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DOXYCYCLINE

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Doxycycline Adverse Events Reported to the FDA Over Time

How are Doxycycline adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Doxycycline, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Doxycycline is flagged as the suspect drug causing the adverse event.

Most Common Doxycycline Adverse Events Reported to the FDA

What are the most common Doxycycline adverse events reported to the FDA?

Nausea
174 (1.71%)
Vomiting
167 (1.64%)
Rash
150 (1.48%)
Headache
142 (1.4%)
Diarrhoea
125 (1.23%)
Drug Interaction
114 (1.12%)
Dyspnoea
111 (1.09%)
Drug Hypersensitivity
107 (1.05%)
Drug Ineffective
104 (1.02%)
Pyrexia
93 (.92%)
Asthenia
89 (.88%)
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Pain
86 (.85%)
Malaise
84 (.83%)
Dizziness
80 (.79%)
Pruritus
80 (.79%)
Chest Pain
79 (.78%)
Hypersensitivity
71 (.7%)
Stevens-johnson Syndrome
68 (.67%)
Oesophageal Ulcer
66 (.65%)
Fatigue
63 (.62%)
Erythema
60 (.59%)
Paraesthesia
60 (.59%)
Drug Rash With Eosinophilia And Sys...
57 (.56%)
Abdominal Pain Upper
56 (.55%)
Renal Failure Acute
56 (.55%)
Photosensitivity Reaction
55 (.54%)
Urticaria
55 (.54%)
Dysphagia
54 (.53%)
Confusional State
53 (.52%)
Renal Failure
52 (.51%)
Arthralgia
51 (.5%)
Hypotension
51 (.5%)
Oedema Peripheral
50 (.49%)
Benign Intracranial Hypertension
48 (.47%)
Abdominal Pain
47 (.46%)
Condition Aggravated
47 (.46%)
Depression
46 (.45%)
Abdominal Discomfort
44 (.43%)
Hypoglycaemia
44 (.43%)
Convulsion
43 (.42%)
Drug Exposure During Pregnancy
41 (.4%)
Hypoaesthesia
41 (.4%)
Liver Function Test Abnormal
41 (.4%)
Cholestasis
40 (.39%)
Dyspepsia
39 (.38%)
Vision Blurred
39 (.38%)
Cough
38 (.37%)
Feeling Abnormal
38 (.37%)
Weight Decreased
38 (.37%)
Alanine Aminotransferase Increased
37 (.36%)
Blister
37 (.36%)
Burning Sensation
36 (.35%)
Muscle Spasms
36 (.35%)
Swollen Tongue
35 (.34%)
Tinnitus
35 (.34%)
Myalgia
34 (.33%)
Anxiety
33 (.32%)
Aspartate Aminotransferase Increase...
33 (.32%)
Dehydration
33 (.32%)
Intracranial Pressure Increased
33 (.32%)
Pancreatitis
33 (.32%)
Toxic Epidermal Necrolysis
33 (.32%)
Visual Impairment
32 (.32%)
Chills
31 (.31%)
Gastrooesophageal Reflux Disease
31 (.31%)
Oesophagitis
31 (.31%)
Respiratory Failure
31 (.31%)
Pneumonia
30 (.3%)
Renal Impairment
30 (.3%)
Dysgeusia
29 (.29%)
Jaundice
29 (.29%)
Decreased Appetite
28 (.28%)
Haemoglobin Decreased
27 (.27%)
Hepatitis
27 (.27%)
Liver Disorder
27 (.27%)
Pancreatitis Acute
27 (.27%)
Somnolence
27 (.27%)
Tremor
27 (.27%)
Disseminated Intravascular Coagulat...
26 (.26%)
Oropharyngeal Pain
26 (.26%)
Palpitations
26 (.26%)
Angioedema
25 (.25%)
Interstitial Lung Disease
25 (.25%)
Pain In Extremity
25 (.25%)
Swelling Face
25 (.25%)
Burn Oesophageal
24 (.24%)
Gamma-glutamyltransferase Increased
24 (.24%)
Candidiasis
23 (.23%)
Fall
23 (.23%)
General Physical Health Deteriorati...
23 (.23%)
Alopecia
22 (.22%)
Amnesia
22 (.22%)
Anaemia
22 (.22%)
Insomnia
22 (.22%)
Jarisch-herxheimer Reaction
22 (.22%)
Drug Intolerance
21 (.21%)
Hyperhidrosis
21 (.21%)
Medication Error
21 (.21%)
Rash Erythematous
21 (.21%)
Rash Generalised
21 (.21%)
Septic Shock
21 (.21%)

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This graph shows the top adverse events submitted to the FDA for Doxycycline, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Doxycycline is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Doxycycline

What are the most common Doxycycline adverse events reported to the FDA?

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This graph shows the top categories of adverse events submitted to the FDA for Doxycycline, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Doxycycline is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Common Uses of Doxycycline According to Those Reporting Adverse Events

Why are people taking Doxycycline, according to those reporting adverse events to the FDA?

Acne
546
Product Used For Unknown Indication
370
Drug Use For Unknown Indication
257
Infection
149
Rosacea
148
Lyme Disease
126
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Lower Respiratory Tract Infection
107
Sinusitis
95
Malaria Prophylaxis
81
Rash
69
Bronchitis
68
Prophylaxis
67
Pneumonia
61
Respiratory Tract Infection
50
Upper Respiratory Tract Infection
48
Urinary Tract Infection
47
Antibiotic Therapy
44
Staphylococcal Infection
41
Periodontal Disease
37
Cellulitis
36
Ill-defined Disorder
34
Periodontitis
28
Cough
27
Infection Prophylaxis
25
Vaginal Infection
24
Chlamydial Infection
23
Scrub Typhus
23
Bacterial Infection
22
Brucellosis
21
Arthropod Bite
21
Dermatitis
20
Pelvic Inflammatory Disease
19
Prostatitis
19
Sclerotherapy
18
Skin Infection
18
Chronic Obstructive Pulmonary Disea...
17
Tooth Infection
16
Non-small Cell Lung Cancer
16
Syphilis
15
Tenosynovitis
15
Antibiotic Prophylaxis
15
Sepsis
15
Pyrexia
14
Rheumatoid Arthritis
14
Device Related Infection
13
Ear Infection
13
Borrelia Infection
13
Endometriosis
13
Acne Cystic
12
Lung Infection
12
Eye Infection
11

Drug Labels

LabelLabelerEffective
Doxycycline HyclateBryant Ranch Prepack07-NOV-84
DoxycyclineMylan Pharmaceuticals Inc.07-MAR-07
DoxycyclineRebel Distributors Corp.01-JUN-09
Doxycycline Hyclate CapsulesHikma Pharmaceutical01-SEP-09
Doxycycline HyclateApace Packaging LLC23-OCT-09
Doxycycline HyclateContract Pharmacy Services-PA10-MAR-10
DoxycyclineBedford Laboratories17-MAR-10
Doxycycline HyclatePhysicians Total Care, Inc.29-APR-10
Doxycycline HyclateState of Florida DOH Central Pharmacy25-MAY-10
Doxycycline HyclateState of Florida DOH Central Pharmacy27-MAY-10
Doxycycline HyclateState of Florida DOH Central Pharmacy27-MAY-10
DoxycyclineBlu Pharmaceuticals, LLC28-JUN-10
Doxycycline HyclateRebel Distributors Corp24-SEP-10
Doxycycline HyclateLarken Laboratories, Inc.15-NOV-10
Doxycycline HyclateBlenheim Pharmacal, Inc.18-NOV-10
DoxycyclineCardinal Health03-DEC-10
Doxycycline HyclatePD-Rx Pharmaceuticals, Inc.07-DEC-10
Doxycycline HyclateCardinal Health04-JAN-11
DoxycyclineKeltman Pharmaceuticals Inc.12-JAN-11
MorgidoxMedimetriks Pharmaceuticals, Inc.17-FEB-11
Doxycycline HyclateGlobal Pharmaceuticals, Division of Impax Laboratories Inc.01-APR-11
Doxycycline HyclateLegacy Pharmaceutical Packaging05-APR-11
Doxycycline MonohydrateirGlobal Pharmaceuticals, Division of Impax Laboratories Inc.22-APR-11
DoxycyclineGeneral Injectables & Vaccines, Inc25-APR-11
DoxycyclineLegacy Pharmaceutical Packaging03-MAY-11
DoxycyclineRanbaxy Pharmaceuticals Inc.19-MAY-11
Vibramycin MonohydratePfizer Laboratories Div Pfizer Inc25-MAY-11
Vibra-tabsPfizer Laboratories Div Pfizer Inc25-MAY-11
Vibramycin CalciumPfizer Laboratories Div Pfizer Inc25-MAY-11
Vibramycin HyclatePfizer Laboratories Div Pfizer Inc25-MAY-11
Doxycycline HyclatePreferred Pharmaceuticals, Inc09-JUN-11
Doxycycline HyclateApothecary Shop Wholesale Inc.21-JUN-11
DoxycyclineWest-ward Pharmaceutical Corp22-JUL-11
DoxycyclinePD-Rx Pharmaceuticals, Inc.22-JUL-11
Doxycycline HyclateAphena Pharma Solutions (Formerly TestPak)09-AUG-11
Doxycycline HyclateSafecor Health, LLC07-SEP-11
DoryxWarner Chilcott (US), LLC16-SEP-11
DoxycyclineEon Labs, Inc.24-OCT-11
DoxycyclineLake Erie Medical & Surgical Supply DBA Quality Care Products LLC09-DEC-11
Doxycycline HyclateH.J. Harkins Company, Inc.15-DEC-11
Doxycyclate HyclateGolden State Medical Supply, Inc.02-JAN-12
DoxycyclineGolden State Medical Supply, Inc.02-JAN-12
DoxycyclineHeritage Pharmaceuticals Inc.05-JAN-12
Doxycycline HyclateREMEDYREPACK INC. 12-JAN-12
DoxycyclineRanbaxy Pharmaceuticals Inc.16-JAN-12
Doxycyclate HyclateWest-ward Pharmaceutical Corp17-JAN-12
Doxycycline HyclateHHS/Program Support Center/Supply Service Center20-JAN-12
Doxycycline HyclateHHS/Program Support Center/Supply Service Center20-JAN-12
Doxycycline HyclateMutual Pharmaceutical Company, Inc.23-JAN-12
MonodoxAqua Pharmaceuticals, LLC27-JAN-12
Doxycycline MonohydrateWatson Laboratories, Inc.31-JAN-12
DoxycyclineLake Erie Medical & Surgical Supply DBA Quality Care Products LLC06-FEB-12
Doxycycline MonohydratePhysicians Total Care, Inc.07-FEB-12
Doxycycline HyclateLife Line Home Care Services, Inc.08-FEB-12
Doxycycline HyclateRebel Distributors Corp09-FEB-12
Doxy 100General Injectables & Vaccines, Inc22-FEB-12
Doxycycline Par Pharmaceutical Inc05-MAR-12
Doxycycline HyclateHHS/Program Support Center/Supply Service Center09-MAR-12
Doxycycline HyclateREMEDYREPACK INC. 29-MAR-12
Doxycycline HyclatePD-Rx Pharmaceuticals, Inc.29-MAR-12
Doxycycline HyclatePD-Rx Pharmaceuticals, Inc.29-MAR-12
Doxycycline HyclateWest-ward Pharmaceutical Corp29-MAR-12
Doxycycline HyclatePhysicians Total Care, Inc.03-APR-12
Doxycycline HyclateLannett Company, Inc.04-MAY-12
DoxycyclineMylan Pharmaceuticals Inc.08-MAY-12
DoxycyclineLannett Company, Inc.10-MAY-12
Doxycycline HyclateWatson Laboratories, Inc.01-JUN-12
Doxycycline Par Pharmaceutical Inc.04-JUN-12
Doxycycline HyclateCorePharma, LLC28-JUN-12
DoxycyclineAmerican Health Packaging13-JUL-12
Doxycycline HyclateVersaPharm Incorporated08-AUG-12
Doxy 100APP Pharmaceuticals, LLC28-AUG-12
Doxycycline HyclateIVAX Pharmaceuticals, Inc.04-SEP-12
Doxycycline Hyclate STAT Rx USA LLC05-SEP-12
Doxycycline HyclateAidarex Pharmaceuticals LLC19-SEP-12
Doxycycline HyclateAidarex Pharmaceuticals LLC19-SEP-12
Doxycycline HyclateAidarex Pharmaceuticals LLC19-SEP-12
Doxycycline Hyclate REMEDYREPACK INC. 01-OCT-12
Doxycycline HyclateDispensing Solutions, Inc.03-OCT-12
Doxycycline HyclateLiberty Pharmaceuticals, Inc.23-OCT-12
DoxycyclineLiberty Pharmaceuticals, Inc.23-OCT-12
DoxycyclinePfizer Laboratories Div Pfizer Inc02-NOV-12
OraceaGalderma Laboratories, L.P.12-NOV-12
DoxycyclineCardinal Health14-NOV-12
Doxycycline HyclateLake Erie Medical DBA Quality Care Products LLC30-NOV-12
Doxycycline HyclateMutual Pharmaceutical Company, Inc.06-DEC-12
Doxycycline HyclateIVAX Pharmaceuticals, Inc.13-DEC-12
Doxycycline HyclateMylan Pharmaceuticals Inc.18-DEC-12
Doxycycline HyclateREMEDYREPACK INC. 09-FEB-13
DoxycyclineMajor Pharmaceuticals24-FEB-13
Doxycycline HyclateMajor Pharmaceuticals24-FEB-13
Doxycycline HyclateMylan Pharmaceuticals Inc.25-FEB-13
Doxycycline HyclateREMEDYREPACK INC. 27-FEB-13
Doxycycline HyclateMajor Pharmaceuticals28-FEB-13
DoxycyclineKAISER FOUNDATION HOSPITALS15-MAR-13
Doxycycline HyclateREMEDYREPACK INC. 03-APR-13
DoxycyclineCardinal Health18-APR-13

Doxycycline Case Reports

What Doxycycline safety concerns are being reported by doctors and researchers in the medical literature?

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About Results

This report contains aggregated drug side effects and adverse events for Doxycycline. The data has been pulled from the United States Food and Drug Administration's (US FDA) Adverse Event Reporting System (AERS), a database containing more than 4,000,000 adverse event reports.

DrugCite expands your query using the Unified Medical Language System (UMLS) to include generic drugs and primary active ingredients. While the core of DrugCite's advanced drug filtering algorithm is based on the industry standard UMLS, DrugCite's proprietary filtering system also includes dozens of additional steps to reconcile malformed drug names in the FDA's data.

DrugCite only counts a drug if the submitter of the adverse event indicates that the drug is suspected to have caused the adverse event.

Depending on how the data is aggregated, different counts may occur. When someone submits an adverse event to the FDA, the submitter can attribute multiple adverse events to one or more drugs. For example, an individual taking Paxil could submit the adverse events "anxiety" and "suicidal ideation" for the same individual safety report (ISR). This means when DrugCite aggregates by adverse event, two distinct adverse events are counted in the adverse event graph; once for "anxiety" and again for "suicidal ideation". However, when DrugCite aggregates by individual safety reports irrespective of the details of the adverse events contained within the safety report, the report is only counted once.

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