Avandia and Macular Oedema

This page shows results related to Avandia and Macular Oedema from the FDA Adverse Event Reporting System (AERS).

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Avandia and Macular Oedema

Age

>60 Years	129
50-59 Years	101
40-49 Years	38
30-39 Years	6
20-29 Years	1

Gender

Male: 60%
Female: 36%
Gender Unknown: 4%

Outcome

What were the most common outcomes of those reporting Macular Oedema?

Other	201
Hospitalization	170
Disability	31
Death	29
Required Intervention	14
Life Threatening	2

Reporter

Who most commonly reported Macular Oedema?

Consumer	255
Physician	72
Lawyer	31
Other	23
Pharmacist	22

Therapy

Of those reporting Macular Oedema, why were they taking Avandia?

Diabetes Mellitus	118
Type 2 Diabetes Mellitus	38
Drug Use For Unknown Indication	33
Prophylaxis	2
Glucose Tolerance Impaired	2

Other Medications

Which medications reported to the FDA are most commonly associated with Macular Oedema?

Avandia	402
Gilenya	206
Actos	112
Vioxx	71
Avandamet	69
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Xalatan	62
Fosamax	55
Lucentis	48
Avastin	42
Visudyne	38
Taxol	36
Miochol-e	35
Prednisolone	33
Lantus	31
Viagra	31
Enbrel	30
Abraxane	30
Remicade	30
Humalog	27
Lyrica	25
Gleevec	19
Metformin Hcl	19
Neoral	18
Pegasys	16
Cialis	15
Pregabalin	14
Taxotere	13
Paclitaxel	13
Topiramate	13
Revlimid	13
Phenytoin	12
Rosiglitazone	12
Perindopril Erbumine	12
Ranibizumab	12
Humulin R	12
Bevacizumab	11
Pioglitazone Hcl	11
Exenatide	11
Cyclosporine	11
Humulin N	11
Rovalcyte	10
Januvia	10
Amaryl	10
Flomax	10
Avandaryl	9
Travatan Z	9
Niaspan	9
Rituximab	9
Macugen	9
Byetta	8
Iressa	8

Is the adverse drug reaction you’re experiencing actually due to the drug you took?

The Naranjo Scale is a questionnaire for determining the likelihood of whether an adverse drug reaction is actually due to the drug or caused by other factors. Probability is assigned via a score termed definite, probable, possible or doubtful.^*

	YES	NO	UNKOWN
Are there previous conclusive reports on this reaction?
Did the adverse event appear after the suspected drug was administered?
Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered?
Did the adverse reaction reappear when the drug was readministered?
Are there alternative causes (other than the drug) that could on their own have caused the reaction?
Did the reaction reappear when a placebo was given?
Was the drug detected in the blood (or other fluids) in concentrations known to be toxic?
Was the reaction more severe when the dose was increased, or less severe when the dose was decreased?
Did the patient have a similar reaction to the same or similar drugs in any previous exposure?
Was the adverse event confirmed by any objective evidence?

Probability of an Adverse Event

Doubtful

Possible

Probable

Definite

^*Naranjo, et al. "A method for estimating the probability of adverse drug reactions." Clin Pharmacol Ther. 1981 Aug;30(2):239-45.

To learn more about all adverse events for Avandia, view the complete Avandia adverse event report.

Scientific Publications on Macular Oedema

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