ZOLEDRONOC ACID

Zoledronoc Acid Adverse Events Reported to the FDA Over Time

How are Zoledronoc Acid adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Zoledronoc Acid, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Zoledronoc Acid is flagged as the suspect drug causing the adverse event.

Most Common Zoledronoc Acid Adverse Events Reported to the FDA

What are the most common Zoledronoc Acid adverse events reported to the FDA?

Death	1734 (7.31%)
Fall	783 (3.3%)
Pain	449 (1.89%)
Malaise	443 (1.87%)
Arthralgia	397 (1.67%)
Pyrexia	378 (1.59%)
Pain In Extremity	294 (1.24%)
Bone Pain	271 (1.14%)
Back Pain	237 (1%)
Headache	230 (.97%)
Nausea	229 (.97%)
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Pneumonia	222 (.94%)
Asthenia	208 (.88%)
Myalgia	205 (.86%)
Influenza Like Illness	187 (.79%)
Chills	186 (.78%)
Hip Fracture	180 (.76%)
Gait Disturbance	178 (.75%)
Dizziness	176 (.74%)
Dyspnoea	176 (.74%)
Fatigue	175 (.74%)
Oedema Peripheral	167 (.7%)
Vomiting	162 (.68%)
Feeling Abnormal	151 (.64%)
Cerebrovascular Accident	145 (.61%)
Chest Pain	130 (.55%)
Diarrhoea	130 (.55%)
Spinal Fracture	130 (.55%)
Femur Fracture	118 (.5%)
Fracture	111 (.47%)
Wrist Fracture	111 (.47%)
Neoplasm Malignant	110 (.46%)
Rib Fracture	110 (.46%)
Drug Ineffective	108 (.46%)
Influenza	106 (.45%)
Upper Limb Fracture	99 (.42%)
Breast Cancer	98 (.41%)
Myocardial Infarction	97 (.41%)
Foot Fracture	93 (.39%)
Syncope	90 (.38%)
Joint Swelling	87 (.37%)
Hypertension	85 (.36%)
Inappropriate Schedule Of Drug Admi...	85 (.36%)
General Physical Health Deteriorati...	84 (.35%)
Musculoskeletal Pain	84 (.35%)
Pain In Jaw	82 (.35%)
Loss Of Consciousness	81 (.34%)
Erythema	80 (.34%)
Lung Neoplasm Malignant	79 (.33%)
Blood Pressure Increased	76 (.32%)
Hypokinesia	76 (.32%)
Insomnia	76 (.32%)
Urinary Tract Infection	76 (.32%)
Weight Decreased	75 (.32%)
Blood Creatinine Increased	74 (.31%)
Cough	74 (.31%)
Nasopharyngitis	73 (.31%)
Infection	72 (.3%)
Rash	72 (.3%)
C-reactive Protein Increased	69 (.29%)
Cardiac Failure	69 (.29%)
Decreased Appetite	69 (.29%)
Renal Failure	69 (.29%)
Bronchitis	68 (.29%)
Abasia	67 (.28%)
Cardiac Disorder	66 (.28%)
Lower Respiratory Tract Infection	66 (.28%)
Abdominal Pain	65 (.27%)
Chest Discomfort	64 (.27%)
Musculoskeletal Stiffness	64 (.27%)
Atrial Fibrillation	63 (.27%)
Pelvic Fracture	62 (.26%)
Tremor	62 (.26%)
Abdominal Pain Upper	61 (.26%)
Contusion	61 (.26%)
Swelling	61 (.26%)
Tooth Disorder	61 (.26%)
Bone Density Decreased	60 (.25%)
Dehydration	59 (.25%)
Renal Impairment	59 (.25%)
Muscle Spasms	57 (.24%)
Cystitis	56 (.24%)
Dementia	56 (.24%)
Creatinine Renal Clearance Decrease...	55 (.23%)
Neck Pain	55 (.23%)
Renal Failure Chronic	55 (.23%)
Glomerular Filtration Rate Decrease...	54 (.23%)
Haemoglobin Decreased	54 (.23%)
Palpitations	54 (.23%)
Sepsis	54 (.23%)
Arthritis	53 (.22%)
Osteomyelitis	53 (.22%)
Renal Disorder	53 (.22%)
Dysstasia	52 (.22%)
Inflammation	52 (.22%)
Toothache	52 (.22%)
Bone Disorder	50 (.21%)
Road Traffic Accident	50 (.21%)
Depression	49 (.21%)
Poor Venous Access	49 (.21%)
Anaemia	48 (.2%)

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This graph shows the top adverse events submitted to the FDA for Zoledronoc Acid, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Zoledronoc Acid is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Zoledronoc Acid

What are the most common Zoledronoc Acid adverse events reported to the FDA?

Fatal Outcomes	1742 (7.34%)
Bone And Joint Injuries	1663 (7.01%)
Injuries	1244 (5.24%)
Infections - Pathogen Unspecified	1136 (4.79%)
Musculoskeletal And Connective Tiss...	971 (4.09%)
Neurological	811 (3.42%)
Joint	725 (3.06%)
Gastrointestinal Signs	698 (2.94%)
Bone Disorders	602 (2.54%)
Respiratory	503 (2.12%)
Body Temperature Conditions	390 (1.64%)
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Muscle	352 (1.48%)
Epidermal And Dermal Conditions	327 (1.38%)
Renal Disorders	320 (1.35%)
Dental And Gingival Conditions	297 (1.25%)
Hematology Investigations	282 (1.19%)
Renal And Urinary Tract Investigati...	277 (1.17%)
Headaches	247 (1.04%)
Movement Disorders	237 (1%)
Cardiac And Vascular Investigations	227 (.96%)
Viral Infectious	219 (.92%)
Central Nervous System Vascular	217 (.91%)
Cardiac Arrhythmias	211 (.89%)
Gastrointestinal Motility And Defec...	183 (.77%)
Miscellaneous And Site Unspecified ...	182 (.77%)
Physical Examination Topics	161 (.68%)
Coronary Artery	160 (.67%)
Appetite And General Nutritional	156 (.66%)
Medication Errors	153 (.65%)
Cardiac Disorder Signs	149 (.63%)
Oral Soft Tissue Conditions	143 (.6%)
Vision	140 (.59%)
Therapeutic And Nontherapeutic Effe...	139 (.59%)
Vascular	131 (.55%)
Mental Impairment	124 (.52%)
Urinary Tract Signs	121 (.51%)
Heart Failures	120 (.51%)
Bacterial Infectious	117 (.49%)
Respiratory And Mediastinal Neoplas...	115 (.48%)
Eye	112 (.47%)
Breast Neoplasms Malignant And Unsp...	111 (.47%)
Tissue	110 (.46%)
Electrolyte And Fluid Balance Condi...	107 (.45%)
Bronchial Disorders	106 (.45%)
Lower Respiratory Tract Disorders	106 (.45%)
Metabolic, Nutritional And Blood Ga...	104 (.44%)
Gastrointestinal Neoplasms Malignan...	102 (.43%)
Ocular Infections, Irritations And ...	101 (.43%)
Vascular Hypertensive	100 (.42%)
Skin Appendage Conditions	94 (.4%)
Sleep Disorders	90 (.38%)
Water, Electrolyte And Mineral	88 (.37%)
Decreased And Nonspecific Blood Pre...	86 (.36%)
Protein And Chemistry Analyses	83 (.35%)
Musculoskeletal And Soft Tissue Inv...	80 (.34%)
Anxiety Disorders	78 (.33%)
Hepatic And Hepatobiliary	77 (.32%)
Musculoskeletal And Connective Tiss...	74 (.31%)
Procedural And Device Related Injur...	72 (.3%)
Gastrointestinal Hemorrhages	71 (.3%)
Administration Site Reactions	69 (.29%)
Depressed Mood Disorders	68 (.29%)
Anemias Nonhemolytic And Marrow Dep...	66 (.28%)
Fractures	64 (.27%)
Metastases	63 (.27%)
Allergic Conditions	60 (.25%)
Arteriosclerosis, Stenosis, Vascula...	58 (.24%)
Gastrointestinal Inflammatory Condi...	55 (.23%)
Tendon, Ligament And Cartilage	53 (.22%)
Gastrointestinal Ulceration And Per...	52 (.22%)
Abdominal Hernias And Other Abdomin...	51 (.22%)
Gallbladder	49 (.21%)
Glucose Metabolism Disorders	49 (.21%)
Gastrointestinal Conditions	46 (.19%)
Embolism And Thrombosis	45 (.19%)
Urolithiases	45 (.19%)
Upper Respiratory Tract Disorders	44 (.19%)
Peripheral Neuropathies	43 (.18%)
Synovial And Bursal	43 (.18%)
Deliria	42 (.18%)
Vascular Hemorrhagic	40 (.17%)
Hearing	39 (.16%)
Breast	38 (.16%)
Bone, Calcium, Magnesium And Phosph...	37 (.16%)
Cranial Nerve Disorders	37 (.16%)
Renal And Urinary Tract Neoplasms M...	37 (.16%)
Hepatobiliary	36 (.15%)
Gastrointestinal Stenosis And Obstr...	35 (.15%)
Inner Ear And Viiith Cranial Nerve	35 (.15%)
Salivary Gland Conditions	35 (.15%)
Seizures	35 (.15%)
Anterior Eye Structural Change, Dep...	34 (.14%)
Aural	34 (.14%)
Aneurysms And Artery Dissections	33 (.14%)
Pulmonary Vascular	33 (.14%)
Nephropathies	31 (.13%)
Connective Tissue Disorders	29 (.12%)
Hematological	28 (.12%)
Vascular Inflammations	27 (.11%)
Uterine, Pelvic And Broad Ligament	26 (.11%)
Skeletal Neoplasms Malignant And Un...	25 (.11%)

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This graph shows the top categories of adverse events submitted to the FDA for Zoledronoc Acid, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Zoledronoc Acid is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.