Betaseron and Musculoskeletal Stiffness

This page shows results related to Betaseron and Musculoskeletal Stiffness from the FDA Adverse Event Reporting System (AERS).

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Betaseron and Musculoskeletal Stiffness

Age

40-49 Years	49
50-59 Years	44
>60 Years	41
30-39 Years	10
20-29 Years	7

Gender

Male: 15%
Female: 82%
Gender Unknown: 3%

Outcome

What were the most common outcomes of those reporting Musculoskeletal Stiffness?

Other	75
Hospitalization	45
Death	25
Disability	11

Reporter

Who most commonly reported Musculoskeletal Stiffness?

Consumer	61
Other	32
Physician	10
Pharmacist	2

Therapy

Of those reporting Musculoskeletal Stiffness, why were they taking Betaseron?

Multiple Sclerosis	50
Relapsing-remitting Multiple Sclero...	31
Drug Use For Unknown Indication	13
Secondary Progressive Multiple Scle...	12
Primary Progressive Multiple Sclero...	5

Other Medications

Which medications reported to the FDA are most commonly associated with Musculoskeletal Stiffness?

Enbrel	1728
Humira	1230
Tysabri	1123
Magnevist	951
Avonex	726
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Forteo	493
Lipitor	456
Omniscan	449
Optimark	376
Remicade	343
Vioxx	338
Lyrica	325
Multihance	323
Rebif	321
Prohance	313
Zometa	304
Crestor	280
Fosamax	278
Seroquel	271
Abilify	234
Risperdal	222
Levaquin	193
Aredia	189
Betaseron	178
Sandostatin Lar	173
Arimidex	170
Chantix	162
Reclast	155
Boniva	150
Cymbalta	137
Lioresal	136
Celebrex	135
Gilenya	130
Gadolinium In Unspecified Drug	128
Methotrexate	120
Zocor	118
Geodon	117
Paxil	116
Risperdal Consta	116
Risperidone	111
Zyprexa	104
Simvastatin	101
Oxycontin	101
Accutane	100
Neurontin	98
Zoloft	90
Lamictal	83
Niaspan	80
Digoxin	80
Byetta	79
Gleevec	77

Is the adverse drug reaction you’re experiencing actually due to the drug you took?

The Naranjo Scale is a questionnaire for determining the likelihood of whether an adverse drug reaction is actually due to the drug or caused by other factors. Probability is assigned via a score termed definite, probable, possible or doubtful.^*

	YES	NO	UNKOWN
Are there previous conclusive reports on this reaction?
Did the adverse event appear after the suspected drug was administered?
Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered?
Did the adverse reaction reappear when the drug was readministered?
Are there alternative causes (other than the drug) that could on their own have caused the reaction?
Did the reaction reappear when a placebo was given?
Was the drug detected in the blood (or other fluids) in concentrations known to be toxic?
Was the reaction more severe when the dose was increased, or less severe when the dose was decreased?
Did the patient have a similar reaction to the same or similar drugs in any previous exposure?
Was the adverse event confirmed by any objective evidence?

Probability of an Adverse Event

Doubtful

Possible

Probable

Definite

^*Naranjo, et al. "A method for estimating the probability of adverse drug reactions." Clin Pharmacol Ther. 1981 Aug;30(2):239-45.

To learn more about all adverse events for Betaseron, view the complete Betaseron adverse event report.

Scientific Publications on Musculoskeletal Stiffness

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