CHLORPROMAZINE

Chlorpromazine Adverse Events Reported to the FDA Over Time

How are Chlorpromazine adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Chlorpromazine, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Chlorpromazine is flagged as the suspect drug causing the adverse event.

Most Common Chlorpromazine Adverse Events Reported to the FDA

What are the most common Chlorpromazine adverse events reported to the FDA?

Neuroleptic Malignant Syndrome	93 (1.88%)
Completed Suicide	78 (1.58%)
Somnolence	47 (.95%)
Drug Interaction	45 (.91%)
Pyrexia	45 (.91%)
Drug Toxicity	42 (.85%)
Overdose	42 (.85%)
Multiple Drug Overdose	40 (.81%)
Intentional Overdose	38 (.77%)
Drug Exposure During Pregnancy	35 (.71%)
Aggression	34 (.69%)
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Drug Ineffective	33 (.67%)
Loss Of Consciousness	31 (.63%)
Rhabdomyolysis	31 (.63%)
Death	30 (.61%)
Suicide Attempt	30 (.61%)
Tremor	30 (.61%)
Blood Creatine Phosphokinase Increa...	29 (.59%)
Cardio-respiratory Arrest	28 (.57%)
Insomnia	28 (.57%)
Coma	27 (.55%)
Depressed Level Of Consciousness	27 (.55%)
Tachycardia	25 (.51%)
Urinary Retention	25 (.51%)
Vomiting	25 (.51%)
Confusional State	24 (.49%)
Convulsion	24 (.49%)
Depression	24 (.49%)
Pneumonia	24 (.49%)
Agitation	23 (.47%)
Catatonia	23 (.47%)
Fall	23 (.47%)
Respiratory Depression	23 (.47%)
Dyspnoea	22 (.44%)
Liver Disorder	22 (.44%)
Alanine Aminotransferase Increased	21 (.42%)
Blood Pressure Decreased	21 (.42%)
Cholestasis	21 (.42%)
Pulmonary Oedema	21 (.42%)
Renal Failure Acute	21 (.42%)
Asthenia	20 (.4%)
Dyskinesia	20 (.4%)
Intestinal Obstruction	20 (.4%)
Aspartate Aminotransferase Increase...	19 (.38%)
Diarrhoea	19 (.38%)
Drug Withdrawal Syndrome Neonatal	19 (.38%)
Dystonia	19 (.38%)
Heart Rate Increased	19 (.38%)
Mental Status Changes	19 (.38%)
Muscle Rigidity	19 (.38%)
Salivary Hypersecretion	19 (.38%)
Extrapyramidal Disorder	18 (.36%)
Fatigue	18 (.36%)
Hepatitis	18 (.36%)
Psychotic Disorder	18 (.36%)
Pulmonary Embolism	18 (.36%)
Serotonin Syndrome	18 (.36%)
Blood Alkaline Phosphatase Increase...	17 (.34%)
Maternal Drugs Affecting Foetus	17 (.34%)
Suicidal Ideation	17 (.34%)
Weight Increased	17 (.34%)
Accidental Overdose	16 (.32%)
Dehydration	16 (.32%)
Dizziness	16 (.32%)
Hypotension	16 (.32%)
Pneumonia Aspiration	16 (.32%)
Cogwheel Rigidity	15 (.3%)
Hypoaesthesia	15 (.3%)
Nausea	15 (.3%)
Renal Impairment	15 (.3%)
Anxiety	14 (.28%)
Cardiac Arrest	14 (.28%)
Condition Aggravated	14 (.28%)
Decreased Appetite	14 (.28%)
Delirium	14 (.28%)
Lethargy	14 (.28%)
Metabolic Acidosis	14 (.28%)
Multiple Drug Overdose Intentional	14 (.28%)
Myocarditis	14 (.28%)
Neonatal Respiratory Distress Syndr...	14 (.28%)
Oedema Peripheral	14 (.28%)
Orthostatic Hypotension	14 (.28%)
Premature Baby	14 (.28%)
Snoring	14 (.28%)
Toxic Epidermal Necrolysis	14 (.28%)
Aspiration	13 (.26%)
Feeling Jittery	13 (.26%)
Hypokalaemia	13 (.26%)
Ileus	13 (.26%)
Medication Error	13 (.26%)
Neonatal Disorder	13 (.26%)
Speech Disorder	13 (.26%)
Blood Bilirubin Increased	12 (.24%)
Blood Glucose Increased	12 (.24%)
Cleft Palate	12 (.24%)
Hyponatraemia	12 (.24%)
Irritability	12 (.24%)
Multi-organ Failure	12 (.24%)
Psychomotor Hyperactivity	12 (.24%)
Respiratory Failure	12 (.24%)
Sedation	12 (.24%)

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This graph shows the top adverse events submitted to the FDA for Chlorpromazine, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Chlorpromazine is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Chlorpromazine

What are the most common Chlorpromazine adverse events reported to the FDA?

Neurological	314 (6.35%)
Movement Disorders	223 (4.51%)
Medication Errors	190 (3.84%)
Respiratory	157 (3.18%)
Hepatic And Hepatobiliary	156 (3.16%)
Neuromuscular	140 (2.83%)
Suicidal And Self-injurious Behavio...	140 (2.83%)
Therapeutic And Nontherapeutic Effe...	126 (2.55%)
Cardiac Arrhythmias	122 (2.47%)
Chemical Injury And Poisoning	115 (2.33%)
Epidermal And Dermal Conditions	97 (1.96%)
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Gastrointestinal Signs	95 (1.92%)
Cardiac And Vascular Investigations	88 (1.78%)
Muscle	88 (1.78%)
Infections - Pathogen Unspecified	76 (1.54%)
Hepatobiliary	72 (1.46%)
Lower Respiratory Tract Disorders	71 (1.44%)
Anxiety Disorders	63 (1.27%)
Body Temperature Conditions	59 (1.19%)
Enzyme	58 (1.17%)
Injuries	58 (1.17%)
Urinary Tract Signs	57 (1.15%)
Physical Examination Topics	55 (1.11%)
Gastrointestinal Motility And Defec...	54 (1.09%)
Disturbances In Thinking	51 (1.03%)
Seizures	51 (1.03%)
Electrolyte And Fluid Balance Condi...	50 (1.01%)
Hematology Investigations	50 (1.01%)
Fatal Outcomes	49 (.99%)
Personality Disorders	49 (.99%)
Decreased And Nonspecific Blood Pre...	47 (.95%)
Renal Disorders	45 (.91%)
Sleep Disorders	45 (.91%)
Psychiatric	44 (.89%)
Deliria	41 (.83%)
Ocular Neuromuscular	37 (.75%)
Gastrointestinal Stenosis And Obstr...	36 (.73%)
Lifestyle Issues	34 (.69%)
Musculoskeletal And Connective Tiss...	34 (.69%)
White Blood Cell	34 (.69%)
Changes In Physical Activity	33 (.67%)
Depressed Mood Disorders	33 (.67%)
Schizophrenia And Other Psychotic	33 (.67%)
Myocardial	32 (.65%)
Metabolic, Nutritional And Blood Ga...	31 (.63%)
Neonatal And Perinatal Conditions	31 (.63%)
Appetite And General Nutritional	30 (.61%)
Musculoskeletal And Connective Tiss...	30 (.61%)
Mental Impairment	27 (.55%)
Salivary Gland Conditions	26 (.53%)
Pulmonary Vascular	25 (.51%)
Bacterial Infectious	24 (.49%)
Glucose Metabolism Disorders	24 (.49%)
Toxicology And Therapeutic Drug Mon...	24 (.49%)
Neonatal Respiratory	23 (.47%)
Ocular Infections, Irritations And ...	23 (.47%)
Placental, Amniotic And Cavity Diso...	23 (.47%)
Renal And Urinary Tract Investigati...	22 (.44%)
Skin Appendage Conditions	22 (.44%)
Acid-base	20 (.4%)
Mood Disorders	20 (.4%)
Anterior Eye Structural Change, Dep...	19 (.38%)
Central Nervous System Vascular	19 (.38%)
Anemias Nonhemolytic And Marrow Dep...	18 (.36%)
Cardiac Disorder Signs	18 (.36%)
Vision	18 (.36%)
Gastrointestinal Tract Disorders Co...	17 (.34%)
Joint	17 (.34%)
Psychiatric And Behavioural Symptom...	17 (.34%)
Sexual Function And Fertility	16 (.32%)
Water, Electrolyte And Mineral	16 (.32%)
Arteriosclerosis, Stenosis, Vascula...	15 (.3%)
Manic And Bipolar Mood Disorders	15 (.3%)
Pleural	15 (.3%)
Allergic Conditions	14 (.28%)
Lipid Analyses	14 (.28%)
Heart Failures	13 (.26%)
Increased Intracranial Pressure And...	13 (.26%)
Obstetric And Gynecological Therape...	13 (.26%)
Coronary Artery	12 (.24%)
Tongue Conditions	12 (.24%)
Administration Site Reactions	11 (.22%)
Hematological And Lymphoid Tissue T...	11 (.22%)
Tissue	11 (.22%)
Microbiology And Serology	10 (.2%)
Red Blood Cell	10 (.2%)
Coagulopathies And Bleeding Diathes...	9 (.18%)
Communication Disorders	9 (.18%)
Encephalopathies	9 (.18%)
Injuries By Physical Agents	9 (.18%)
Legal Issues	9 (.18%)
Peritoneal And Retroperitoneal Cond...	9 (.18%)
Vascular Hemorrhagic	9 (.18%)
Eye	8 (.16%)
Gastrointestinal Conditions	8 (.16%)
Headaches	8 (.16%)
Neurological, Special Senses And Ps...	8 (.16%)
Oral Soft Tissue Conditions	8 (.16%)
Platelet	8 (.16%)
Therapeutic Procedures And Supporti...	8 (.16%)
Vascular	8 (.16%)

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This graph shows the top categories of adverse events submitted to the FDA for Chlorpromazine, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Chlorpromazine is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.