CLONIDINE

Clonidine Adverse Events Reported to the FDA Over Time

How are Clonidine adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Clonidine, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Clonidine is flagged as the suspect drug causing the adverse event.

Most Common Clonidine Adverse Events Reported to the FDA

What are the most common Clonidine adverse events reported to the FDA?

Blood Pressure Increased	676 (3.93%)
Drug Ineffective	513 (2.98%)
Hypertension	397 (2.31%)
Completed Suicide	369 (2.14%)
Hypotension	340 (1.97%)
Application Site Pruritus	325 (1.89%)
Application Site Erythema	310 (1.8%)
Dizziness	256 (1.49%)
Headache	252 (1.46%)
Somnolence	248 (1.44%)
Blood Pressure Inadequately Control...	238 (1.38%)
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Application Site Rash	230 (1.34%)
Bradycardia	156 (.91%)
Overdose	153 (.89%)
Fatigue	145 (.84%)
Dry Mouth	138 (.8%)
Dyspnoea	132 (.77%)
Death	130 (.76%)
Application Site Irritation	126 (.73%)
Nausea	125 (.73%)
Asthenia	116 (.67%)
Cardiac Arrest	115 (.67%)
Vomiting	113 (.66%)
Rash	108 (.63%)
Blood Pressure Decreased	105 (.61%)
Medication Error	103 (.6%)
Blood Pressure Fluctuation	101 (.59%)
Pruritus	101 (.59%)
Fall	98 (.57%)
Respiratory Arrest	97 (.56%)
Drug Effect Decreased	96 (.56%)
Chest Pain	95 (.55%)
Application Site Vesicles	94 (.55%)
Poisoning	94 (.55%)
Drug Interaction	91 (.53%)
Feeling Abnormal	89 (.52%)
Product Substitution Issue	88 (.51%)
Lethargy	84 (.49%)
Loss Of Consciousness	83 (.48%)
Multiple Drug Overdose	83 (.48%)
Constipation	81 (.47%)
Syncope	81 (.47%)
Pain	80 (.46%)
Confusional State	79 (.46%)
Suicide Attempt	77 (.45%)
Drug Toxicity	76 (.44%)
Heart Rate Increased	76 (.44%)
Heart Rate Decreased	73 (.42%)
Anxiety	72 (.42%)
Malaise	72 (.42%)
Agitation	70 (.41%)
Convulsion	70 (.41%)
Insomnia	67 (.39%)
Product Quality Issue	67 (.39%)
Hyperhidrosis	64 (.37%)
Diarrhoea	63 (.37%)
Vision Blurred	63 (.37%)
Urticaria	62 (.36%)
Sedation	61 (.35%)
Depressed Level Of Consciousness	60 (.35%)
Hypersensitivity	60 (.35%)
Tremor	60 (.35%)
Cough	59 (.34%)
Application Site Burn	57 (.33%)
Sinus Bradycardia	57 (.33%)
Cerebrovascular Accident	56 (.33%)
Gait Disturbance	54 (.31%)
Hypertensive Crisis	53 (.31%)
Drug Abuse	52 (.3%)
Erythema	52 (.3%)
Oedema Peripheral	52 (.3%)
Cardio-respiratory Arrest	51 (.3%)
Condition Aggravated	50 (.29%)
Tachycardia	50 (.29%)
Palpitations	49 (.28%)
Weight Decreased	49 (.28%)
Psychomotor Hyperactivity	47 (.27%)
Pyrexia	47 (.27%)
Dysarthria	46 (.27%)
Myocardial Infarction	45 (.26%)
Coma	44 (.26%)
Delirium	44 (.26%)
Abdominal Pain	43 (.25%)
Blood Pressure Systolic Increased	42 (.24%)
Depression	42 (.24%)
Application Site Pain	41 (.24%)
Incorrect Dose Administered	41 (.24%)
Paraesthesia	40 (.23%)
Respiratory Depression	40 (.23%)
Burning Sensation	39 (.23%)
Drug Withdrawal Syndrome	38 (.22%)
Alopecia	37 (.21%)
Intentional Drug Misuse	37 (.21%)
Renal Failure Acute	36 (.21%)
Aggression	35 (.2%)
Wrong Technique In Drug Usage Proce...	35 (.2%)
Electrocardiogram Qt Prolonged	34 (.2%)
Muscular Weakness	34 (.2%)
Sleep Disorder	34 (.2%)
Accidental Overdose	33 (.19%)
Hallucination	33 (.19%)

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This graph shows the top adverse events submitted to the FDA for Clonidine, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Clonidine is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Clonidine

What are the most common Clonidine adverse events reported to the FDA?

Administration Site Reactions	1494 (8.68%)
Neurological	1338 (7.77%)
Cardiac And Vascular Investigations	1137 (6.6%)
Therapeutic And Nontherapeutic Effe...	880 (5.11%)
Decreased And Nonspecific Blood Pre...	728 (4.23%)
Medication Errors	648 (3.76%)
Cardiac Arrhythmias	632 (3.67%)
Epidermal And Dermal Conditions	630 (3.66%)
Respiratory	522 (3.03%)
Vascular Hypertensive	501 (2.91%)
Suicidal And Self-injurious Behavio...	467 (2.71%)
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Gastrointestinal Signs	404 (2.35%)
Headaches	267 (1.55%)
Anxiety Disorders	224 (1.3%)
Infections - Pathogen Unspecified	212 (1.23%)
Chemical Injury And Poisoning	202 (1.17%)
Injuries	200 (1.16%)
Product Quality Issues	182 (1.06%)
Psychiatric	182 (1.06%)
Gastrointestinal Motility And Defec...	176 (1.02%)
Movement Disorders	176 (1.02%)
Muscle	156 (.91%)
Fatal Outcomes	147 (.85%)
Salivary Gland Conditions	140 (.81%)
Sleep Disorders	140 (.81%)
Deliria	139 (.81%)
Physical Examination Topics	133 (.77%)
Skin Appendage Conditions	131 (.76%)
Renal Disorders	127 (.74%)
Seizures	119 (.69%)
Musculoskeletal And Connective Tiss...	115 (.67%)
Procedural And Device Related Injur...	106 (.62%)
Vision	106 (.62%)
Coronary Artery	103 (.6%)
Central Nervous System Vascular	98 (.57%)
Allergic Conditions	97 (.56%)
Urinary Tract Signs	89 (.52%)
Disturbances In Thinking	87 (.51%)
Hematology Investigations	87 (.51%)
Lifestyle Issues	86 (.5%)
Electrolyte And Fluid Balance Condi...	81 (.47%)
Body Temperature Conditions	78 (.45%)
Cardiac Disorder Signs	75 (.44%)
Vascular	74 (.43%)
Metabolic, Nutritional And Blood Ga...	73 (.42%)
Depressed Mood Disorders	69 (.4%)
Angiedema And Urticaria	64 (.37%)
Mood Disorders	64 (.37%)
Renal And Urinary Tract Investigati...	62 (.36%)
Personality Disorders	53 (.31%)
Joint	52 (.3%)
Appetite And General Nutritional	50 (.29%)
Bronchial Disorders	50 (.29%)
Therapeutic Procedures And Supporti...	50 (.29%)
Lower Respiratory Tract Disorders	48 (.28%)
Ocular Neuromuscular	48 (.28%)
Neuromuscular	47 (.27%)
Eye	45 (.26%)
Hepatic And Hepatobiliary	45 (.26%)
Bacterial Infectious	43 (.25%)
Inner Ear And Viiith Cranial Nerve	41 (.24%)
Mental Impairment	41 (.24%)
Myocardial	40 (.23%)
Viral Infectious	39 (.23%)
Glucose Metabolism Disorders	38 (.22%)
Psychiatric And Behavioural Symptom...	38 (.22%)
Water, Electrolyte And Mineral	38 (.22%)
Tongue Conditions	37 (.21%)
Upper Respiratory Tract Disorders	37 (.21%)
Peripheral Neuropathies	36 (.21%)
Exocrine Pancreas Conditions	34 (.2%)
Heart Failures	33 (.19%)
Oral Soft Tissue Conditions	32 (.19%)
Changes In Physical Activity	30 (.17%)
Anemias Nonhemolytic And Marrow Dep...	27 (.16%)
Arteriosclerosis, Stenosis, Vascula...	26 (.15%)
Bone And Joint Injuries	25 (.15%)
Hepatobiliary	25 (.15%)
Miscellaneous And Site Unspecified ...	23 (.13%)
Endocrine Investigations	22 (.13%)
Platelet	21 (.12%)
Toxicology And Therapeutic Drug Mon...	21 (.12%)
Anterior Eye Structural Change, Dep...	20 (.12%)
Sleep Disturbances	20 (.12%)
Tissue	20 (.12%)
Embolism And Thrombosis	17 (.1%)
Fungal Infectious	17 (.1%)
Communication Disorders	16 (.09%)
Spinal Cord And Nerve Root	16 (.09%)
Acid-base	15 (.09%)
Dental And Gingival Conditions	15 (.09%)
Encephalopathies	15 (.09%)
Enzyme	15 (.09%)
Gastrointestinal Stenosis And Obstr...	15 (.09%)
Cognitive And Attention Disorders	14 (.08%)
Manic And Bipolar Mood Disorders	14 (.08%)
Neurological, Special Senses And Ps...	14 (.08%)
Pulmonary Vascular	14 (.08%)
Schizophrenia And Other Psychotic	14 (.08%)
Coagulopathies And Bleeding Diathes...	13 (.08%)
Vascular Hemorrhagic	13 (.08%)

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This graph shows the top categories of adverse events submitted to the FDA for Clonidine, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Clonidine is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.