MORPHINE

Morphine Adverse Events Reported to the FDA Over Time

How are Morphine adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Morphine, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Morphine is flagged as the suspect drug causing the adverse event.

Most Common Morphine Adverse Events Reported to the FDA

What are the most common Morphine adverse events reported to the FDA?

Somnolence	1117 (1.64%)
Overdose	1017 (1.5%)
Nausea	1005 (1.48%)
Vomiting	951 (1.4%)
Drug Ineffective	935 (1.37%)
Death	848 (1.25%)
Drug Abuse	798 (1.17%)
Completed Suicide	778 (1.14%)
Confusional State	722 (1.06%)
Pain	715 (1.05%)
Respiratory Arrest	671 (.99%)
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Constipation	659 (.97%)
Cardiac Arrest	647 (.95%)
Drug Toxicity	622 (.91%)
Hypotension	621 (.91%)
Respiratory Depression	599 (.88%)
Dyspnoea	592 (.87%)
Cardio-respiratory Arrest	587 (.86%)
Loss Of Consciousness	483 (.71%)
Coma	472 (.69%)
Drug Interaction	471 (.69%)
Multiple Drug Overdose	467 (.69%)
Headache	442 (.65%)
Unresponsive To Stimuli	430 (.63%)
Drug Withdrawal Syndrome	427 (.63%)
Depressed Level Of Consciousness	425 (.62%)
Dizziness	398 (.59%)
Diarrhoea	396 (.58%)
Lethargy	392 (.58%)
Sedation	384 (.56%)
Agitation	377 (.55%)
Medication Error	376 (.55%)
Product Quality Issue	376 (.55%)
Drug Hypersensitivity	367 (.54%)
Asthenia	361 (.53%)
Fall	355 (.52%)
Abdominal Pain	346 (.51%)
Hyperhidrosis	339 (.5%)
Pyrexia	337 (.5%)
Delirium	336 (.49%)
Fatigue	323 (.47%)
Insomnia	320 (.47%)
Dehydration	316 (.46%)
Renal Failure Acute	308 (.45%)
Pruritus	304 (.45%)
Hallucination	297 (.44%)
Pneumonia	296 (.44%)
Accidental Overdose	292 (.43%)
Anxiety	291 (.43%)
Mental Status Changes	288 (.42%)
Malaise	287 (.42%)
Oxygen Saturation Decreased	276 (.41%)
Miosis	266 (.39%)
Convulsion	263 (.39%)
Respiratory Failure	254 (.37%)
Back Pain	252 (.37%)
Weight Decreased	250 (.37%)
Condition Aggravated	247 (.36%)
Oedema Peripheral	247 (.36%)
Intentional Drug Misuse	244 (.36%)
Tachycardia	242 (.36%)
Chest Pain	234 (.34%)
Disorientation	230 (.34%)
Drug Abuser	230 (.34%)
Tremor	224 (.33%)
Renal Failure	220 (.32%)
Drug Effect Decreased	217 (.32%)
Depression	214 (.31%)
Pain In Extremity	214 (.31%)
Pulmonary Oedema	210 (.31%)
Drug Dependence	209 (.31%)
Heart Rate Increased	209 (.31%)
Feeling Abnormal	205 (.3%)
Substance Abuse	203 (.3%)
Withdrawal Syndrome	193 (.28%)
Myoclonus	186 (.27%)
Decreased Appetite	184 (.27%)
Respiratory Rate Decreased	182 (.27%)
Hypertension	180 (.26%)
Drug Exposure During Pregnancy	169 (.25%)
Rash	169 (.25%)
Drug Screen Positive	166 (.24%)
Hypoaesthesia	166 (.24%)
Aggression	165 (.24%)
Rhabdomyolysis	165 (.24%)
Anaemia	161 (.24%)
Hypoxia	160 (.24%)
Pneumonia Aspiration	158 (.23%)
Aspartate Aminotransferase Increase...	154 (.23%)
General Physical Health Deteriorati...	154 (.23%)
Urinary Retention	154 (.23%)
Suicide Attempt	153 (.22%)
Abdominal Pain Upper	150 (.22%)
Post Procedural Complication	150 (.22%)
Alanine Aminotransferase Increased	149 (.22%)
Incorrect Dose Administered	149 (.22%)
Restlessness	148 (.22%)
Apnoea	147 (.22%)
Urticaria	145 (.21%)
Hyperaesthesia	144 (.21%)
Inadequate Analgesia	141 (.21%)

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This graph shows the top adverse events submitted to the FDA for Morphine, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Morphine is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Morphine

What are the most common Morphine adverse events reported to the FDA?

Neurological	6064 (8.92%)
Respiratory	3809 (5.6%)
Medication Errors	3280 (4.82%)
Gastrointestinal Signs	3160 (4.65%)
Therapeutic And Nontherapeutic Effe...	2498 (3.67%)
Cardiac Arrhythmias	2100 (3.09%)
Psychiatric	2018 (2.97%)
Deliria	1290 (1.9%)
Infections - Pathogen Unspecified	1244 (1.83%)
Gastrointestinal Motility And Defec...	1243 (1.83%)
Epidermal And Dermal Conditions	1237 (1.82%)
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Chemical Injury And Poisoning	1160 (1.71%)
Suicidal And Self-injurious Behavio...	1083 (1.59%)
Fatal Outcomes	1021 (1.5%)
Injuries	921 (1.35%)
Cardiac And Vascular Investigations	901 (1.32%)
Anxiety Disorders	870 (1.28%)
Renal Disorders	854 (1.26%)
Musculoskeletal And Connective Tiss...	784 (1.15%)
Decreased And Nonspecific Blood Pre...	774 (1.14%)
Physical Examination Topics	772 (1.14%)
Lower Respiratory Tract Disorders	730 (1.07%)
Procedural And Device Related Injur...	684 (1.01%)
Electrolyte And Fluid Balance Condi...	683 (1%)
Hematology Investigations	671 (.99%)
Movement Disorders	665 (.98%)
Metabolic, Nutritional And Blood Ga...	654 (.96%)
Muscle	652 (.96%)
Disturbances In Thinking	604 (.89%)
Hepatic And Hepatobiliary	595 (.87%)
Hepatobiliary	589 (.87%)
Allergic Conditions	585 (.86%)
Lifestyle Issues	582 (.86%)
Headaches	524 (.77%)
Product Quality Issues	511 (.75%)
Urinary Tract Signs	496 (.73%)
Sleep Disorders	464 (.68%)
Appetite And General Nutritional	461 (.68%)
Skin Appendage Conditions	456 (.67%)
Ocular Neuromuscular	443 (.65%)
Mental Impairment	438 (.64%)
Body Temperature Conditions	413 (.61%)
Seizures	390 (.57%)
Toxicology And Therapeutic Drug Mon...	368 (.54%)
Water, Electrolyte And Mineral	347 (.51%)
Coronary Artery	321 (.47%)
Renal And Urinary Tract Investigati...	317 (.47%)
Depressed Mood Disorders	308 (.45%)
Bacterial Infectious	299 (.44%)
Administration Site Reactions	298 (.44%)
Personality Disorders	290 (.43%)
Cardiac Disorder Signs	282 (.41%)
Joint	279 (.41%)
Anemias Nonhemolytic And Marrow Dep...	262 (.39%)
Enzyme	257 (.38%)
Mood Disorders	240 (.35%)
Vascular	226 (.33%)
Bone And Joint Injuries	223 (.33%)
Gastrointestinal Stenosis And Obstr...	223 (.33%)
Bronchial Disorders	214 (.31%)
Miscellaneous And Site Unspecified ...	209 (.31%)
Encephalopathies	207 (.3%)
Central Nervous System Vascular	205 (.3%)
White Blood Cell	199 (.29%)
Changes In Physical Activity	198 (.29%)
Vascular Hypertensive	187 (.27%)
Myocardial	182 (.27%)
Angiedema And Urticaria	179 (.26%)
Legal Issues	177 (.26%)
Metastases	174 (.26%)
Upper Respiratory Tract Disorders	174 (.26%)
Therapeutic Procedures And Supporti...	171 (.25%)
Vision	169 (.25%)
Neuromuscular	166 (.24%)
Acid-base	164 (.24%)
Heart Failures	164 (.24%)
Psychiatric And Behavioural Symptom...	163 (.24%)
Pulmonary Vascular	151 (.22%)
Gastrointestinal Hemorrhages	145 (.21%)
Gastrointestinal Ulceration And Per...	140 (.21%)
Arteriosclerosis, Stenosis, Vascula...	137 (.2%)
Viral Infectious	137 (.2%)
Embolism And Thrombosis	134 (.2%)
Pleural	133 (.2%)
Dental And Gingival Conditions	126 (.19%)
Increased Intracranial Pressure And...	124 (.18%)
Oral Soft Tissue Conditions	122 (.18%)
Respiratory And Mediastinal Neoplas...	116 (.17%)
Glucose Metabolism Disorders	115 (.17%)
Peritoneal And Retroperitoneal Cond...	115 (.17%)
Protein And Chemistry Analyses	112 (.16%)
Bile Duct	104 (.15%)
Bone Disorders	102 (.15%)
Sleep Disturbances	101 (.15%)
Spleen, Lymphatic And Reticulendoth...	97 (.14%)
Gastrointestinal Inflammatory Condi...	96 (.14%)
Tissue	91 (.13%)
Platelet	89 (.13%)
Gastrointestinal Conditions	88 (.13%)
Fungal Infectious	85 (.12%)
Vascular Hemorrhagic	81 (.12%)

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This graph shows the top categories of adverse events submitted to the FDA for Morphine, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Morphine is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.