CAFFEINE

Caffeine Adverse Events Reported to the FDA Over Time

How are Caffeine adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Caffeine, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Caffeine is flagged as the suspect drug causing the adverse event.

Most Common Caffeine Adverse Events Reported to the FDA

What are the most common Caffeine adverse events reported to the FDA?

Completed Suicide	663 (2.59%)
Overdose	389 (1.52%)
Vomiting	383 (1.49%)
Drug Toxicity	347 (1.35%)
Drug Hypersensitivity	321 (1.25%)
Nausea	296 (1.15%)
Drug Interaction	262 (1.02%)
Somnolence	245 (.96%)
Headache	235 (.92%)
Drug Ineffective	220 (.86%)
Cardiac Arrest	216 (.84%)
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Dyspnoea	216 (.84%)
Malaise	216 (.84%)
Multiple Drug Overdose	212 (.83%)
Death	210 (.82%)
Dizziness	207 (.81%)
Respiratory Arrest	191 (.74%)
Loss Of Consciousness	183 (.71%)
Pyrexia	172 (.67%)
Abdominal Pain	165 (.64%)
Multiple Drug Overdose Intentional	161 (.63%)
Confusional State	155 (.6%)
Intentional Drug Misuse	153 (.6%)
Drug Abuse	147 (.57%)
Suicide Attempt	147 (.57%)
Constipation	146 (.57%)
Cardio-respiratory Arrest	143 (.56%)
Pain	142 (.55%)
Intentional Overdose	140 (.55%)
Back Pain	138 (.54%)
Drug Exposure During Pregnancy	133 (.52%)
Drug Dependence	132 (.51%)
Depression	131 (.51%)
Asthenia	129 (.5%)
Fatigue	129 (.5%)
Hypotension	128 (.5%)
Feeling Abnormal	125 (.49%)
Diarrhoea	123 (.48%)
Medication Error	117 (.46%)
Alanine Aminotransferase Increased	109 (.43%)
Hypertension	108 (.42%)
Hallucination	105 (.41%)
Hyperhidrosis	103 (.4%)
Pruritus	103 (.4%)
Convulsion	101 (.39%)
Poisoning	97 (.38%)
Serotonin Syndrome	97 (.38%)
Fall	94 (.37%)
Accidental Overdose	93 (.36%)
Cough	93 (.36%)
Hypersensitivity	93 (.36%)
Insomnia	93 (.36%)
Anxiety	91 (.35%)
Tachycardia	91 (.35%)
Agitation	90 (.35%)
Drug Abuser	90 (.35%)
Tremor	89 (.35%)
Respiratory Depression	88 (.34%)
Rash	87 (.34%)
Coma	85 (.33%)
Condition Aggravated	82 (.32%)
Weight Increased	82 (.32%)
Heart Rate Increased	81 (.32%)
Renal Failure	81 (.32%)
Abdominal Pain Upper	80 (.31%)
Dehydration	80 (.31%)
Depressed Level Of Consciousness	80 (.31%)
Metabolic Acidosis	78 (.3%)
Pulmonary Oedema	78 (.3%)
Aspartate Aminotransferase Increase...	75 (.29%)
Renal Failure Acute	73 (.28%)
Atrial Fibrillation	72 (.28%)
Unresponsive To Stimuli	72 (.28%)
Pneumonia	70 (.27%)
Drug Administration Error	68 (.27%)
Incorrect Dose Administered	65 (.25%)
Chest Pain	64 (.25%)
Arthralgia	63 (.25%)
Blood Pressure Increased	63 (.25%)
Lethargy	63 (.25%)
Decreased Appetite	62 (.24%)
Cerebrovascular Accident	61 (.24%)
Oedema Peripheral	60 (.23%)
Syncope	59 (.23%)
Migraine	58 (.23%)
Substance Abuse	58 (.23%)
Urticaria	58 (.23%)
Weight Decreased	58 (.23%)
Muscle Spasms	57 (.22%)
Blood Creatinine Increased	56 (.22%)
Suicidal Ideation	56 (.22%)
Pain In Extremity	55 (.21%)
Abdominal Distension	54 (.21%)
Myalgia	54 (.21%)
Hypoaesthesia	53 (.21%)
Hypokalaemia	53 (.21%)
International Normalised Ratio Incr...	53 (.21%)
Delirium	52 (.2%)
Tinnitus	52 (.2%)
Jaundice	51 (.2%)
Paraesthesia	51 (.2%)

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This graph shows the top adverse events submitted to the FDA for Caffeine, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Caffeine is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Caffeine

What are the most common Caffeine adverse events reported to the FDA?

Medication Errors	1494 (5.83%)
Neurological	1471 (5.74%)
Gastrointestinal Signs	1175 (4.58%)
Respiratory	1081 (4.22%)
Suicidal And Self-injurious Behavio...	890 (3.47%)
Chemical Injury And Poisoning	715 (2.79%)
Epidermal And Dermal Conditions	709 (2.76%)
Cardiac Arrhythmias	694 (2.71%)
Therapeutic And Nontherapeutic Effe...	674 (2.63%)
Psychiatric	632 (2.46%)
Hepatic And Hepatobiliary	542 (2.11%)
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Allergic Conditions	510 (1.99%)
Infections - Pathogen Unspecified	420 (1.64%)
Cardiac And Vascular Investigations	362 (1.41%)
Gastrointestinal Motility And Defec...	361 (1.41%)
Hepatobiliary	337 (1.31%)
Headaches	308 (1.2%)
Anxiety Disorders	305 (1.19%)
Musculoskeletal And Connective Tiss...	299 (1.17%)
Hematology Investigations	290 (1.13%)
Injuries	286 (1.12%)
Fatal Outcomes	263 (1.03%)
Renal Disorders	261 (1.02%)
Lower Respiratory Tract Disorders	258 (1.01%)
Movement Disorders	248 (.97%)
Deliria	237 (.92%)
Muscle	233 (.91%)
Physical Examination Topics	225 (.88%)
Electrolyte And Fluid Balance Condi...	214 (.83%)
Sleep Disorders	203 (.79%)
Lifestyle Issues	202 (.79%)
Decreased And Nonspecific Blood Pre...	194 (.76%)
Disturbances In Thinking	194 (.76%)
Body Temperature Conditions	185 (.72%)
Urinary Tract Signs	185 (.72%)
Appetite And General Nutritional	176 (.69%)
Depressed Mood Disorders	172 (.67%)
Gastrointestinal Hemorrhages	170 (.66%)
Metabolic, Nutritional And Blood Ga...	160 (.62%)
Seizures	158 (.62%)
Musculoskeletal And Connective Tiss...	154 (.6%)
Central Nervous System Vascular	149 (.58%)
Joint	143 (.56%)
Neuromuscular	140 (.55%)
Toxicology And Therapeutic Drug Mon...	139 (.54%)
Skin Appendage Conditions	135 (.53%)
Renal And Urinary Tract Investigati...	132 (.51%)
Acid-base	131 (.51%)
Water, Electrolyte And Mineral	130 (.51%)
Mental Impairment	120 (.47%)
Gastrointestinal Ulceration And Per...	118 (.46%)
Vision	115 (.45%)
Bronchial Disorders	114 (.44%)
Ocular Neuromuscular	111 (.43%)
Vascular Hypertensive	109 (.43%)
Mood Disorders	108 (.42%)
Vascular	108 (.42%)
Cardiac Disorder Signs	106 (.41%)
Oral Soft Tissue Conditions	103 (.4%)
Enzyme	101 (.39%)
Viral Infectious	94 (.37%)
Coronary Artery	92 (.36%)
Upper Respiratory Tract Disorders	91 (.35%)
White Blood Cell	91 (.35%)
Angiedema And Urticaria	86 (.34%)
Hearing	86 (.34%)
Exocrine Pancreas Conditions	83 (.32%)
Product Quality Issues	79 (.31%)
Procedural And Device Related Injur...	74 (.29%)
Abortions And Stillbirth	71 (.28%)
Inner Ear And Viiith Cranial Nerve	69 (.27%)
Bacterial Infectious	68 (.27%)
Bone And Joint Injuries	68 (.27%)
Gastrointestinal Inflammatory Condi...	68 (.27%)
Encephalopathies	65 (.25%)
Coagulopathies And Bleeding Diathes...	60 (.23%)
Personality Disorders	60 (.23%)
Anemias Nonhemolytic And Marrow Dep...	58 (.23%)
Therapeutic Procedures And Supporti...	55 (.21%)
Glucose Metabolism Disorders	54 (.21%)
Tongue Conditions	52 (.2%)
Gastrointestinal Conditions	51 (.2%)
Red Blood Cell	49 (.19%)
Bone Disorders	48 (.19%)
Protein And Chemistry Analyses	48 (.19%)
Schizophrenia And Other Psychotic	48 (.19%)
Changes In Physical Activity	47 (.18%)
Gastrointestinal Tract Disorders Co...	46 (.18%)
Pregnancy, Labour, Delivery And Pos...	46 (.18%)
Heart Failures	45 (.18%)
Gastrointestinal Stenosis And Obstr...	44 (.17%)
Peritoneal And Retroperitoneal Cond...	44 (.17%)
Vascular Hemorrhagic	43 (.17%)
Gastrointestinal Neoplasms Malignan...	42 (.16%)
Myocardial	42 (.16%)
Platelet	42 (.16%)
Menstrual Cycle And Uterine Bleedin...	41 (.16%)
Arteriosclerosis, Stenosis, Vascula...	40 (.16%)
Gastrointestinal Vascular Condition...	39 (.15%)
Manic And Bipolar Mood Disorders	39 (.15%)
Hematological And Lymphoid Tissue T...	38 (.15%)

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This graph shows the top categories of adverse events submitted to the FDA for Caffeine, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Caffeine is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.