Ambrisentan and Fluid Retention

This page shows results related to Ambrisentan and Fluid Retention from the FDA Adverse Event Reporting System (AERS).

Adverse Event

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Ambrisentan and Fluid Retention

Age

>60 Years	18
50-59 Years	4
30-39 Years	2
40-49 Years	1

Gender

Male: 43%
Female: 57%

Outcome

What were the most common outcomes of those reporting Fluid Retention?

Hospitalization	15
Other	8
Death	1
Life Threatening	1

Reporter

Who most commonly reported Fluid Retention?

Physician	17
Other	4
Consumer	1
Pharmacist	1

Therapy

Of those reporting Fluid Retention, why were they taking Ambrisentan?

Pulmonary Arterial Hypertension	19
Pulmonary Hypertension	4
Scleroderma	1

Other Medications

Which medications reported to the FDA are most commonly associated with Fluid Retention?

Avandia	899
Tracleer	525
Vioxx	467
Gleevec	462
Letairis	419
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Lyrica	369
Fosamax	354
Avonex	279
Forteo	234
Humira	232
Zometa	198
Dianeal	175
Alli	166
Byetta	161
Actos	153
Enbrel	153
Celebrex	138
Chantix	131
Avandamet	128
Tysabri	124
Revlimid	124
Neurontin	119
Digoxin	118
Sandostatin Lar	112
Aredia	106
Remicade	105
Exjade	93
Diovan	85
Lipitor	85
Tasigna	85
Rebif	82
Humalog	78
Lantus	76
Furosemide	75
Ventavis	75
Mirena	74
Tyvaso	73
Zyprexa	69
Extraneal	68
Sutent	66
Cymbalta	65
Humulin N	61
Crestor	61
Sprycel	60
Spiriva	60
Bextra	58
Nexavar	58
Duragesic-100	57
Pradaxa	56
Coreg	56
Seroquel	55

Is the adverse drug reaction you’re experiencing actually due to the drug you took?

The Naranjo Scale is a questionnaire for determining the likelihood of whether an adverse drug reaction is actually due to the drug or caused by other factors. Probability is assigned via a score termed definite, probable, possible or doubtful.^*

	YES	NO	UNKOWN
Are there previous conclusive reports on this reaction?
Did the adverse event appear after the suspected drug was administered?
Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered?
Did the adverse reaction reappear when the drug was readministered?
Are there alternative causes (other than the drug) that could on their own have caused the reaction?
Did the reaction reappear when a placebo was given?
Was the drug detected in the blood (or other fluids) in concentrations known to be toxic?
Was the reaction more severe when the dose was increased, or less severe when the dose was decreased?
Did the patient have a similar reaction to the same or similar drugs in any previous exposure?
Was the adverse event confirmed by any objective evidence?

Probability of an Adverse Event

Doubtful

Possible

Probable

Definite

^*Naranjo, et al. "A method for estimating the probability of adverse drug reactions." Clin Pharmacol Ther. 1981 Aug;30(2):239-45.

To learn more about all adverse events for Ambrisentan, view the complete Ambrisentan adverse event report.

Scientific Publications on Fluid Retention

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