CARBIDOPA AND LEVODOPA

Carbidopa And Levodopa Adverse Events Reported to the FDA Over Time

How are Carbidopa And Levodopa adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Carbidopa And Levodopa, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Carbidopa And Levodopa is flagged as the suspect drug causing the adverse event.

Most Common Carbidopa And Levodopa Adverse Events Reported to the FDA

What are the most common Carbidopa And Levodopa adverse events reported to the FDA?

Dyskinesia	102 (2.38%)
Drug Ineffective	87 (2.03%)
Tremor	73 (1.7%)
Fall	59 (1.38%)
Gait Disturbance	55 (1.28%)
Hallucination	54 (1.26%)
Nausea	54 (1.26%)
Confusional State	49 (1.14%)
Drug Effect Decreased	48 (1.12%)
Condition Aggravated	46 (1.07%)
Agitation	42 (.98%)
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Hallucination, Visual	42 (.98%)
Anxiety	39 (.91%)
On And Off Phenomenon	39 (.91%)
Vomiting	38 (.89%)
Hypersexuality	37 (.86%)
Delirium	36 (.84%)
Asthenia	33 (.77%)
Muscle Rigidity	33 (.77%)
Drug Interaction	32 (.75%)
Insomnia	32 (.75%)
Neuroleptic Malignant Syndrome	32 (.75%)
Dizziness	31 (.72%)
Pathological Gambling	31 (.72%)
Somnolence	31 (.72%)
Pneumonia	30 (.7%)
Muscle Spasms	28 (.65%)
Dopamine Dysregulation Syndrome	27 (.63%)
Fatigue	27 (.63%)
Weight Decreased	27 (.63%)
Loss Of Consciousness	26 (.61%)
Aggression	25 (.58%)
Delusion	24 (.56%)
Dysphagia	24 (.56%)
Dyspnoea	24 (.56%)
Movement Disorder	24 (.56%)
Dehydration	23 (.54%)
Bradykinesia	22 (.51%)
Hyperhidrosis	22 (.51%)
Musculoskeletal Stiffness	22 (.51%)
Pneumonia Aspiration	22 (.51%)
Constipation	21 (.49%)
Depression	20 (.47%)
Pain	20 (.47%)
Overdose	19 (.44%)
Hypotension	18 (.42%)
Oedema Peripheral	18 (.42%)
Rhabdomyolysis	18 (.42%)
Balance Disorder	17 (.4%)
Orthostatic Hypotension	17 (.4%)
Abnormal Behaviour	16 (.37%)
Disorientation	16 (.37%)
Dysarthria	16 (.37%)
Dystonia	16 (.37%)
Psychotic Disorder	16 (.37%)
Abasia	15 (.35%)
Blood Creatine Phosphokinase Increa...	15 (.35%)
Feeling Abnormal	15 (.35%)
Renal Failure Acute	15 (.35%)
Road Traffic Accident	15 (.35%)
Sudden Onset Of Sleep	15 (.35%)
Aphasia	14 (.33%)
Drug Abuse	14 (.33%)
Dysphonia	14 (.33%)
Pain In Extremity	14 (.33%)
Product Substitution Issue	14 (.33%)
Aspartate Aminotransferase Increase...	13 (.3%)
Coronary Artery Dissection	13 (.3%)
Erythema	13 (.3%)
General Physical Health Deteriorati...	13 (.3%)
Ileus Paralytic	13 (.3%)
Persecutory Delusion	13 (.3%)
Pyrexia	13 (.3%)
Abdominal Pain	12 (.28%)
Alanine Aminotransferase Increased	12 (.28%)
Completed Suicide	12 (.28%)
Diarrhoea	12 (.28%)
Impulse-control Disorder	12 (.28%)
Obsessive-compulsive Disorder	12 (.28%)
Rash	12 (.28%)
Syncope	12 (.28%)
Abdominal Discomfort	11 (.26%)
Decreased Appetite	11 (.26%)
Headache	11 (.26%)
Ileus	11 (.26%)
Incorrect Dose Administered	11 (.26%)
Irritability	11 (.26%)
Jealous Delusion	11 (.26%)
Malaise	11 (.26%)
Motor Dysfunction	11 (.26%)
Muscular Weakness	11 (.26%)
Parkinsonism	11 (.26%)
Adverse Event	10 (.23%)
Blood Urea Increased	10 (.23%)
Cerebral Atrophy	10 (.23%)
Contusion	10 (.23%)
Convulsion	10 (.23%)
Depressed Level Of Consciousness	10 (.23%)
Drug Dependence	10 (.23%)
Faecaloma	10 (.23%)
Fear	10 (.23%)

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This graph shows the top adverse events submitted to the FDA for Carbidopa And Levodopa, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Carbidopa And Levodopa is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Carbidopa And Levodopa

What are the most common Carbidopa And Levodopa adverse events reported to the FDA?

Movement Disorders	363 (8.47%)
Neurological	282 (6.58%)
Therapeutic And Nontherapeutic Effe...	225 (5.25%)
Disturbances In Thinking	181 (4.22%)
Gastrointestinal Signs	172 (4.01%)
Anxiety Disorders	114 (2.66%)
Muscle	112 (2.61%)
Injuries	111 (2.59%)
Deliria	101 (2.36%)
Respiratory	92 (2.15%)
Medication Errors	87 (2.03%)
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Musculoskeletal And Connective Tiss...	73 (1.7%)
Psychiatric	72 (1.68%)
Epidermal And Dermal Conditions	71 (1.66%)
Impulse Control	70 (1.63%)
Sleep Disorders	67 (1.56%)
Infections - Pathogen Unspecified	53 (1.24%)
Cardiac Arrhythmias	52 (1.21%)
Gastrointestinal Motility And Defec...	52 (1.21%)
Neuromuscular	52 (1.21%)
Sexual Dysfunctions, Disturbances A...	47 (1.1%)
Personality Disorders	46 (1.07%)
Hematology Investigations	44 (1.03%)
Decreased And Nonspecific Blood Pre...	39 (.91%)
Renal Disorders	39 (.91%)
Physical Examination Topics	38 (.89%)
Hepatobiliary	37 (.86%)
Hepatic And Hepatobiliary	36 (.84%)
Electrolyte And Fluid Balance Condi...	35 (.82%)
Lower Respiratory Tract Disorders	35 (.82%)
Lifestyle Issues	34 (.79%)
Mental Impairment	32 (.75%)
Depressed Mood Disorders	31 (.72%)
Mood Disorders	31 (.72%)
Cardiac And Vascular Investigations	27 (.63%)
Vision	27 (.63%)
Enzyme	26 (.61%)
Psychiatric And Behavioural Symptom...	26 (.61%)
Changes In Physical Activity	25 (.58%)
Coronary Artery	25 (.58%)
Urinary Tract Signs	24 (.56%)
Schizophrenia And Other Psychotic	23 (.54%)
Skin Appendage Conditions	23 (.54%)
Product Quality Issues	22 (.51%)
Appetite And General Nutritional	21 (.49%)
Central Nervous System Vascular	21 (.49%)
Encephalopathies	20 (.47%)
Body Temperature Conditions	19 (.44%)
Manic And Bipolar Mood Disorders	19 (.44%)
Renal And Urinary Tract Investigati...	19 (.44%)
Suicidal And Self-injurious Behavio...	19 (.44%)
Gastrointestinal Stenosis And Obstr...	17 (.4%)
Joint	17 (.4%)
Seizures	17 (.4%)
Tongue Conditions	16 (.37%)
Headaches	15 (.35%)
Sleep Disturbances	15 (.35%)
Allergic Conditions	14 (.33%)
Ocular Neuromuscular	14 (.33%)
Oral Soft Tissue Conditions	14 (.33%)
Structural Brain	14 (.33%)
Water, Electrolyte And Mineral	14 (.33%)
Bone And Joint Injuries	13 (.3%)
Vascular	13 (.3%)
Fatal Outcomes	12 (.28%)
Metabolic, Nutritional And Blood Ga...	12 (.28%)
Procedural And Device Related Injur...	12 (.28%)
Chemical Injury And Poisoning	11 (.26%)
Eye	11 (.26%)
Glucose Metabolism Disorders	11 (.26%)
Peripheral Neuropathies	9 (.21%)
Platelet	9 (.21%)
Cardiac Disorder Signs	8 (.19%)
Communication Disorders	8 (.19%)
Dental And Gingival Conditions	8 (.19%)
Gastrointestinal Inflammatory Condi...	8 (.19%)
Anemias Nonhemolytic And Marrow Dep...	7 (.16%)
Cranial Nerve Disorders	7 (.16%)
Hemolyses And Related Conditions	7 (.16%)
Ocular Structural Change, Deposit A...	7 (.16%)
Peritoneal And Retroperitoneal Cond...	7 (.16%)
Pleural	7 (.16%)
Pregnancy, Labour, Delivery And Pos...	7 (.16%)
Viral Infectious	7 (.16%)
Bacterial Infectious	6 (.14%)
Embolism And Thrombosis	6 (.14%)
Heart Failures	6 (.14%)
Neurological, Special Senses And Ps...	6 (.14%)
Protein And Chemistry Analyses	6 (.14%)
Pulmonary Vascular	6 (.14%)
Skin Neoplasms Malignant And Unspec...	6 (.14%)
Therapeutic Procedures And Supporti...	6 (.14%)
Toxicology And Therapeutic Drug Mon...	6 (.14%)
Acid-base	5 (.12%)
Bronchial Disorders	5 (.12%)
Exocrine Pancreas Conditions	5 (.12%)
Gastrointestinal Conditions	5 (.12%)
Gastrointestinal Hemorrhages	5 (.12%)
Gastrointestinal Tract Disorders Co...	5 (.12%)
Investigations, Imaging And Histopa...	5 (.12%)
Myocardial	5 (.12%)

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This graph shows the top categories of adverse events submitted to the FDA for Carbidopa And Levodopa, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Carbidopa And Levodopa is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.