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CISPLATIN

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Cisplatin Adverse Events Reported to the FDA Over Time

How are Cisplatin adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Cisplatin, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Cisplatin is flagged as the suspect drug causing the adverse event.

Most Common Cisplatin Adverse Events Reported to the FDA

What are the most common Cisplatin adverse events reported to the FDA?

Dehydration
2223 (2.84%)
Nausea
2022 (2.58%)
Vomiting
2011 (2.57%)
Diarrhoea
1593 (2.04%)
Neutropenia
1576 (2.01%)
Febrile Neutropenia
1466 (1.87%)
Anaemia
1172 (1.5%)
Pyrexia
1130 (1.44%)
Thrombocytopenia
1051 (1.34%)
Pneumonia
978 (1.25%)
Renal Failure Acute
909 (1.16%)
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Mucosal Inflammation
874 (1.12%)
Pulmonary Embolism
873 (1.12%)
Fatigue
872 (1.11%)
Dyspnoea
794 (1.01%)
Haemoglobin Decreased
768 (.98%)
Asthenia
765 (.98%)
Sepsis
727 (.93%)
Renal Failure
707 (.9%)
White Blood Cell Count Decreased
683 (.87%)
Hyponatraemia
665 (.85%)
Dysphagia
663 (.85%)
Leukopenia
659 (.84%)
Hypotension
638 (.82%)
Hypokalaemia
632 (.81%)
Abdominal Pain
574 (.73%)
Platelet Count Decreased
562 (.72%)
Stomatitis
550 (.7%)
Blood Creatinine Increased
529 (.68%)
General Physical Health Deteriorati...
520 (.66%)
Decreased Appetite
485 (.62%)
Deep Vein Thrombosis
478 (.61%)
Death
475 (.61%)
Weight Decreased
465 (.59%)
Neutrophil Count Decreased
464 (.59%)
Malignant Neoplasm Progression
438 (.56%)
Septic Shock
424 (.54%)
Pancytopenia
404 (.52%)
Constipation
366 (.47%)
Anorexia
362 (.46%)
Hypomagnesaemia
358 (.46%)
Pain
350 (.45%)
Dizziness
341 (.44%)
Respiratory Failure
336 (.43%)
Oesophagitis
321 (.41%)
Syncope
313 (.4%)
Infection
306 (.39%)
Confusional State
299 (.38%)
Neutropenic Sepsis
294 (.38%)
Disease Progression
281 (.36%)
Hypocalcaemia
277 (.35%)
Atrial Fibrillation
274 (.35%)
Pleural Effusion
266 (.34%)
Urinary Tract Infection
263 (.34%)
Chest Pain
257 (.33%)
Convulsion
246 (.31%)
Gastrointestinal Haemorrhage
230 (.29%)
Hypertension
227 (.29%)
Malaise
227 (.29%)
Multi-organ Failure
220 (.28%)
Tachycardia
219 (.28%)
Blood Sodium Decreased
216 (.28%)
Bone Marrow Failure
212 (.27%)
Chills
202 (.26%)
Haematocrit Decreased
199 (.25%)
Rash
199 (.25%)
Cough
193 (.25%)
Fall
190 (.24%)
Headache
189 (.24%)
Drug Toxicity
188 (.24%)
Blood Potassium Decreased
185 (.24%)
Haemoptysis
181 (.23%)
Myocardial Infarction
181 (.23%)
Renal Impairment
179 (.23%)
Cardiac Arrest
178 (.23%)
Hypoxia
174 (.22%)
Lymphopenia
169 (.22%)
Hyperglycaemia
168 (.21%)
Pneumonia Aspiration
168 (.21%)
Oedema Peripheral
162 (.21%)
Pneumonitis
162 (.21%)
Electrolyte Imbalance
160 (.2%)
Cardiac Failure
157 (.2%)
Blood Urea Increased
156 (.2%)
Loss Of Consciousness
153 (.2%)
Aspartate Aminotransferase Increase...
152 (.19%)
Alanine Aminotransferase Increased
151 (.19%)
Epistaxis
150 (.19%)
Thrombosis
150 (.19%)
Hypophagia
148 (.19%)
Staphylococcal Infection
148 (.19%)
Hyperkalaemia
139 (.18%)
Blood Pressure Decreased
137 (.18%)
Colitis
135 (.17%)
Tumour Lysis Syndrome
135 (.17%)
Back Pain
134 (.17%)
Cardio-respiratory Arrest
134 (.17%)
Interstitial Lung Disease
134 (.17%)
Haemorrhage
132 (.17%)
Cerebral Infarction
131 (.17%)
Cerebrovascular Accident
130 (.17%)

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This graph shows the top adverse events submitted to the FDA for Cisplatin, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Cisplatin is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Cisplatin

What are the most common Cisplatin adverse events reported to the FDA?

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This graph shows the top categories of adverse events submitted to the FDA for Cisplatin, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Cisplatin is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Common Uses of Cisplatin According to Those Reporting Adverse Events

Why are people taking Cisplatin, according to those reporting adverse events to the FDA?

Non-small Cell Lung Cancer
3881
Gastric Cancer
1530
Head And Neck Cancer
1243
Gastrooesophageal Cancer
650
Squamous Cell Carcinoma
627
Oesophageal Carcinoma
562
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Multiple Myeloma
536
Small Cell Lung Cancer Stage Unspec...
488
Neoplasm Malignant
429
Lung Neoplasm Malignant
378
Bladder Cancer
342
Pleural Mesothelioma Malignant
317
Metastatic Gastric Cancer
312
Chemotherapy
305
Cervix Carcinoma
292
Testis Cancer
250
Bone Sarcoma
233
Germ Cell Cancer
211
Lung Adenocarcinoma
196
Oesophageal Adenocarcinoma
186
Ovarian Cancer
186
Nasopharyngeal Cancer
172
Drug Use For Unknown Indication
166
Mesothelioma
158
Transitional Cell Carcinoma
156
Non-small Cell Lung Cancer Stage Ii...
154
Non-small Cell Lung Cancer Stage Iv
154
Laryngeal Cancer
130
Breast Cancer
130
Non-hodgkins Lymphoma
118
Hepatic Neoplasm Malignant
106
Tongue Neoplasm Malignant Stage Uns...
105
Diffuse Large B-cell Lymphoma
105
Lymphoma
101
Breast Cancer Metastatic
94
Medulloblastoma
93
Oropharyngeal Cancer Stage Unspecif...
91
Pancreatic Carcinoma
91
Pharyngeal Cancer Stage Unspecified
87
Mantle Cell Lymphoma
86
Product Used For Unknown Indication
86
Oesophageal Squamous Cell Carcinoma
85
Small Cell Lung Cancer Extensive St...
85
Tonsil Cancer
84
Testicular Germ Cell Cancer
81
Hypopharyngeal Cancer
75
Endometrial Cancer
73
Anal Cancer
73
Lung Adenocarcinoma Stage Iv
73
Adenocarcinoma
72
Carcinoma
72

Drug Labels

LabelLabelerEffective
PlatinolE.R. Squibb & Sons, L.L.C.01-OCT-10
CisplatinBedford Laboratories03-NOV-10
CisplatinBedford Laboratories03-NOV-10
PlatinolCorden Pharma Latina S.p.A.13-JAN-12
Platinol-aqCorden Pharma Latina S.p.A.13-JAN-12
CisplatinPfizer Laboratories Div Pfizer Inc.21-APR-12
CisplatinTeva Parenteral Medicines, Inc.07-AUG-12
CisplatinFresenius Kabi USA, LLC04-DEC-12

Cisplatin Case Reports

What Cisplatin safety concerns are being reported by doctors and researchers in the medical literature?

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About Results

This report contains aggregated drug side effects and adverse events for Cisplatin. The data has been pulled from the United States Food and Drug Administration's (US FDA) Adverse Event Reporting System (AERS), a database containing more than 4,000,000 adverse event reports.

DrugCite expands your query using the Unified Medical Language System (UMLS) to include generic drugs and primary active ingredients. While the core of DrugCite's advanced drug filtering algorithm is based on the industry standard UMLS, DrugCite's proprietary filtering system also includes dozens of additional steps to reconcile malformed drug names in the FDA's data.

DrugCite only counts a drug if the submitter of the adverse event indicates that the drug is suspected to have caused the adverse event.

Depending on how the data is aggregated, different counts may occur. When someone submits an adverse event to the FDA, the submitter can attribute multiple adverse events to one or more drugs. For example, an individual taking Paxil could submit the adverse events "anxiety" and "suicidal ideation" for the same individual safety report (ISR). This means when DrugCite aggregates by adverse event, two distinct adverse events are counted in the adverse event graph; once for "anxiety" and again for "suicidal ideation". However, when DrugCite aggregates by individual safety reports irrespective of the details of the adverse events contained within the safety report, the report is only counted once.

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