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CYTOXAN

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Cytoxan Adverse Events Reported to the FDA Over Time

How are Cytoxan adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Cytoxan, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Cytoxan is flagged as the suspect drug causing the adverse event.

Most Common Cytoxan Adverse Events Reported to the FDA

What are the most common Cytoxan adverse events reported to the FDA?

Febrile Neutropenia
165 (2.58%)
Pyrexia
156 (2.44%)
Neutropenia
127 (1.99%)
Nausea
124 (1.94%)
Dehydration
110 (1.72%)
Vomiting
109 (1.71%)
Dyspnoea
106 (1.66%)
Diarrhoea
95 (1.49%)
Sepsis
74 (1.16%)
Pancytopenia
70 (1.1%)
Pneumonia
68 (1.07%)
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Hypotension
64 (1%)
Anaemia
58 (.91%)
Asthenia
54 (.85%)
Renal Failure
53 (.83%)
Abdominal Pain
49 (.77%)
Fatigue
49 (.77%)
Platelet Count Decreased
49 (.77%)
Death
47 (.74%)
Respiratory Failure
46 (.72%)
White Blood Cell Count Decreased
44 (.69%)
Hypoxia
43 (.67%)
Renal Failure Acute
43 (.67%)
Thrombocytopenia
43 (.67%)
Chest Pain
40 (.63%)
Pleural Effusion
38 (.6%)
Neuropathy Peripheral
37 (.58%)
Chills
36 (.56%)
Haemoglobin Decreased
35 (.55%)
Multi-organ Failure
35 (.55%)
Tachycardia
34 (.53%)
Cardiac Failure Congestive
33 (.52%)
Disease Progression
33 (.52%)
Headache
32 (.5%)
Pain
31 (.49%)
Cough
30 (.47%)
Rash
30 (.47%)
Mental Status Changes
29 (.45%)
Atrial Fibrillation
28 (.44%)
Lung Infiltration
27 (.42%)
Pneumonitis
27 (.42%)
Back Pain
25 (.39%)
Confusional State
24 (.38%)
Hypokalaemia
24 (.38%)
Oedema Peripheral
24 (.38%)
Mucosal Inflammation
23 (.36%)
Pain In Extremity
23 (.36%)
Pulmonary Embolism
23 (.36%)
Fall
22 (.34%)
Gastrointestinal Haemorrhage
22 (.34%)
Malaise
22 (.34%)
Acute Respiratory Distress Syndrome
21 (.33%)
Arthralgia
21 (.33%)
Cerebrovascular Accident
21 (.33%)
Infection
21 (.33%)
Septic Shock
21 (.33%)
Syncope
21 (.33%)
Body Temperature Increased
20 (.31%)
Condition Aggravated
20 (.31%)
Neutrophil Count Decreased
20 (.31%)
Pericardial Effusion
20 (.31%)
Progressive Multifocal Leukoencepha...
20 (.31%)
Alopecia
19 (.3%)
Dizziness
19 (.3%)
Drug Ineffective
18 (.28%)
Hypoaesthesia
18 (.28%)
Malignant Neoplasm Progression
18 (.28%)
Aspartate Aminotransferase Increase...
17 (.27%)
Decreased Appetite
17 (.27%)
Deep Vein Thrombosis
17 (.27%)
Hypersensitivity
17 (.27%)
Palmar-plantar Erythrodysaesthesia ...
17 (.27%)
Tumour Lysis Syndrome
17 (.27%)
Anorexia
16 (.25%)
Intestinal Perforation
16 (.25%)
Urinary Tract Infection
16 (.25%)
Weight Decreased
16 (.25%)
Blood Glucose Increased
15 (.23%)
Blood Potassium Decreased
15 (.23%)
Colitis
15 (.23%)
Oedema
15 (.23%)
Respiratory Disorder
15 (.23%)
Stem Cell Transplant
15 (.23%)
Atelectasis
14 (.22%)
Cardiac Arrest
14 (.22%)
Cellulitis
14 (.22%)
Haematocrit Decreased
14 (.22%)
Hemiparesis
14 (.22%)
Interstitial Lung Disease
14 (.22%)
White Blood Cell Count Increased
14 (.22%)
Bradycardia
13 (.2%)
Cardiomyopathy
13 (.2%)
Graft Versus Host Disease
13 (.2%)
Hepatic Enzyme Increased
13 (.2%)
Hypertension
13 (.2%)
Sinus Tachycardia
13 (.2%)
Sinusitis
13 (.2%)
Stomatitis
13 (.2%)
Supraventricular Tachycardia
13 (.2%)
Anxiety
12 (.19%)
Aphasia
12 (.19%)

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This graph shows the top adverse events submitted to the FDA for Cytoxan, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Cytoxan is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Cytoxan

What are the most common Cytoxan adverse events reported to the FDA?

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This graph shows the top categories of adverse events submitted to the FDA for Cytoxan, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Cytoxan is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Common Uses of Cytoxan According to Those Reporting Adverse Events

Why are people taking Cytoxan, according to those reporting adverse events to the FDA?

Breast Cancer
556
Multiple Myeloma
139
Chronic Lymphocytic Leukaemia
101
Drug Use For Unknown Indication
86
Non-hodgkins Lymphoma
77
Chemotherapy
52
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Multiple Sclerosis
52
Breast Cancer Metastatic
50
Systemic Lupus Erythematosus
48
Diffuse Large B-cell Lymphoma
38
B-cell Lymphoma
37
Product Used For Unknown Indication
34
Lymphoma
29
Acute Lymphocytic Leukaemia
18
Hodgkins Disease
17
Amyloidosis
16
Prostate Cancer
15
Stem Cell Transplant
15
Ovarian Cancer
12
Breast Cancer Stage Ii
11
Acute Myeloid Leukaemia
11
Neoplasm Malignant
11
Leukaemia
10
Immunosuppression
10
Mantle Cell Lymphoma
9
Rheumatoid Vasculitis
8
Renal Cell Carcinoma
7
T-cell Lymphoma
7
Polyarteritis Nodosa
7
Bone Marrow Transplant
7
Breast Cancer Stage I
7
Vasculitis
7
Carcinoma
6
Bone Marrow Conditioning Regimen
6
Haematopoietic Stem Cell Mobilisati...
6
Renal Failure
6
Behcets Syndrome
5
Scleroderma
5
Rhabdomyosarcoma
5
Inflammatory Carcinoma Of The Breas...
5
Chronic Myeloid Leukaemia
5
Wegeners Granulomatosis
5
Colorectal Cancer
4
Systemic Sclerosis
4
Ependymoma
4
Lupus Nephritis
4
Lung Disorder
4
Waldenstroms Macroglobulinaemia
4
Large Granular Lymphocytosis
3
Breast Cancer Female
3
Sarcoma
3

Cytoxan Case Reports

What Cytoxan safety concerns are being reported by doctors and researchers in the medical literature?

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About Results

This report contains aggregated drug side effects and adverse events for Cytoxan. The data has been pulled from the United States Food and Drug Administration's (US FDA) Adverse Event Reporting System (AERS), a database containing more than 4,000,000 adverse event reports.

DrugCite expands your query using the Unified Medical Language System (UMLS) to include generic drugs and primary active ingredients. While the core of DrugCite's advanced drug filtering algorithm is based on the industry standard UMLS, DrugCite's proprietary filtering system also includes dozens of additional steps to reconcile malformed drug names in the FDA's data.

DrugCite only counts a drug if the submitter of the adverse event indicates that the drug is suspected to have caused the adverse event.

Depending on how the data is aggregated, different counts may occur. When someone submits an adverse event to the FDA, the submitter can attribute multiple adverse events to one or more drugs. For example, an individual taking Paxil could submit the adverse events "anxiety" and "suicidal ideation" for the same individual safety report (ISR). This means when DrugCite aggregates by adverse event, two distinct adverse events are counted in the adverse event graph; once for "anxiety" and again for "suicidal ideation". However, when DrugCite aggregates by individual safety reports irrespective of the details of the adverse events contained within the safety report, the report is only counted once.

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