How are Estradiol adverse event reports trending over time?
This graph shows volume of adverse events submitted to the FDA by quarter for Estradiol, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Estradiol is flagged as the suspect drug causing the adverse event.
What are the most common Estradiol adverse events reported to the FDA?
Pain | 5349 (9.19%) |
Injury | 4450 (7.64%) |
Anxiety | 2309 (3.97%) |
Pulmonary Embolism | 2235 (3.84%) |
Gallbladder Disorder | 2028 (3.48%) |
Emotional Distress | 2001 (3.44%) |
Deep Vein Thrombosis | 1983 (3.41%) |
Cholecystitis Chronic | 1813 (3.11%) |
Breast Cancer Female | 1490 (2.56%) |
Cholelithiasis | 1399 (2.4%) |
General Physical Health Deteriorati... | 1034 (1.78%) |
Show More |
Share/Embed Graph Export Data
This graph shows the top adverse events submitted to the FDA for Estradiol, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Estradiol is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.
What are the most common Estradiol adverse events reported to the FDA?
Gallbladder | 6799 (11.68%) |
Injuries | 5310 (9.12%) |
Gastrointestinal Signs | 3347 (5.75%) |
Anxiety Disorders | 3075 (5.28%) |
Embolism And Thrombosis | 2829 (4.86%) |
Pulmonary Vascular | 2411 (4.14%) |
Mood Disorders | 2192 (3.77%) |
Breast Neoplasms Malignant And Unsp... | 2028 (3.48%) |
Depressed Mood Disorders | 1374 (2.36%) |
Central Nervous System Vascular | 1142 (1.96%) |
Neurological | 957 (1.64%) |
Show More |
Share/Embed Graph Export Data
This graph shows the top categories of adverse events submitted to the FDA for Estradiol, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Estradiol is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.
Why are people taking Estradiol, according to those reporting adverse events to the FDA?
Hormone Replacement Therapy | 3395 |
Contraception | 3384 |
Product Used For Unknown Indication | 1802 |
Acne | 1195 |
Premenstrual Syndrome | 754 |
Oral Contraception | 691 |
Show More |
Label | Labeler | Effective |
---|---|---|
Tri-norinyl | Watson Pharma, Inc. | 01-MAY-07 |
Femhrt | Physicians Total Care, Inc. | 02-OCT-08 |
Femcon Fe | Physicians Total Care, Inc. | 01-APR-09 |
Femcon Fe | Warner Chilcott (US), LLC | 01-APR-09 |
Ovcon 35 | Warner Chilcott (US), LLC | 01-APR-09 |
Ovcon 50 | Warner Chilcott (US), LLC | 01-APR-09 |
Angeliq | Physicians Total Care, Inc. | 29-MAY-09 |
Tilia Fe | Watson Pharma, Inc. | 01-JUN-09 |
Climara | Bayer HealthCare Pharmaceuticals Inc. | 03-JUN-09 |
Estrostep Fe | Warner Chilcott (US), LLC | 07-JUL-09 |
Divigel | Physicians Total Care, Inc. | 31-AUG-09 |
Estradiol | Heritage Pharmaceuticals Inc | 31-AUG-09 |
Estrace | Physicians Total Care, Inc. | 01-SEP-09 |
Aviane | Physicians Total Care, Inc. | 15-SEP-09 |
Estring | Pharmacia and Upjohn Company | 01-OCT-09 |
Estring | Physicians Total Care, Inc. | 01-OCT-09 |
Estradiol | Stat Rx USA | 27-OCT-09 |
Estradiol | PD-Rx Pharmaceuticals, Inc. | 09-DEC-09 |
Estradiol | Mylan Pharmaceuticals Inc. | 09-DEC-09 |
Estradiol | Mylan Pharmaceuticals Inc. | 09-DEC-09 |
Estradiol | PD-Rx Pharmaceuticals, Inc. | 09-DEC-09 |
Femtrace | Warner Chilcott (US), LLC | 17-DEC-09 |
Quasense | Watson Pharma, Inc. | 28-DEC-09 |
Estradiol | Physicians Total Care, Inc. | 18-JAN-10 |
Estradiol Valerate | Paddock Laboratories, Inc. | 27-JAN-10 |
Trivora | Watson Pharma, Inc. | 15-FEB-10 |
Depo-estradiol | Pharmacia and Upjohn Company | 02-MAR-10 |
Depo-estradiol | Physicians Total Care, Inc. | 02-MAR-10 |
Estradiol | Physicians Total Care, Inc. | 09-JUN-10 |
Seasonique | Physicians Total Care, Inc. | 01-JUL-10 |
Guna-beta-estradiol | Guna spa | 09-JUL-10 |
Gianvi | Physicians Total Care, Inc. | 11-JUL-10 |
Zenchent | Watson Pharma, Inc. | 13-AUG-10 |
Zenchent | Physicians Total Care, Inc. | 13-AUG-10 |
Evamist | Physicians Total Care, Inc. | 24-AUG-10 |
Zarah | Watson Pharma, Inc. | 09-SEP-10 |
Natazia | Physicians Total Care, Inc. | 05-OCT-10 |
Altavera | Sandoz Inc | 07-OCT-10 |
Nordette | Teva Women's Health, Inc. | 08-OCT-10 |
Lybrel | Wyeth Pharmaceuticals Company, a subsidiary of Pfizer Inc. | 12-OCT-10 |
Estradiol | KAISER FOUNDATION HOSPITALS | 29-OCT-10 |
Gianvi | MedVantx, Inc. | 03-NOV-10 |
Leena | Watson Pharma, Inc. | 12-NOV-10 |
Trinessa | Watson Pharmaceuticals | 07-DEC-10 |
Tilia Fe | Physicians Total Care, Inc. | 07-DEC-10 |
Mononessa | Watson Pharmaceuticals | 07-DEC-10 |
Necon 777 | Watson Pharma Inc | 15-DEC-10 |
Enpresse | Physicians Total Care, Inc. | 20-DEC-10 |
Levonest | Novast Laboratories, Ltd. | 12-JAN-11 |
Kariva | Physicians Total Care, Inc. | 16-JAN-11 |
Cryselle | Physicians Total Care, Inc. | 20-JAN-11 |
Apri | Physicians Total Care, Inc. | 24-JAN-11 |
Kelnor 1/35 | Physicians Total Care, Inc. | 24-JAN-11 |
Estradiol | Rebel Distributors Corp | 26-JAN-11 |
Enpresse | Rebel Distributors Corp | 26-JAN-11 |
Solia | Prasco Laboratories | 02-FEB-11 |
Ortho Tri Cyclen Lo | Physicians Total Care, Inc. | 03-FEB-11 |
Jinteli | Physicians Total Care, Inc. | 15-FEB-11 |
Ocella | Physicians Total Care, Inc. | 23-FEB-11 |
Necon | Rebel Distributors Corp | 15-MAR-11 |
Necon 1/35 | Physicians Total Care, Inc. | 15-MAR-11 |
Jevantique | Watson Pharma, Inc. | 23-MAR-11 |
Introvale | Sandoz Inc | 29-APR-11 |
Tilia Fe | Watson Pharma, Inc. | 13-MAY-11 |
Briellyn | Glenmark Generics Inc., USA | 31-MAY-11 |
Estradiol / Norethindrone Acetate | Breckenridge Pharmaceutical, Inc. | 10-JUN-11 |
Amethyst | Watson Pharma, Inc. | 14-JUN-11 |
Femhrt | Warner Chilcott (US), LLC | 21-JUN-11 |
Loseasonique | Teva Women's Health, Inc. | 30-JUN-11 |
Tilia Fe | Rebel Distributors Corp | 29-JUL-11 |
Tri-sprintec | MedVantx, Inc. | 03-AUG-11 |
Amethia | Watson Pharma, Inc. | 15-AUG-11 |
Tri-sprintec | Rebel Distributors Corp | 06-SEP-11 |
Trinessa | Rebel Distributors Corp | 13-SEP-11 |
Trivora | Physicians Total Care, Inc. | 22-SEP-11 |
Vestura | Watson Pharma, Inc. | 01-OCT-11 |
Myzilra | Qualitest Pharmaceuticals | 03-OCT-11 |
Aviane28 Day | Rebel Distributors Corp | 04-OCT-11 |
Norethindrone And Ethinyl Estradiol And Ferrous Fumarate | Lupin Pharmaceuticals, Inc. | 04-OCT-11 |
Orsythia | Qualitest Pharmaceuticals | 04-OCT-11 |
Necon 777777 | Dispensing Solutions, Inc. | 06-OCT-11 |
Gildess Fe 1.5/30 | Qualitest Pharmaceuticals | 07-OCT-11 |
Gildess Fe 1/20 | Qualitest Pharmaceuticals | 13-OCT-11 |
Estradiol Valerate | Sandoz Inc | 13-OCT-11 |
Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol | LUPIN PHARMACEUTICALS INC | 18-OCT-11 |
Cyclafem 7/7/7 | Qualitest Pharmaceuticals | 18-OCT-11 |
Cyclafem 1/35 | Qualitest Pharmaceuticals | 21-OCT-11 |
Altavera | Sandoz Inc | 16-NOV-11 |
Evamist | Ther-Rx Corporation | 09-DEC-11 |
Estradiol Transdermal System | Alvogen, Inc. | 19-DEC-11 |
Estrace | Warner Chilcott (US), LLC | 27-DEC-11 |
Loseasonique | Physicians Total Care, Inc. | 10-JAN-12 |
Estring | U.S. Pharmaceuticals | 12-JAN-12 |
Nuvaring | Physicians Total Care, Inc. | 09-FEB-12 |
Estradiol | Preferred Pharmaceuticals, Inc | 13-FEB-12 |
Delestrogen | JHP Pharmaceuticals LLC | 22-FEB-12 |
Estrasorb | Medicis Pharmaceutical Corp | 24-FEB-12 |
Ortho Tri Cyclen | Physicians Total Care, Inc. | 27-FEB-12 |
Angeliq | Bayer HealthCare Pharmaceuticals Inc. | 29-FEB-12 |
Norgestrel/ethinyl Estradiol | Akrimax Pharmaceuticals, LLC | 29-FEB-12 |
Necon 10/11 | Watson Pharma, Inc. | 07-MAR-12 |
Necon 1/35 | Watson Pharma, Inc. | 07-MAR-12 |
Necon 0.5/35 | Watson Pharma, Inc. | 07-MAR-12 |
Low-ogestrel | Watson Pharma, Inc. | 08-MAR-12 |
Ogestrel 0.5/50 | Watson Pharma, Inc. | 08-MAR-12 |
Levora | Watson Pharma, Inc. | 08-MAR-12 |
Alyacen 7/7/7 | Glenmark Generics Inc., USA | 09-MAR-12 |
Marlissa | Glenmark Generics Inc.,USA | 09-MAR-12 |
Sronyx | Watson Pharma, Inc. | 09-MAR-12 |
Alyacen 1/35 | Glenmark Generics Inc.,USA | 09-MAR-12 |
Yasmin | Physicians Total Care, Inc. | 15-MAR-12 |
Vagifem | Physicians Total Care, Inc. | 15-MAR-12 |
Estradiol | Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC | 15-MAR-12 |
Generess Fe | Watson Pharma, Inc. | 30-MAR-12 |
Estradiol Valerate | JHP Pharmaceuticals, LLC | 09-APR-12 |
Femring | Warner Chilcott (US), LLC | 10-APR-12 |
Gianvi | Teva Pharmaceuticals USA Inc | 12-APR-12 |
Zovia 1/50e-28 | Physicians Total Care, Inc. | 13-APR-12 |
Zovia 1/35e-28 | Physicians Total Care, Inc. | 13-APR-12 |
Norgestimate And Ethinyl Estradiol | Glenmark Generics Inc., USA | 13-APR-12 |
Junel Fe 1.5/30 | Physicians Total Care, Inc. | 16-APR-12 |
Junel 1.5/30 | Physicians Total Care, Inc. | 16-APR-12 |
Junel Fe 1/20 | Physicians Total Care, Inc. | 16-APR-12 |
Viorele | Glenmark Generics Inc., USA | 17-APR-12 |
Norgestimate And Ethinyl Estradiol | Glenmark Generics Inc., USA | 17-APR-12 |
Tri-sprintec | Physicians Total Care, Inc. | 19-APR-12 |
Microgestin Fe | Physicians Total Care, Inc. | 26-APR-12 |
Microgestin | Physicians Total Care, Inc. | 26-APR-12 |
Vestura | Watson Pharma, Inc. | 01-MAY-12 |
Velivettriphasic Regimen | Physicians Total Care, Inc. | 16-MAY-12 |
Trinessa | Physicians Total Care, Inc. | 23-MAY-12 |
Nuvaring | Organon Pharmaceuticals USA | 31-MAY-12 |
Nortrel 7/7/7(28 Day Regimen) | Physicians Total Care, Inc. | 01-JUN-12 |
Divigel | Upsher-Smith Laboratories, Inc. | 12-JUN-12 |
Junel Fe 1.5/30 | Rebel Distributors Corp | 13-JUN-12 |
Levora | Physicians Total Care, Inc. | 18-JUN-12 |
Syeda | Sandoz Inc | 20-JUN-12 |
Natazia | Bayer HealthCare Pharmaceuticals Inc. | 27-JUN-12 |
Yasmin | Bayer HealthCare Pharmaceuticals Inc. | 27-JUN-12 |
Gildess 1.5/30 | Qualitest Pharmaceuticals | 28-JUN-12 |
Gildess 1/20 | Qualitest Pharmaceuticals | 28-JUN-12 |
Lo Loestrin Fe | Warner Chilcott (US), LLC | 28-JUN-12 |
Safyral | Bayer HealthCare Pharmaceuticals Inc. | 28-JUN-12 |
Beyaz | Bayer HealthCare Pharmaceuticals Inc. | 28-JUN-12 |
Elestrin | Jazz Pharmaceuticals Commercial Corp. | 29-JUN-12 |
Elestrin | Jazz Pharmaceuticals Commercial Corp. | 29-JUN-12 |
Tri-lo-sprintec | Teva Pharmaceuticals USA Inc | 03-JUL-12 |
Estarylla | Sandoz Inc | 05-JUL-12 |
Tri-estarylla | Sandoz Inc | 06-JUL-12 |
Levora | Rebel Distributors Corp | 10-JUL-12 |
Estradiol | PD-Rx Pharmaceuticals, Inc. | 16-JUL-12 |
Estradiol | Watson Laboratories, Inc. | 16-JUL-12 |
Estradiol | PD-Rx Pharmaceuticals, Inc. | 16-JUL-12 |
Microgestin Fe | Watson Pharma, Inc. | 19-JUL-12 |
Microgestin | Watson Pharma, Inc. | 19-JUL-12 |
Zovia 1/35e-28 | Watson Pharma, Inc. | 19-JUL-12 |
Zovia 1/50e-28 | Watson Pharma, Inc. | 19-JUL-12 |
Mimvey | Teva Pharmaceuticals USA Inc | 20-JUL-12 |
Seasonique | Teva Women's Health | 23-JUL-12 |
Philith | Northstar Rx LLC | 01-AUG-12 |
Mono-linyah | Northstar Rx LLC | 01-AUG-12 |
Nortrel(28 Day Regimen) | Barr Laboratories Inc. | 03-AUG-12 |
Nortrel(21 Day Regimen) | Barr Laboratories Inc. | 03-AUG-12 |
Apri | Barr Laboratories Inc. | 06-AUG-12 |
Nortrel 7/7/7(28 Day Regimen) | Barr Laboratories Inc. | 07-AUG-12 |
Tri-sprintec | Barr Laboratories Inc. | 07-AUG-12 |
Zeosa | Teva Pharmaceuticals USA Inc | 13-AUG-12 |
Cyclessa | Organon Pharmaceuticals USA | 16-AUG-12 |
Aranelle | Barr Laboratories Inc. | 16-AUG-12 |
Cryselle | Barr Laboratories Inc. | 16-AUG-12 |
Emoquette | Qualitest Pharmaceuticals | 16-AUG-12 |
Tri-legest Fe28 Day | Barr Laboratories Inc. | 17-AUG-12 |
Velivettriphasic Regimen | Barr Laboratories Inc. | 17-AUG-12 |
Lessina | Barr Laboratories Inc. | 21-AUG-12 |
Estradiol | Barr Laboratories Inc. | 21-AUG-12 |
Portia | Barr Laboratories Inc. | 23-AUG-12 |
Previfem | Qualitest Pharmaceuticals | 24-AUG-12 |
Tri Previfem | Qualitest Pharmaceuticals | 24-AUG-12 |
Balziva | Barr Laboratories Inc. | 27-AUG-12 |
Enpresse | Barr Laboratories Inc. | 28-AUG-12 |
Estradiol / Norethindrone Acetate | Physicians Total Care, Inc. | 29-AUG-12 |
Levonest | Northstar Rx LLC | 01-SEP-12 |
Dasetta 1/35 | Northstar Rx LLC | 01-SEP-12 |
Falmina | Northstar Rx LLC | 01-SEP-12 |
Tri-linyah | Northstar Rx LLC | 01-SEP-12 |
Elinest | Northstar Rx LLC | 01-SEP-12 |
Wera | Northstar Rx LLC | 01-SEP-12 |
Estradiol | STAT Rx USA LLC | 04-SEP-12 |
Necon 0.5/35 | Rebel Distributors Corp | 05-SEP-12 |
Camreselo | Teva Pharmaceuticals USA Inc | 07-SEP-12 |
Aviane28 Day | Barr Laboratories Inc. | 07-SEP-12 |
Kariva | Barr Laboratories Inc. | 11-SEP-12 |
Junel Fe 1/20 | Barr Laboratories Inc. | 13-SEP-12 |
Junel Fe 1.5/30 | Barr Laboratories Inc. | 13-SEP-12 |
Junel 1/20 | Barr Laboratories Inc. | 13-SEP-12 |
Junel 1.5/30 | Barr Laboratories Inc. | 13-SEP-12 |
Kelnor 1/35 | Barr Laboratories Inc. | 14-SEP-12 |
Estradiol | KAISER FOUNDATION HOSPITALS | 19-SEP-12 |
Loryna | Sandoz Inc | 25-SEP-12 |
Dasetta 7/7/7 | Northstar Rx LLC | 01-OCT-12 |
Seasonale | Duramed Pharmaceuticals, Inc. | 05-OCT-12 |
Jolessa | Barr Laboratories Inc. | 11-OCT-12 |
Kurvelo | Lupin Pharmaceuticals, Inc. | 17-OCT-12 |
Ortho Evra | Janssen Pharmaceutical, Inc. | 23-OCT-12 |
Levonorgestrel And Ethinyl Estradiol | Lupin Pharmaceuticals, Inc. | 24-OCT-12 |
Estradiol | Mylan Pharmaceuticals Inc. | 29-OCT-12 |
Mircette | Teva Women's Health, Inc. | 14-NOV-12 |
Estradiol | Cardinal Health | 16-NOV-12 |
Gildagia | Qualitest Pharmaceuticals | 27-NOV-12 |
Loestrin Fe 1.5/3028 Day | Teva Women's Health, Inc | 03-DEC-12 |
Loestrin 1/2021 Day | Teva Women's Health, Inc | 03-DEC-12 |
Loestrin Fe 1/2028 Day | Teva Women's Health, Inc | 03-DEC-12 |
Loestrin 1.5/3021 Day | Teva Women's Health, Inc | 03-DEC-12 |
Reclipsen | Watson Pharma, Inc. | 10-DEC-12 |
Jinteli | Teva Pharmaceuticals USA Inc | 17-DEC-12 |
Wymzya Fe | Lupin Pharmaceuticals, Inc. | 19-DEC-12 |
Prefest | Teva Women's Health, Inc. | 20-DEC-12 |
Drospirenone And Ethinyl Estradiol | Lupin Pharmaceuticals, Inc. | 03-JAN-13 |
Alora | Watson Pharma, Inc. | 03-JAN-13 |
Minivelle | Noven Therapeutics, LLC | 03-JAN-13 |
Estrace | Warner Chilcott (US), LLC | 09-JAN-13 |
Estrogel | ASCEND Therapeutics, Inc. | 10-JAN-13 |
Chateal | Afaxys Inc. | 16-JAN-13 |
Estradiol | Bryant Ranch Prepack | 17-JAN-13 |
Estradiol | Bryant Ranch Prepack | 18-JAN-13 |
Estradiol | Bryant Ranch Prepack | 18-JAN-13 |
Levonorgestrel And Ethinyl Estradiol | Lupin Pharmaceuticals, Inc. | 25-JAN-13 |
Ocella | BARR LABORATORIES, INC. | 07-FEB-13 |
Camrese | TEVA Pharmaceuticals USA Inc | 21-FEB-13 |
Ortho Cept | Janssen Pharmaceuticals, Inc. | 27-FEB-13 |
Ortho Tri Cyclen Lo | Janssen Pharmaceuticals, Inc. | 04-MAR-13 |
Ortho Tri Cyclen | Janssen Pharmaceuticals, Inc. | 08-MAR-13 |
Ortho Cyclen | Janssen Pharmaceuticals, Inc. | 08-MAR-13 |
Levonorgestrel And Ethinyl Estradiol | Mylan Pharmaceuticals Inc. | 20-MAR-13 |
Ortho-novum 777 | Janssen Pharmaceuticals, Inc. | 29-MAR-13 |
Modicon | Janssen Pharmaceuticals, Inc. | 29-MAR-13 |
Ortho Novum 135 | Janssen Pharmaceuticals, Inc. | 29-MAR-13 |
Norinyl | Watson Pharma, Inc. | 03-APR-13 |
Brevicon | Watson Pharma, Inc. | 03-APR-13 |
Estradiol Valerate | JHP Pharmaceuticals, LLC | 04-APR-13 |
Vagifem | Novo Nordisk | 11-APR-13 |
Nortrel 7/7/7(28 Day Regimen) | Barr Laboratories Inc. | 22-APR-13 |
Orsythia | Qualitest Pharmaceuticals | 26-APR-13 |
What Estradiol safety concerns are being reported by doctors and researchers in the medical literature?
This report contains aggregated drug side effects and adverse events for Estradiol. The data has been pulled from the United States Food and Drug Administration's (US FDA) Adverse Event Reporting System (AERS), a database containing more than 4,000,000 adverse event reports.
DrugCite expands your query using the Unified Medical Language System (UMLS) to include generic drugs and primary active ingredients. While the core of DrugCite's advanced drug filtering algorithm is based on the industry standard UMLS, DrugCite's proprietary filtering system also includes dozens of additional steps to reconcile malformed drug names in the FDA's data.
DrugCite only counts a drug if the submitter of the adverse event indicates that the drug is suspected to have caused the adverse event.
Depending on how the data is aggregated, different counts may occur. When someone submits an adverse event to the FDA, the submitter can attribute multiple adverse events to one or more drugs. For example, an individual taking Paxil could submit the adverse events "anxiety" and "suicidal ideation" for the same individual safety report (ISR). This means when DrugCite aggregates by adverse event, two distinct adverse events are counted in the adverse event graph; once for "anxiety" and again for "suicidal ideation". However, when DrugCite aggregates by individual safety reports irrespective of the details of the adverse events contained within the safety report, the report is only counted once.
Share your experience with Estradiol.