Ambisome and Cardiac Failure

This page shows results related to Ambisome and Cardiac Failure from the FDA Adverse Event Reporting System (AERS).

Adverse Event

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Ambisome and Cardiac Failure

Age

>60 Years	15
1-9 Years	3
50-59 Years	3
0-12 Months	2
20-29 Years	2
40-49 Years	2
10-19 Years	1

Gender

Male: 64%
Female: 36%

Outcome

What were the most common outcomes of those reporting Cardiac Failure?

Death	14
Other	14
Hospitalization	9
Life Threatening	7

Reporter

Who most commonly reported Cardiac Failure?

Other	14
Physician	10
Pharmacist	2

Therapy

Of those reporting Cardiac Failure, why were they taking Ambisome?

Bronchopulmonary Aspergillosis	10
Fungal Infection	7
Pulmonary Mycosis	2
Laryngitis Bacterial	2
Meningitis Cryptococcal	2

Other Medications

Which medications reported to the FDA are most commonly associated with Cardiac Failure?

Vioxx	2147
Dianeal	1519
Avandia	992
Humira	597
Tracleer	502
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Digoxin	477
Revlimid	445
Remicade	384
Forteo	367
Diovan	317
Lyrica	309
Cyclophosphamide	309
Enbrel	295
Velcade	291
Celebrex	272
Zometa	242
Multaq	241
Fosamax	240
Gleevec	239
Extraneal	235
Aliskiren	231
Heparin Sodium Injection	228
Methotrexate	221
Aspirin	220
Enalapril Maleate	219
Actos	216
Lasix	215
Doxorubicin Hcl	213
Prednisolone	212
Dronedarone Hcl	207
Avandamet	205
Letairis	201
Avonex	197
Fluorouracil	193
Pradaxa	193
Paxil	188
Exjade	185
Furosemide	180
Cyclosporine	175
Sutent	169
Plavix	168
Cisplatin	162
Avastin	161
Lipitor	157
Micardis	155
Bextra	151
Risperdal	148
Spiriva	147
Cytarabine	145
Dexamethasone	143
Herceptin	139

Is the adverse drug reaction you’re experiencing actually due to the drug you took?

The Naranjo Scale is a questionnaire for determining the likelihood of whether an adverse drug reaction is actually due to the drug or caused by other factors. Probability is assigned via a score termed definite, probable, possible or doubtful.^*

	YES	NO	UNKOWN
Are there previous conclusive reports on this reaction?
Did the adverse event appear after the suspected drug was administered?
Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered?
Did the adverse reaction reappear when the drug was readministered?
Are there alternative causes (other than the drug) that could on their own have caused the reaction?
Did the reaction reappear when a placebo was given?
Was the drug detected in the blood (or other fluids) in concentrations known to be toxic?
Was the reaction more severe when the dose was increased, or less severe when the dose was decreased?
Did the patient have a similar reaction to the same or similar drugs in any previous exposure?
Was the adverse event confirmed by any objective evidence?

Probability of an Adverse Event

Doubtful

Possible

Probable

Definite

^*Naranjo, et al. "A method for estimating the probability of adverse drug reactions." Clin Pharmacol Ther. 1981 Aug;30(2):239-45.

To learn more about all adverse events for Ambisome, view the complete Ambisome adverse event report.

Scientific Publications on Cardiac Failure

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