HYDROCHLOROTHIAZIDE

Hydrochlorothiazide Adverse Events Reported to the FDA Over Time

How are Hydrochlorothiazide adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Hydrochlorothiazide, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Hydrochlorothiazide is flagged as the suspect drug causing the adverse event.

Most Common Hydrochlorothiazide Adverse Events Reported to the FDA

What are the most common Hydrochlorothiazide adverse events reported to the FDA?

Hyponatraemia	775 (2.16%)
Renal Failure Acute	734 (2.05%)
Dizziness	588 (1.64%)
Hypotension	525 (1.46%)
Hypokalaemia	427 (1.19%)
Nausea	422 (1.18%)
Dehydration	418 (1.17%)
Asthenia	399 (1.11%)
Syncope	380 (1.06%)
Vomiting	380 (1.06%)
Completed Suicide	364 (1.02%)
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Dyspnoea	354 (.99%)
Drug Interaction	353 (.98%)
Blood Pressure Increased	321 (.9%)
Fall	307 (.86%)
Diarrhoea	303 (.85%)
Angioedema	284 (.79%)
Fatigue	284 (.79%)
Drug Ineffective	279 (.78%)
Hypertension	272 (.76%)
Headache	268 (.75%)
Malaise	259 (.72%)
Cough	253 (.71%)
Renal Failure	244 (.68%)
Hyperkalaemia	236 (.66%)
Blood Creatinine Increased	234 (.65%)
Confusional State	232 (.65%)
Oedema Peripheral	222 (.62%)
Bradycardia	200 (.56%)
Loss Of Consciousness	200 (.56%)
Pruritus	168 (.47%)
Rash	166 (.46%)
Somnolence	161 (.45%)
Blood Pressure Decreased	153 (.43%)
Lactic Acidosis	153 (.43%)
Blood Potassium Decreased	152 (.42%)
Abdominal Pain	148 (.41%)
Chest Pain	146 (.41%)
Muscle Spasms	139 (.39%)
Back Pain	136 (.38%)
Weight Decreased	133 (.37%)
Blood Urea Increased	131 (.37%)
Cardiac Arrest	130 (.36%)
Blood Glucose Increased	129 (.36%)
Palpitations	129 (.36%)
Death	127 (.35%)
Pain In Extremity	122 (.34%)
Pain	121 (.34%)
Myocardial Infarction	120 (.33%)
Feeling Abnormal	119 (.33%)
Inappropriate Antidiuretic Hormone ...	118 (.33%)
Condition Aggravated	117 (.33%)
Blood Pressure Inadequately Control...	116 (.32%)
Hyperhidrosis	113 (.32%)
Insomnia	113 (.32%)
Anaemia	112 (.31%)
Cerebrovascular Accident	111 (.31%)
Decreased Appetite	108 (.3%)
Diabetes Mellitus	108 (.3%)
Arthralgia	107 (.3%)
Heart Rate Increased	106 (.3%)
Blood Sodium Decreased	105 (.29%)
Pyrexia	103 (.29%)
Orthostatic Hypotension	100 (.28%)
Hypoaesthesia	99 (.28%)
Muscular Weakness	99 (.28%)
Pneumonia	99 (.28%)
Renal Impairment	99 (.28%)
Tremor	98 (.27%)
Weight Increased	98 (.27%)
Overdose	97 (.27%)
Lethargy	94 (.26%)
General Physical Health Deteriorati...	93 (.26%)
Urinary Tract Infection	93 (.26%)
Constipation	91 (.25%)
Medication Error	90 (.25%)
Vision Blurred	90 (.25%)
Electrocardiogram Qt Prolonged	88 (.25%)
Rhabdomyolysis	88 (.25%)
Hypersensitivity	87 (.24%)
Myalgia	87 (.24%)
Atrial Fibrillation	85 (.24%)
Convulsion	84 (.23%)
Paraesthesia	83 (.23%)
Product Substitution Issue	83 (.23%)
Hypoglycaemia	82 (.23%)
Abdominal Pain Upper	81 (.23%)
Depressed Level Of Consciousness	81 (.23%)
Chest Discomfort	79 (.22%)
Dry Mouth	79 (.22%)
Haemoglobin Decreased	79 (.22%)
Pancreatitis	79 (.22%)
Respiratory Arrest	79 (.22%)
Cardio-respiratory Arrest	78 (.22%)
Drug Hypersensitivity	78 (.22%)
Gait Disturbance	78 (.22%)
Swelling Face	78 (.22%)
Disorientation	77 (.21%)
Cardiac Failure	74 (.21%)
Depression	74 (.21%)
Pancreatitis Acute	74 (.21%)

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This graph shows the top adverse events submitted to the FDA for Hydrochlorothiazide, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Hydrochlorothiazide is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Hydrochlorothiazide

What are the most common Hydrochlorothiazide adverse events reported to the FDA?

Neurological	2346 (6.54%)
Electrolyte And Fluid Balance Condi...	2131 (5.94%)
Renal Disorders	1357 (3.79%)
Gastrointestinal Signs	1352 (3.77%)
Cardiac Arrhythmias	1186 (3.31%)
Cardiac And Vascular Investigations	1155 (3.22%)
Respiratory	1141 (3.18%)
Epidermal And Dermal Conditions	1134 (3.16%)
Decreased And Nonspecific Blood Pre...	904 (2.52%)
Therapeutic And Nontherapeutic Effe...	795 (2.22%)
Infections - Pathogen Unspecified	680 (1.9%)
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Injuries	590 (1.65%)
Renal And Urinary Tract Investigati...	559 (1.56%)
Water, Electrolyte And Mineral	538 (1.5%)
Medication Errors	523 (1.46%)
Hematology Investigations	478 (1.33%)
Muscle	471 (1.31%)
Suicidal And Self-injurious Behavio...	461 (1.29%)
Gastrointestinal Motility And Defec...	454 (1.27%)
Musculoskeletal And Connective Tiss...	446 (1.24%)
Hepatic And Hepatobiliary	376 (1.05%)
Vascular Hypertensive	371 (1.03%)
Angiedema And Urticaria	363 (1.01%)
Deliria	346 (.97%)
Urinary Tract Signs	325 (.91%)
Physical Examination Topics	324 (.9%)
Coronary Artery	305 (.85%)
Glucose Metabolism Disorders	303 (.85%)
Headaches	296 (.83%)
Metabolic, Nutritional And Blood Ga...	288 (.8%)
Central Nervous System Vascular	287 (.8%)
Joint	280 (.78%)
Acid-base	271 (.76%)
Movement Disorders	260 (.73%)
Allergic Conditions	254 (.71%)
Hepatobiliary	246 (.69%)
Skin Appendage Conditions	224 (.62%)
Anxiety Disorders	223 (.62%)
Appetite And General Nutritional	223 (.62%)
Anemias Nonhemolytic And Marrow Dep...	221 (.62%)
Lower Respiratory Tract Disorders	217 (.61%)
Cardiac Disorder Signs	211 (.59%)
Chemical Injury And Poisoning	201 (.56%)
Vision	196 (.55%)
Exocrine Pancreas Conditions	188 (.52%)
Fatal Outcomes	180 (.5%)
Sleep Disorders	179 (.5%)
Myocardial	174 (.49%)
Bone And Joint Injuries	171 (.48%)
Enzyme	156 (.44%)
Heart Failures	150 (.42%)
Product Quality Issues	149 (.42%)
Mental Impairment	148 (.41%)
Oral Soft Tissue Conditions	147 (.41%)
Vascular	147 (.41%)
Body Temperature Conditions	141 (.39%)
Bone, Calcium, Magnesium And Phosph...	141 (.39%)
Psychiatric	140 (.39%)
Seizures	138 (.38%)
Bacterial Infectious	133 (.37%)
Hypothalamus And Pituitary Gland	124 (.35%)
Upper Respiratory Tract Disorders	122 (.34%)
White Blood Cell	121 (.34%)
Bronchial Disorders	118 (.33%)
Lifestyle Issues	115 (.32%)
Hematological And Lymphoid Tissue T...	114 (.32%)
Arteriosclerosis, Stenosis, Vascula...	109 (.3%)
Gastrointestinal Hemorrhages	107 (.3%)
Inner Ear And Viiith Cranial Nerve	105 (.29%)
Depressed Mood Disorders	102 (.28%)
Gastrointestinal Inflammatory Condi...	92 (.26%)
Tongue Conditions	92 (.26%)
Nephropathies	88 (.25%)
Salivary Gland Conditions	88 (.25%)
Lipid Analyses	85 (.24%)
Eye	83 (.23%)
Protein And Chemistry Analyses	78 (.22%)
Viral Infectious	75 (.21%)
Bone Disorders	74 (.21%)
Cardiac Valve	74 (.21%)
Platelet	72 (.2%)
Pulmonary Vascular	72 (.2%)
Endocrine Investigations	68 (.19%)
Gastrointestinal Ulceration And Per...	68 (.19%)
Therapeutic Procedures And Supporti...	67 (.19%)
Purine And Pyrimidine Metabolism	65 (.18%)
Disturbances In Thinking	63 (.18%)
Procedural And Device Related Injur...	63 (.18%)
Vascular Hemorrhagic	63 (.18%)
Toxicology And Therapeutic Drug Mon...	59 (.16%)
Ocular Infections, Irritations And ...	58 (.16%)
Skin Vascular Abnormalities	58 (.16%)
Changes In Physical Activity	55 (.15%)
Gastrointestinal Neoplasms Malignan...	50 (.14%)
Hemolyses And Related Conditions	50 (.14%)
Peripheral Neuropathies	49 (.14%)
Urolithiases	49 (.14%)
Gallbladder	48 (.13%)
Mood Disorders	48 (.13%)
Pleural	46 (.13%)
Psychiatric And Behavioural Symptom...	46 (.13%)

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This graph shows the top categories of adverse events submitted to the FDA for Hydrochlorothiazide, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Hydrochlorothiazide is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.