CLARITHROMYCIN

Clarithromycin Adverse Events Reported to the FDA Over Time

How are Clarithromycin adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Clarithromycin, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Clarithromycin is flagged as the suspect drug causing the adverse event.

Most Common Clarithromycin Adverse Events Reported to the FDA

What are the most common Clarithromycin adverse events reported to the FDA?

Drug Interaction	1040 (4.14%)
Pyrexia	439 (1.75%)
Diarrhoea	348 (1.39%)
Dyspnoea	311 (1.24%)
Vomiting	274 (1.09%)
Renal Failure Acute	264 (1.05%)
Nausea	260 (1.04%)
Rhabdomyolysis	227 (.9%)
Rash	210 (.84%)
Confusional State	206 (.82%)
Pneumonia	188 (.75%)
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Pruritus	173 (.69%)
Hypotension	169 (.67%)
Myalgia	169 (.67%)
Asthenia	164 (.65%)
Dizziness	163 (.65%)
Malaise	162 (.65%)
Headache	161 (.64%)
Alanine Aminotransferase Increased	151 (.6%)
Blood Creatine Phosphokinase Increa...	147 (.59%)
Abdominal Pain	145 (.58%)
Erythema	143 (.57%)
Liver Function Test Abnormal	142 (.57%)
Oedema Peripheral	137 (.55%)
Dehydration	136 (.54%)
Cough	128 (.51%)
Respiratory Failure	125 (.5%)
Hepatic Function Abnormal	124 (.49%)
Liver Disorder	124 (.49%)
Pancytopenia	123 (.49%)
Dysgeusia	122 (.49%)
Stevens-johnson Syndrome	120 (.48%)
Convulsion	119 (.47%)
Tachycardia	116 (.46%)
Depressed Level Of Consciousness	115 (.46%)
Drug Toxicity	115 (.46%)
Drug Eruption	114 (.45%)
Drug Ineffective	114 (.45%)
Pleural Effusion	111 (.44%)
Aspartate Aminotransferase Increase...	106 (.42%)
Blood Creatinine Increased	105 (.42%)
Agitation	103 (.41%)
Insomnia	102 (.41%)
International Normalised Ratio Incr...	102 (.41%)
Condition Aggravated	101 (.4%)
Renal Impairment	96 (.38%)
Myositis	93 (.37%)
Agranulocytosis	91 (.36%)
Erythema Multiforme	91 (.36%)
Pseudomembranous Colitis	91 (.36%)
Thrombocytopenia	90 (.36%)
Hypoglycaemia	89 (.35%)
Sepsis	89 (.35%)
Hypersensitivity	88 (.35%)
Weight Decreased	88 (.35%)
Jaundice	86 (.34%)
Pericardial Effusion	86 (.34%)
Atrial Fibrillation	85 (.34%)
Myopathy	85 (.34%)
Urticaria	85 (.34%)
Haemoglobin Decreased	83 (.33%)
Lower Respiratory Tract Infection	83 (.33%)
Interstitial Lung Disease	82 (.33%)
Delirium	81 (.32%)
Arthralgia	80 (.32%)
Somnolence	79 (.31%)
Muscular Weakness	78 (.31%)
Decreased Appetite	75 (.3%)
Anxiety	72 (.29%)
C-reactive Protein Increased	72 (.29%)
Tubulointerstitial Nephritis	72 (.29%)
Pulmonary Embolism	71 (.28%)
Electrocardiogram Qt Prolonged	70 (.28%)
Pain	70 (.28%)
Renal Failure	70 (.28%)
Drug Hypersensitivity	69 (.27%)
Loss Of Consciousness	69 (.27%)
Abdominal Pain Upper	66 (.26%)
Anorexia	65 (.26%)
Multi-organ Failure	65 (.26%)
Anaemia	64 (.26%)
Heart Rate Increased	64 (.26%)
Hyponatraemia	64 (.26%)
Fatigue	63 (.25%)
Hyperhidrosis	63 (.25%)
Rash Maculo-papular	63 (.25%)
Swollen Tongue	63 (.25%)
Cardiac Arrest	62 (.25%)
Drug Level Increased	62 (.25%)
Torsade De Pointes	62 (.25%)
Toxic Epidermal Necrolysis	62 (.25%)
Neutropenia	60 (.24%)
Angioedema	59 (.24%)
Hallucination	59 (.24%)
Rash Generalised	59 (.24%)
Paraesthesia	58 (.23%)
Infection	56 (.22%)
Blood Alkaline Phosphatase Increase...	54 (.22%)
Bradycardia	54 (.22%)
Mouth Ulceration	54 (.22%)
Gamma-glutamyltransferase Increased	53 (.21%)

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This graph shows the top adverse events submitted to the FDA for Clarithromycin, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Clarithromycin is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Clarithromycin

What are the most common Clarithromycin adverse events reported to the FDA?

Epidermal And Dermal Conditions	1681 (6.7%)
Therapeutic And Nontherapeutic Effe...	1293 (5.15%)
Neurological	1206 (4.81%)
Respiratory	1052 (4.19%)
Gastrointestinal Signs	956 (3.81%)
Infections - Pathogen Unspecified	886 (3.53%)
Hepatic And Hepatobiliary	794 (3.16%)
Cardiac Arrhythmias	765 (3.05%)
Muscle	699 (2.79%)
Hepatobiliary	601 (2.39%)
Renal Disorders	540 (2.15%)
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Hematology Investigations	527 (2.1%)
Body Temperature Conditions	490 (1.95%)
Gastrointestinal Motility And Defec...	415 (1.65%)
Bacterial Infectious	375 (1.49%)
Cardiac And Vascular Investigations	342 (1.36%)
Electrolyte And Fluid Balance Condi...	328 (1.31%)
Deliria	319 (1.27%)
Oral Soft Tissue Conditions	287 (1.14%)
Lower Respiratory Tract Disorders	280 (1.12%)
White Blood Cell	277 (1.1%)
Anemias Nonhemolytic And Marrow Dep...	254 (1.01%)
Decreased And Nonspecific Blood Pre...	250 (1%)
Enzyme	239 (.95%)
Allergic Conditions	233 (.93%)
Anxiety Disorders	221 (.88%)
Renal And Urinary Tract Investigati...	219 (.87%)
Seizures	219 (.87%)
Chemical Injury And Poisoning	199 (.79%)
Movement Disorders	190 (.76%)
Urinary Tract Signs	190 (.76%)
Disturbances In Thinking	173 (.69%)
Medication Errors	168 (.67%)
Headaches	165 (.66%)
Physical Examination Topics	161 (.64%)
Appetite And General Nutritional	160 (.64%)
Tongue Conditions	160 (.64%)
Angiedema And Urticaria	153 (.61%)
Sleep Disorders	149 (.59%)
Nephropathies	148 (.59%)
Skin Vascular Abnormalities	146 (.58%)
Fungal Infectious	143 (.57%)
Gastrointestinal Hemorrhages	143 (.57%)
Glucose Metabolism Disorders	136 (.54%)
Platelet	134 (.53%)
Musculoskeletal And Connective Tiss...	132 (.53%)
Bronchial Disorders	129 (.51%)
Toxicology And Therapeutic Drug Mon...	128 (.51%)
Gastrointestinal Inflammatory Condi...	120 (.48%)
Pleural	120 (.48%)
Joint	115 (.46%)
Skin Appendage Conditions	114 (.45%)
Upper Respiratory Tract Disorders	111 (.44%)
Injuries	109 (.43%)
Protein And Chemistry Analyses	108 (.43%)
Viral Infectious	108 (.43%)
Ocular Infections, Irritations And ...	105 (.42%)
Vision	96 (.38%)
Pericardial	89 (.35%)
Coagulopathies And Bleeding Diathes...	87 (.35%)
Coronary Artery	87 (.35%)
Gastrointestinal Ulceration And Per...	87 (.35%)
Cardiac Disorder Signs	81 (.32%)
Pulmonary Vascular	80 (.32%)
Water, Electrolyte And Mineral	74 (.29%)
Metabolic, Nutritional And Blood Ga...	73 (.29%)
Neuromuscular	72 (.29%)
Personality Disorders	70 (.28%)
Acid-base	67 (.27%)
Manic And Bipolar Mood Disorders	67 (.27%)
Cranial Nerve Disorders	66 (.26%)
Mental Impairment	65 (.26%)
Hemolyses And Related Conditions	64 (.26%)
Inner Ear And Viiith Cranial Nerve	64 (.26%)
Suicidal And Self-injurious Behavio...	64 (.26%)
Encephalopathies	61 (.24%)
Hearing	61 (.24%)
Heart Failures	61 (.24%)
Schizophrenia And Other Psychotic	60 (.24%)
Vascular	59 (.24%)
Mycobacterial Infectious	57 (.23%)
Bile Duct	55 (.22%)
Mood Disorders	55 (.22%)
Psychiatric And Behavioural Symptom...	53 (.21%)
Purine And Pyrimidine Metabolism	53 (.21%)
Vascular Hemorrhagic	50 (.2%)
Peripheral Neuropathies	47 (.19%)
Bone, Calcium, Magnesium And Phosph...	46 (.18%)
Myocardial	46 (.18%)
Depressed Mood Disorders	44 (.18%)
Fatal Outcomes	44 (.18%)
Hematological And Lymphoid Tissue T...	44 (.18%)
Microbiology And Serology	44 (.18%)
Lifestyle Issues	43 (.17%)
Central Nervous System Vascular	40 (.16%)
Psychiatric	39 (.16%)
Eye	38 (.15%)
Salivary Gland Conditions	37 (.15%)
Ocular Neuromuscular	36 (.14%)
Fetal Complications	34 (.14%)
Spleen, Lymphatic And Reticulendoth...	34 (.14%)

Share/Embed Graph Export Data

This graph shows the top categories of adverse events submitted to the FDA for Clarithromycin, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Clarithromycin is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.