Liver Function Test Abnormal
13 (1.15%)
Nausea
13 (1.15%)
Transaminases Increased
13 (1.15%)
Renal Failure Acute
12 (1.06%)
Dyspnoea
11 (.97%)
Fall
11 (.97%)
Abdominal Pain
10 (.88%)
Blood Cholesterol Increased
9 (.8%)
Haemoglobin Decreased
9 (.8%)
Low Density Lipoprotein Increased
9 (.8%)
Blood Bilirubin Increased
8 (.71%)
Coronary Artery Disease
8 (.71%)
Liver Disorder
8 (.71%)
Malaise
8 (.71%)
Muscle Spasms
8 (.71%)
Oedema Peripheral
8 (.71%)
Pruritus
8 (.71%)
Asthenia
7 (.62%)
Blood Glucose Increased
7 (.62%)
Condition Aggravated
7 (.62%)
General Physical Health Deteriorati...
7 (.62%)
Haematocrit Decreased
7 (.62%)
Hepatotoxicity
7 (.62%)
Hypoaesthesia
7 (.62%)
International Normalised Ratio Incr...
7 (.62%)
Myocardial Infarction
7 (.62%)
Angina Pectoris
6 (.53%)
Blood Urea Increased
6 (.53%)
Bradycardia
6 (.53%)
Circulatory Collapse
6 (.53%)
Hyperbilirubinaemia
6 (.53%)
Hypoglycaemia
6 (.53%)
Myoglobin Blood Increased
6 (.53%)
Syncope
6 (.53%)
Tendon Rupture
6 (.53%)
Blood Pressure Increased
5 (.44%)
Cardioactive Drug Level Increased
5 (.44%)
Diaphragmatic Paralysis
5 (.44%)
Gait Disturbance
5 (.44%)
Knee Arthroplasty
5 (.44%)
Left Ventricular Hypertrophy
5 (.44%)
Muscular Weakness
5 (.44%)
Renal Failure
5 (.44%)
White Blood Cell Count Increased
5 (.44%)
Accidental Exposure
4 (.35%)
Anaemia
4 (.35%)
Anxiety
4 (.35%)
Appendicitis
4 (.35%)
Arthralgia
4 (.35%)
Blood Creatine Phosphokinase Mb
4 (.35%)
Blood Potassium Increased
4 (.35%)
Cardiac Failure
4 (.35%)
Carpal Tunnel Syndrome
4 (.35%)
Cerebrovascular Accident
4 (.35%)
Cholestasis
4 (.35%)
Chromaturia
4 (.35%)
Drug Toxicity
4 (.35%)
Eosinophilia
4 (.35%)
Fatigue
4 (.35%)
Hepatic Cirrhosis
4 (.35%)
Hepatic Enzyme Increased
4 (.35%)
High Density Lipoprotein Increased
4 (.35%)
Hip Surgery
4 (.35%)
Hyponatraemia
4 (.35%)
Hypotension
4 (.35%)
Jaundice
4 (.35%)
Loss Of Consciousness
4 (.35%)
Macular Degeneration
4 (.35%)
Osteoarthritis
4 (.35%)
Overdose
4 (.35%)
Poor Peripheral Circulation
4 (.35%)
Pyrexia
4 (.35%)
Restlessness
4 (.35%)
Sensory Disturbance
4 (.35%)
Surgery
4 (.35%)
Abdominal Pain Lower
3 (.27%)
Abdominal Pain Upper
3 (.27%)
Aggression
3 (.27%)
Aortic Disorder
3 (.27%)
Blood Calcium Decreased
3 (.27%)
Blood Sodium Decreased
3 (.27%)
Blood Triglycerides Increased
3 (.27%)
Blood Uric Acid Increased
3 (.27%)
Bone Pain
3 (.27%)
Cardiac Failure Congestive
3 (.27%)
Chronic Obstructive Pulmonary Disea...
3 (.27%)
Colon Polypectomy
3 (.27%)
Colonic Polyp
3 (.27%)

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This graph shows the top adverse events submitted to the FDA for Locol, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Locol is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Locol

What are the most common Locol adverse events reported to the FDA?

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This graph shows the top categories of adverse events submitted to the FDA for Locol, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Locol is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Common Uses of Locol According to Those Reporting Adverse Events

Why are people taking Locol, according to those reporting adverse events to the FDA?

Hypercholesterolaemia
133
Hyperlipidaemia
43
Cardiovascular Event Prophylaxis
13
Dyslipidaemia
10
Drug Use For Unknown Indication
7
Product Used For Unknown Indication
6
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Blood Cholesterol
6
Coronary Artery Disease
6
Mixed Hyperlipidaemia
5
Low Density Lipoprotein Increased
5
Prophylaxis
5
Blood Cholesterol Increased
4
Accidental Exposure
3
Lipids Abnormal
3
Type Iia Hyperlipidaemia
2
Cerebral Infarction
2
Lipids Increased
1
Coronary Angioplasty
1
Myocardial Ischaemia
1
Lipids
1
Hyperparathyroidism
1
Nephrotic Syndrome
1

Locol Case Reports

What Locol safety concerns are being reported by doctors and researchers in the medical literature?

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About Results

This report contains aggregated drug side effects and adverse events for Locol. The data has been pulled from the United States Food and Drug Administration's (US FDA) Adverse Event Reporting System (AERS), a database containing more than 4,000,000 adverse event reports.

DrugCite expands your query using the Unified Medical Language System (UMLS) to include generic drugs and primary active ingredients. While the core of DrugCite's advanced drug filtering algorithm is based on the industry standard UMLS, DrugCite's proprietary filtering system also includes dozens of additional steps to reconcile malformed drug names in the FDA's data.

DrugCite only counts a drug if the submitter of the adverse event indicates that the drug is suspected to have caused the adverse event.

Depending on how the data is aggregated, different counts may occur. When someone submits an adverse event to the FDA, the submitter can attribute multiple adverse events to one or more drugs. For example, an individual taking Paxil could submit the adverse events "anxiety" and "suicidal ideation" for the same individual safety report (ISR). This means when DrugCite aggregates by adverse event, two distinct adverse events are counted in the adverse event graph; once for "anxiety" and again for "suicidal ideation". However, when DrugCite aggregates by individual safety reports irrespective of the details of the adverse events contained within the safety report, the report is only counted once.

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